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Major achievements

Research Experience

• Sep. 2006-present         Working towards Ph.D (Organic Chemistry)
  Projects
  1. A theoretical study of the interaction between dapivirine (TMC120) and HIV-1 reverse transcriptase
  2. Quantitative structure-activity relationship study of benzyl substituted diarylpyrimidines
  3. Design, synthesis and SAR studies of α or β naphthyl substituted diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
  4. Design and synthesis of DABOs as dual inhibitors of HIV-1 reverse transcriptase and integrase

 

• 2003-2006                    Master Candidate
  Projects
  1. The ground- and excited-state intramolecular proton transfer for 2-hydroxybenzophenone, 8-hydroxy-4H-naphthalen-1-one, 5-hydroxy-4, 5-naphthoquinone, 1-hydroxy-9, 10-anthraquione, 7- Hydroxy-1-indenone, 5, 8-dihydroxy-1, 4-naphthoquinone), 4, 9-dihydroxyperylene-3, 10-quinone and hypocrellin A was studied by theoretical methods.
  2. The ground-state inermolecular proton transfer in the complexes of 5-hydroxyisoxazole-water, DNA (RNA) base dimer and base-N-methylformamide was performed by DFT methods.
  2002-2003 Quantitative structure-property relationship on the physicochemical property of ketone and aldehyde

Awards

Hunan Province excellence Master Thesis, 2008

Publications

1. Liang, Y. H.; Chen, F. E. ONIOM DFT/PM3 calculations on the interaction betweenndapivirine and HIV-1 reverse transcriptase, a theoretical study. Drug Discov. Ther. 2007, 1, 57-60.

2. Liang, Y. H.; Chen, F. E. QSAR studies for diarylpyrimidines against HIV-1 reverse transcriptase wild-type and mutant strains. Eur. J. Med. Chem. 2009, 44, 625-631

3. Liang, YH; Feng, XQ; Zeng, ZS; Chen, FE; Balzarini, J.; Pannecouque, C.; De Clercq, E. Design, Synthesis, and SAR of Naphthyl-Substituted Diarylpyrimidines as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. ChemMedChem 2009, 4, 1537-1545.

4. Feng, XQ; Liang, YH; Zeng, ZS; Chen, FE; Balzarini, J.; Pannecouque, C.; De Clercq, E. Structural Modifications of DAPY Analogues with Potent Anti-HIV-1 Activity. ChemMedChem 2009, 4, 219.

5. Zeng, ZS; Liang, YH; Feng, XQ; Chen, FE; Balzarini, J.; Pannecouque, C.; De Clercq, E. Lead optimization of diarylpyrimidines as inhibitors of non-nucleoside HIV-1 reverse transcriptase, ChemMedChem 2010, accepted.

6. Liang, Y. H.; Yi, P. G. Theoretical studies on structure, energetic and intramolecular proton transfer of alkannin. Chemical Physics Lettters, 2007, 438, 173.

7. Liang, Y. H.; Yi, P. G.; Peng, H. L. Theoretical study of structure, energetic and intramolecular hydrogen transfer of hypocrellin A. Chemical Physics Lettters, 2008, 466, 6-10.

8. Liang, Y. H.; Yi, P. G.. Cao, C. Z. A theoretical study on the solvent-assisted proton transfer in 5-hydroxyisoxazole. Journal of Molecular Structure: Theochem, 2005, 729, 163–167.

9. Yi, P. G..; Liang, Y. H.; Cao, C. Z. Intramolecular proton or hydrogen-atom transfer in the ground and excited states of 2-hydroxybenzophenone: A theoretical Study. Chemical Physics, 2005, 319, 297.

10. Yi, P. G..; Liang, Y. H. Theoretical studies of conjugation and subsidiary effects on intramolecular proton transfer in the ground and excited states. Chemical Physics, 2006, 322, 382.

11. Yi, P. G..; Liang, Y. H. Tang, Z. Q. Theoretical study of intermolecular proton transfer reaction in isolated 5-hydroxyisoxazole–water complexes. Chemical Physics, 2006, 2006, 322, 387.

12. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J.; Pannecouque, C.; De Clercq, E. Parallel Synthesis and Biological Evaluation of Diarylpyrimidines with Potent Anti-HIV-1 Activity. Med. Chem. 2010, 18(13), 4601.

13. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J.; Pannecouque, C.; De Clercq, E. Design of DABOs as dual inhibitors of HIV-1 reverse transcriptase and integrase. J. Med. Chem.

14. Chen, F. E., Liang, Y. H. Recent Progress on the Multi-target Anti-AIDS Drugs, Progess in Medical Chemistry (8), Peng, S. Q. Ed., 2011, 167.

15. Chen, F. E., Liang, Y. H., Zeng, Z. S. PCT/CN2009/075931.

16. Zeng, Z. S., Liang, Y. H., Zhang, J. Y., Xiong, J. C. China Patent,, CN201110070027.4