Description

Tetrahydro-4H-pyran-4-one(29943-42-8) is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes. The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. It is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. It is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3

Novel amphiphilic poly(2-oxazoline)s bearing L-prolinamide moieties at the alkyl side-chain termini were designed and synthesized by a bottom-up protocol. These polymers formed micelle-type assemblies with a size of 10–30 nm in water, in which the majority of prolinamide active groups was tucked into the hydrophobic inner core. As a nanoreactor, the micellar systems were successfully applied to the direct asymmetric aldol reaction in aqueous media. The results demonstrated that the polymer-bound prolinamide catalysts show a significant improvement in catalytic efficiency when compared with their monomeric counterpart and non-amphiphilic reference polymer, affording the anti-product with a moderate stereoselectivity in the representative aldol addition of cyclohexanone to p-nitrobenzaldehyde. Additionally, the poly(2-oxazoline) derivatives can also promote effectively the reactions of Tetrahydro-4H-pyran-4-one(29943-42-8) or cyclopentanone donors to give the corresponding aldol adducts in high yield and with good diastereo- and enantioselectivities.

Tetrahydro-4H-pyran-4-one(29943-42-8) Specifications

CAS	29943-42-8
CAS Min %	95%
CAS Max %	100%
MDL Number	MFCD08272232
InChI Key	JMJRYTGVHCAYCT-UHFFFAOYSA-N
Chemical Name or Material	Tetrahydro-4H-pyran-4-one
Infrared Spectrum	Authentic
Physical Form	Liquid
Packaging	Glass bottle
Molecular Formula	C5H8O2
Molecular Weight (g/mol)	100.117
SMILES	C1COCCC1=O
Color	Colorless through Yellow
Melting Point	165° to 167°C
Assay	98%

Tetrahydro-4H-pyran-4-one(29943-42-8)Safety and Handling

(29943-42-8)GHS H Statement

• H227
• Combustible liquid.

(29943-42-8)GHS P Statement

• P210-P280-P370+P378a-P403+P235-P501a
• Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
• Wear protective gloves/protective clothing/eye protection/face protection.
• In case of fire: Use for extinction: CO2, powder or water spray.
• Store in a well-ventilated place. Keep cool.
• Dispose of contents/container in accordance with local/regional/national/international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Tetrahydro-4H-pyran-4-one(29943-42-8)Articles 

Novel amphiphilic poly(2-oxazoline)s bearing L-prolinamide moieties as the pendants: Synthesis, micellization and catalytic activity in aqueous aldol reaction

Novel amphiphilic poly(2-oxazoline)s bearing L-prolinamide moieties at the alkyl side-chain termini were designed and synthesized by a bottom-up protocol.

Polymer (United Kingdom) 2016

Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile

Novel antibacterial drugs that are effective against infections caused by multidrug resistant pathogens are urgently needed.

Journal of Medicinal Chemistry 2015

Tetrahydro-4H-pyran-4-one(29943-42-8)Technical Service:

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