Tetrahydro-4H-pyran-4-one (29943-42-8)

(2 customer reviews)

This product(s) resides on a APICMO contract.

We have the ability to produce, synthesize and manufacture large quantities of  Tetrahydro-4H-pyran-4-one(29943-42-8) with quality control system under CGMP manufacturing regulations.



Tetrahydro-4H-pyran-4-one(29943-42-8) video


Tetrahydro-4H-pyran-4-one(29943-42-8) is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes. The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. It is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. It is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3

Novel amphiphilic poly(2-oxazoline)s bearing L-prolinamide moieties at the alkyl side-chain termini were designed and synthesized by a bottom-up protocol. These polymers formed micelle-type assemblies with a size of 10–30 nm in water, in which the majority of prolinamide active groups was tucked into the hydrophobic inner core. As a nanoreactor, the micellar systems were successfully applied to the direct asymmetric aldol reaction in aqueous media. The results demonstrated that the polymer-bound prolinamide catalysts show a significant improvement in catalytic efficiency when compared with their monomeric counterpart and non-amphiphilic reference polymer, affording the anti-product with a moderate stereoselectivity in the representative aldol addition of cyclohexanone to p-nitrobenzaldehyde. Additionally, the poly(2-oxazoline) derivatives can also promote effectively the reactions of Tetrahydro-4H-pyran-4-one(29943-42-8) or cyclopentanone donors to give the corresponding aldol adducts in high yield and with good diastereo- and enantioselectivities.

Tetrahydro-4H-pyran-4-one(29943-42-8) Specifications

CAS 29943-42-8
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD08272232
Chemical Name or Material Tetrahydro-4H-pyran-4-one
Infrared Spectrum Authentic
Physical Form Liquid
Packaging Glass bottle
Molecular Formula C5H8O2
Molecular Weight (g/mol) 100.117
Color Colorless through Yellow
Melting Point 165° to 167°C
Assay 98%

Tetrahydro-4H-pyran-4-one(29943-42-8)Safety and HandlingAPICMO hazard icons

(29943-42-8)GHS H Statement

  • H227
  • Combustible liquid.

(29943-42-8)GHS P Statement

  • P210-P280-P370+P378a-P403+P235-P501a
  • Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
  • Wear protective gloves/protective clothing/eye protection/face protection.
  • In case of fire: Use for extinction: CO2, powder or water spray.
  • Store in a well-ventilated place. Keep cool.
  • Dispose of contents/container in accordance with local/regional/national/international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.


Novel amphiphilic poly(2-oxazoline)s bearing L-prolinamide moieties as the pendants: Synthesis, micellization and catalytic activity in aqueous aldol reaction

Novel amphiphilic poly(2-oxazoline)s bearing L-prolinamide moieties at the alkyl side-chain termini were designed and synthesized by a bottom-up protocol.

Polymer (United Kingdom) 2016

Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile

Novel antibacterial drugs that are effective against infections caused by multidrug resistant pathogens are urgently needed.

Journal of Medicinal Chemistry 2015

Tetrahydro-4H-pyran-4-one(29943-42-8)Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Tetrahydro-4H-pyran-4-one(29943-42-8)Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?


2 reviews for Tetrahydro-4H-pyran-4-one (29943-42-8)


    Tetrahydro-4H-pyran-4-one(29943-42-8) In-Depth Introduction

    At Apicmo, we synthesize and produce large quantities of tetrahydro-4h-pyran-4-one, among other chemicals. Our products meet the requirements of the CGMP manufacturing regulations basing on the quality control system. 29943-42-8 falls in the same category as heterocycles.

    Tetrahydro-4H-Pyran-4-one (29943-42-8) Description

    The primary applications of Tetrahydro-4H-Pyran-4-one (29943-42-8) are preparing the 4-methoxytetrahydropyran-4-yl protecting agent and synthesizing of symmetric tetra-substituted methane.

    Methyl enol ether is applicable in the following areas:

    • It is an alcohol-protecting agent
    • The element is useful for research and the study of enantioselective alpha-aminoxylation of ketones.
    • Preparations of spiroimidazoles and dipeptides upon condensation
    • Synthesizing penicillin in Wittig reactions

    We designed novel amphiphilic poly(2-oxazoline)bearing theL-prolinamide moieties within the alkyl side chain. When subjected under water, the polymers form micelle-type associations, ranging between 10-30 nm. Most of the prolinamide active groups are located within the hydrophobic inner core. We then applied the micellar systems to the direct asymmetric aldol reaction in an aqueous media.

    From the results, we found out that polymer-bound prolinamide catalysts have improved efficiency in comparison to the non-amphiphilic polymer or their monomeric counterpart. The derivatives of poly(2-oxazoline) enhance the reaction of Tetrahydro-4H-Pyran-4-one giving a corresponding aldol adduct. The yield is typically higher with good enantioselectivities.

    Chemical structure of Tetrahydro-4H-Pyran-4-one (29943-42-8)

    (CAS 29943-42-8) Tetrahydro-4H-pyran-4-one

    Tetrahydro-4H-Pyran-4-one (29943-42-8) Product Specifications

    CAS no. 29943-42-8
    Chemical name Tetrahydro-4H-pyran-4-one
    Density (g/cm3) 1.065
    IUPAC name Oxan-
    Flash point (°C) 55 – 63
    Boiling point (˚C) 165 – 167
    Molecular formula C5H8O2
    Molecular weight (g/mol) 100.117
    Monoisotopic mass (g/mol) 100.052
    Physical state Liquid
    Purity 98%
    Structural formula (CAS 29943-42-8) Tetrahydro-4H-pyran-4-one
    Synonyms · Tetrahydro-4-pyranone

    · 4H-Pyran-4-one, tetrahydro-

    · Oxan-4-one

    · 4-Oxotetrahydropyran

    · 4-Oxacyclohexanone

    · Tetrahydropyran-4-one

    · Trihydro-2H-pyran-4-one

    Tetrahydro-4H-Pyran-4-one (29943-42-8) Chemical and Physical Properties

    The solubility of Tetrahydro-4H-Pyran-4-one (29943-42-8)

    The product is highly soluble with water

    29943-42-8 bonding

    Hydrogen bond Donor count –none

    Acceptor count –2 units

    Rotatable bond None
    Covalent 1

    Tetrahydro-4H-Pyran-4-one appearance

    It is a colorless liquid

    Tetrahydro-4H-Pyran-4-one (29943-42-8) Computed Properties

    Property Name Property value
    XLogP3-AA -0.50
    Vapor pressure (mmHg) 1.69 at 25°C
    Undefined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    PSA 26.3 A^2
    Refractive index 1.451
    Isotope Atom Count 0
    Heavy Atom Count 7
    Formal Charge 0
    Exact Mass (g/mol) 100.052
    Defined Bond Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Compound is Canonicalized Yes
    Complexity 70.1

    Tetrahydro-4H-Pyran-4-one (29943-42-8) Synthesis Route

    The product has up to 14 synthesis routes though we shall consider the best five methods.

    (CAS 29943-42-8) Tetrahydro-4H-pyran-4-one

    Tetrahydro-4H-Pyran-4-one (29943-42-8)Uses

    It is an intermediate used in the preparation of the 4-methoxytetrahydropyran-4-yl protecting group.

    • Synthesizing symmetric tetrasubstituted methanes

    Hazards Associated with Tetrahydro-4H-Pyran-4-one (29943-42-8)

    GHS classification symbols

    • Highly flammable
    • Causes skin allergies such as reddening, soreness, dermatitis, or acute cyanosis
    • Respiratory tract irritation including dizziness, suffocation, nausea, or pulmonary edema
    • Eye irritation, which may cause permanent damage to the cornea
    • Upon ingestion, it may lead to vomiting, diarrhea, or Central Nervous System depression

    Tetrahydro-4H-Pyran-4-one (29943-42-8) Safety Measures

    Personal Protection

    Wear appropriate protective gears to prevent accidental contact with tetrahydro-4h-pyran-4-one or inhalation of the vapors. Use heavy rubber gloves, impervious footwear, and a face mask. The mask should be equipped with an approved full-face respirator with air filters and purifiers.

    1. Tetrahydro-4H-Pyran-4-one (29943-42-8)Engineering Controls

    Your laboratory should be well-equipped with an extinguisher, fume hood, fans, exhaust ventilation, convenient safety showers, and air cleaning devices.

    2. First Aid Measures


    Transfer the victim to an open area with enough ventilation or fresh air. In case of breathing difficulties, administer artificial respirations or oxygen support. Get medical support if the emergency measure fails.

    Skin contact

    Rinse the area immediately with plenty of water and non-abrasive soap for about 15 minutes. If the clothing has the spillages, take them off and wash before reuse. Seek further medical aid if soreness persists.

    Eye contact

    Wash the eyes with a lot of water for about 15 minutes. Seek aid from a physician if the symptoms persist, since this might lead to permanent damage.


    Seek immediate medical attention if the victim is unconscious. When conscious, thoroughly wash the mouth and drink a half liter of water or milk. Never attempt to induce vomiting.

    3. Tetrahydro-4H-Pyran-4-one (29943-42-8) Storage

    29943-42-8 is a combustible liquid. Ensure to keep it away from open flames, sparks, heat, or any other potential source of ignition. The storage condition should be cold, dry, and receive maximum ventilation. Ideally, storeTetrahydro-4H-Pyran-4-one within room temperature.

    Keep the product in a tightly closed container and remember to use the original packaging. Lock it up in a secure place to limit unauthorized access.

    4. Tetrahydro-4H-Pyran-4-one (29943-42-8) Handling

    When dealing with Tetrahydro-4H-Pyran-4-one, consider the following measures:

    • Work in an outdoor space or a room with adequate ventilation
    • Avoid inhaling fumes, vapors, or dust
    • Wear personal protective equipment to prevent Tetrahydro-4H-Pyran-4-one from getting into the eyes, respiratory tract, or skin
    • Do not use the chemical alongside explosive tools, heat, or flames
    • Ensure there’s availability of a safety shower and eyewash in your working area

    5. After using Tetrahydro-4H-Pyran-4-one (29943-42-8)

    After use, ensure to do the following:

    • Observe personal hygiene by washing hands and contaminated clothing
    • Eliminate the empty containers and chemical residues as per the waste disposal regulations
    • Store the remaining product under cold temperatures

    6. Tetrahydro-4H-Pyran-4-one (29943-42-8) Accidental Measures


    Use inert absorbent material to soak up the spill and toss it in a labeled waste container. Wash up the spot, ventilate it, and use a vapor-suppressor to reduce the vapors. Dispose of the contents according to the local or state’s waste disposal regulations.

    Fire Control

    In case of a fire outbreak, wear protective clothing before putting out the flame.A combination of Tetrahydro-4H-Pyran-4-one with other products may generate toxic fumes upon decomposition. Use a water spray, dry powder, foam, or CO2 gas.

    7. Stability of Tetrahydro-4H-Pyran-4-one (29943-42-8)

    Under standard conditions with normal pressure and temperatures, Tetrahydro-4h-pyran-4-one is quite stable. Exposure to strong oxidizing agents, acids or basesmay trigger decomposition. It decomposes into carbon monoxide, CO2, and other irritating gases.

    8. 29943-42-8 Waste Disposal

    ConsiderTetrahydro-4H-Pyran-4-one as special waste and dispose of per the local, federal, and the local regulations. You can also eliminate the product by burning it in a chemical incinerator.

    9. Tetrahydro-4H-Pyran-4-one (29943-42-8) Shipping Info

    Being a flammable product, Tetrahydro-4H-Pyran-4-one might be dangerous for transport. As a result, the shipping charges might be higher.

    29943-42-8 Regulatory Information

    Observe all the local and federal safety regulations, precautions, and precautions when handling Tetrahydro-4H-Pyran-4-one.

    29943-42-8 Technical Details

    Our dedicated scientists excel in all areas involving research, life and material sciences, chemical synthesis, analysis, and chromatography.

    Tetrahydro-4H-Pyran-4-one (29943-42-8) Bulk Ordering and Pricing

    Tetrahydro-4h-pyran-4-one is strictly for research, development, and chemical synthesis. If you require this product in bulk, feel free to make an order.


    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem Tetrahydro-4H-Pyran-4-one (29943-42-8) Sections 1-10.
    2. Conrad Weygand, Wiley, 1972 Weygand/Hilgetag Preparative Organic Chemistry, page 257-235
    3. Janice G. Smith, McGraw-Hill, 2008 – Chemistry, Organic, page 12-17

  2. Apicmo

    The best Tetrahydro-4H-pyran-4-one and service i have ever had,Nice experience

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