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Major achievements

Excellent skills in the field of the synthesis of heterocyclic compounds, strong in use of the mixture of reagents and expertise in hand on the synthesis of benzonitrile, phenol, naphthol, coumarin, thiocoumarin, quinoline, quinozoline, pyrimidine, pyridine, indole, indazole, Imidazole and benzimidazole annulated heterocycles.
Creativity in problem solving: Development of new synthetic routes /methodology in the synthesis of heterocyclic compounds.

 

Education

• 2006.9-2011.1 Ph.D. at Fudan University (China) with Prof. (Dr.) Fener Chen. Specialization in Organic Chemistry.
  “Research of Non-nucleoside HIV Reverse Transcriptase Inhibitors I: Design, Synthesis and SAR Research of the Hybrid DABP Analogues II: Optimization, Synthesis and SAR Research of the CH2-DAPY Analogues”
• 9-2006.6 Master of Science in Chemistry at Xuzhou Normal University (China)
  Specialization in Organic Chemistry. Research project under the supervision of Prof. Xiangshan Wang.
  “Studies on the Applications of KF-Al2O3 in Organic Synthesis”

Laboratory Skills

• Manipulation of air sensitive materials using standard Schlenk, high vacuum and glove box techniques.
• Synthesis and characterization of organic and organometallic compounds using common bench techniques (Multi-step synthesis, purification and analytical techniques, HPLC, GC).
• Synthesis of catalysts (1st and 2nd generation Grubbs) and sensitive intermediates (carbeneligands).
• Capable of analysing and proposing multistep syntheses of natural products based on
  Disconnection approach.
• Competent in a number of software packages (e.g. EndNote, Word, Excel, Power Point) and various chemistry related software and databases (e.g. ChemDraw, Isis, SciFinder, Beilstein MDL CrossFire)

Publications

1. Zhao-Sen Zeng, Yong-Hong Liang, Xiao-Qing Feng, Fen-Er Chen, Christophe Pannecouque, Jan Balzarini, Erik De Clercq, Lead Optimization of Diarylpyrimidines as Inhibitors of Non-nucleoside HIV-1 Reverse Transcriptase, ChemMedChem 2010 , 5, 837-840.

2. Zhao-Sen Zeng, Qiu-Qin He, Yong-Hong Liang, Xiao-Qing Feng, Fen-Er Chen, Erik De Clercq, Jan Balzarini, Christophe Pannecouque, Hybrid Diarylbenzopyrimidine Non-Nucleoside Reverse Transcriptase Inhibitors as Promising New Leads for Improved Anti-HIV-1 Chemotherapy, Bioorg. Med. Chem. 2010, 18, 5039-5047.

3. Xiao-Qing Feng, Yong-Hong Liang, Zhao-Sen Zeng, Fen-Er Chen, Jan Balzarini, Christophe Pannecouque, Erik De Clercq, Structural Modifications of DAPY Analogues with Potent Anti-HIV-1 Activity, ChemMedChem 2009, 4 , 219-224.

4. Yong-Hong Liang, Xiao-Qing Feng, Zhao-Sen Zeng, Fen-Er Chen, Jan Balzarini, Christophe Pannecouque, Erik De Clercq, Design, Synthesis, and SAR of Naphthyl-Substituted Diarylpyrimidines as Non-Nucleoside Inhibitors of HIV -1 Reverse Transcriptase, ChemMedChem 2009, 4, 1537-1545.

5. Xiao-Qing Feng, Zhao-Sen Zeng, Yong-Hong Liang, Fen-Er Chen, Christophe Pannecouque, Jan Balzarini, Erik De Clercq, Synthesis and Biological Evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as Potential Non-nucleoside Reverse Transcriptase Inhibitors against HIV. Bioorg. Med. Chem. 2010, 18, 2370-2374

6. Xiang-Shan Wang, Zhao-Sen Zeng, Da-Qing Shi, Xian-Yong Wei and Zhi-Min Zong. One-step synthesis of 2-amino-3-cyano-4-aryl-1,4,5, 6-tetrahydropyrano[3,2-c]quinolin- 5-one derivatives using KF-Al2O3 as catalyst[J]. Synth. Commun., 2004, 34(16): 3021~3027.

7. Xiang-Shan Wang, Zhao-Sen Zeng, Da-Qing Shi, Xian-Yong Wei and Zhi-Min Zong. A readily synthesis of 2-amino-3-cyano-4-aryl-1,4,5,6 -tetrahydrobenzo[h]chromenes derivatives using KF-Al2O3 as catalyst[J]. Synth. Commun., 2004, 34(18): 3265~3271.

8. Xiang-Shan Wang, Zhao-Sen Zeng, Da-Qing Shi, Xian-Yong Wei and Zhi-Min Zong. KF-alumina catalyzed one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives[J]. Synth. Commun., 2004, 34(23), 4331~4338.

9. Xiang-Shan Wang, Zhao-Sen Zeng, Da-Qing Shi, Shu-Jiang Tu, Xian-Yong Wei and Zhi-Min Zong. Three-component, one-pot synthesis of pyrido[2,3-d]pyrimidine Derivatives catalyzed by KF-alumina[J]. Synth. Commun., 2005, 35: 1921~1927.

10. Xiang-Shan Wang, Zhao-Sen Zeng, Yu-Ling Li, Da-Qing Shi, Xian-Yong Wei and Zhi-Min Zong. Simple procedure for the synthesis of arylmethylenemalononitrile without catalyst[J]. Synth. Commun., 2005, 35: 1915~1920.

11. Xiang-Shan Wang, Zhao-Sen Zeng, Da-Qing Shi, Xian-Yong Wei and Zhi-Min Zong The structure of 2-amino-3-cyano-4-(4-methylphenyl)-6-methoxyl-1 ,4,9,10-tetrahydrobenzo[f]chromene[J]. J. Chem. Cryst. 2005, 35(3): 243~247.

12. Xiang-Shan Wang, Zhao-Sen Zeng, Da-Qing Shi, Xian-Yong Wei, Zhi-Min Zong. The crystal structure and unclassical pyran conformation of 2-amino-7-methyl-4- (3-nitrophenyl) -5-oxo-4H,5H-pyran[4,3-b]pyran-3-carbonirrile[J]. J. Chem. Res. (S), 2005, 12: 775~777.