Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8)

(2 customer reviews)

This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of N-Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8) with quality control system under CGMP manufacturing



Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8) video

N-Boc-CIS-4-HYDROXY-L-PROLINE,Synonyms:BOC-CISHYP-OH;cis-boc-Hyp-OH;BOC-CIS-4-HYDROXY-L-PROLINE;cis-N-Boc-4-hydroxy-L-proline;N-BOC-CIS-4-HYDROXY-L-PROLINE;N-T-BOC-CIS-4-HYDROXY-L-PROLINE;(Tert-Butoxy)Carbonyl cis-Hyp-OH;N-Boc-cis-4-hydroxy-L-proline 97%;cis-N-Boc-4-hydroxy-L-proline, 97+%;(S,S)-CIS-1-N-BOC-4-HYDROXY-PROLINE.

N-Boc-CIS-4-HYDROXY-L-PROLINE  should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire. And store in closed vessels

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N-Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8) Specifications

CAS 87691-27-8
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD02094406
Chemical Name or Material N-Boc-CIS-4-HYDROXY-L-PROLINE
Infrared Spectrum Authentic
Physical Form Powder
Packaging Glass bottle
Molecular Formula C10H17NO5
Molecular Weight (g/mol) 231.248
Color White to off-white
Melting Point 146 °C
Assay 97%

APICMO hazard icons

N-Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8) Safety and Handling

(87691-27-8) GHS H Statement

  • Causes skin irritation
  • Causes serious eye irritation
  • May cause respiratory irritation
  • Very toxic to aquatic life


  • Avoid breathing dust/fume/gas/mist/vapours/spray
  • Avoid release to the environment.
  • IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
  • -Immediately wash skin with copious amounts of water for at least 15 minutes while removingcontaminated clothing and shoes. If irritation persists, seek medical attention. -Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention.
  • -Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

N-Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8) Articles

A medicine intermediate N – Boc – cis -4 – hydroxy – L – proline preparation method (by machine translation)

The present invention provides a pharmaceutical intermediate N – Boc – cis – 4 – hydroxy – L – proline preparation method, including L – hydroxy proline as raw materials, Boc protection on, then hydroxyl oxidation N – Boc – 4 – oxo – L – proline, finally dissolved in a solvent, under a certain temperature, and a reducing agent to obtain the product.

Shanghai Qingsong Pharmaceutical Co., Ltd; Zhang, jian; Chen, Xiaona; Gao, Junfeng; Zhang, shubin; Tan, Zhouhong; Duan, XingXing – CN106543062, 2017, A

Patent Family Members: CN106543062 A

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

N-Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8) Bulk Ordering & Pricing:

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2 reviews for Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8)


    Do you need N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 in large or small quantities? APICMO is a renowned company that produces, synthesizes and manufactures large quantities of N-Boc-4-hydroxy-L-proline, Cis- among other chemicals.

    At APICMO, we assure you of superior products as all our products comply with CMPG regulations on quality control and all other manufacturing regulations. We ensure that all our products are of the highest standards and quality. 87691-27-8 is in the chiral compounds category.

    What are Chiral Compounds?

    These are vital components in any discussion on stereochemistry in both inorganic and organic chemistry. Most biological active molecules are in chiral group; they include sugars and protein building blocks which are amino acids occurring naturally. They play a significant role as intermediates in manufacturing pharmaceuticals.

     N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Related Categories

    Compounds in similar categories include;

    • Unnatural amino acids and their derivatives
    • Proline derivatives
    • Chemical synthesis
    • Peptide chemistry
    • Chemical biology.

     N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Synonyms

    All the names listed below refer to the same product whose CAS number is 87691-27-8.

    • Cis-N-Boc-4-hydroxy-L-proline
    • (2S,4S)-cis-1-N-Boc-4-hydroxy-proline
    • Cis-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
    • N-Boc-cis-4-Hydroxy-L-proline
    • (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
    • Boc-cis hyp-oh
    • Boc-cis-4-hydroxy-l-proline
    • Boc-cis-4-Hyp-OH
    • (2S,4S)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
    • (2S,4S)-1-tert-butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid
    • n-t-boc-cis-4-hydroxy-l-proline
    • (4S)-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline
    • 1,2-pyrrolidinecarboxylic acid, 4-hydroxy-, 1-(1-1-dimethylethyl) ester, (2S,4S)-
    • boc-(2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid
    • N-Boc-cis-4-hydroxypyrrolidine-2-carboxylic acid
    • (2S,4S)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxy

    N-Boc-4-hydroxy-L-proline, cis- 87691-27-8 Structural Formula

    N-Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8)

    N-Boc-4-hydroxy-L-proline, cis- 87691-27-8 Chemical and Physical Properties

    With a molecular formula of C10H17NO5, 87691-27-8 has a formula weight of 231.25 g/mol and an exact mass of 231.111 g/mol.

    N-Boc-4-hydroxy-L-proline, cic- has a density of 1.312 g/cm3, a flash point of 190.2 degree Celsius and the refractive index of 1.531.

    The melting point for this product is 146 degree Celsius (D) (lit) with a boiling point of 390.9 degree Celsius at 760 mmHg.

    87691-27-8 appears a crystalline powder of white to off-white color and its purity is 97%. Ambient temperatures are necessary for this product.

    N-Boc-4-hydroxy-L-proline, cis- 87691-27-8 Computed Properties

    Property Name Property Value
    Covalently-Bonded Unit Count 1
    Isotope Atom Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 2
    Heavy Atom Count 16
    Formal Charge 0
    Compound Is Canonicalized Yes
    XLogP3-AA 0.3
    Monoisotopic Mass (g/mol) 231.111
    Topological Polar Surface Area 87.1A^2
    CACTVS Substructure Key Fingerprint AAADceByOAAAAAAAAAAAAAAAAAAA
    Complexity 296
    Rotatable Bond Count 3
    Hydrogen Bond Acceptor Count 5
    Hydrogen Bond Donor Count 2


    N-Boc-4-hydroxy-L-proline, cis- 87691-27-8 Synthesis Route

    There are 13 ways in which N-Boc-4-hydroxy-L-proline, cis- 87691-27-8 may be synthesized as shown below;

    Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8)

    Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8)

    Boc-CIS-4-HYDROXY-L-PROLINE (87691-27-8)

    N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Applications

    87691-27-8 is used as an intermediate in the manufacturing of pharmaceuticals.

     N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Potential Health Hazards

    87691-27-8 is toxic if ingested, inhaled or in contact with eyes or the skin. It’s also very harmful to aquatic life.

    Inhalation of this product may irritate the respiratory tract; do not breathe vapors, dust, spray, fumes, or gas.

    Swallowing 87691-27-8 may irritate the digestive system; do not smoke, eat or drink when handling this product.

    87691-27-8 may be very toxic to aquatic life; do not discharge this product to the environment.

    Contact of this product with eyes will cause severe eye irritation, while direct contact with the skin will irritate the skin. 

    N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Safety Measures

    First Aid Measures


    If you accidentally swallow 87691-27-8, wash out your mouth with plenty of water for about 15 minutes. If the victim is unconscious, do not give anything orally. Seek medical attention from a doctor or physician.


    If a victim breathes this product in the form of gas, vapor, mist, spray or dust, remove from the area of exposure. Bring the victim to an area with a sufficient flow of fresh air or to a well-ventilated room. Place the victim comfortably to ease breathing.

    In case breathing has stopped or is difficult, give artificial respiration; never give mouth-to-mouth resuscitation for a chemical victim.


    For eye contact, cautiously rinse your eyes with copious amount of water for about 15 minutes. Lift the upper and the lower eyelids occasionally to ensure you wash out as much chemical as you can. If you have contact lenses and are easy to remove do so as and continue rinsing. Seek immediate medical care or advice.

    For direct contact with the skin, flush the affected skin with plenty of running water using a mild soap for about 15 minutes. Remove any contaminated clothing or shoes as you continue cleaning. Seek immediate medical care or advice if the irritation persists. Thoroughly wash the contaminated clothes and shoes before reuse. 

    N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Handling, and Storage


    Handle this product strictly under the supervision of suitably qualified persons; who should put into account health and chemical hazards as well as the fire that may emanate from handling this product.

    N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Engineering Control

    Ensure you always use N-Boc-4-hydroxy-L-proline, Cis- in a chemical fume hood.

    Avoid generating and accumulating dust when handling 87691-27-8. Provide adequate ventilation especially to areas where dust is likely to be formed.

    Personal Protection

    Use personal protective equipment to ensure you handle this product safely, and these should include;

    • Chemical-resistant gloves or gauntlets to protect your hands from contact with N-Boc-4-hydroxy-L-proline, Cis-. Ensure the gloves are inspected before you use them. Employ the appropriate technique for gloves removal; do not touch the exteriors of the used gloves. Comply with applicable laws and good laboratory practice when disposing of the contaminated gloves. Wash and dry your hands before you move to the next activity.
    • Wear a lab coat or impervious protective clothing that suits the danger and the concentration of the chemical you are handling.
    • Wear approved safety goggles to shield your eyes from 87691-27-8. The glasses should have side-shields that conform to government standards like EN 166 (EU) or NIOSH (US).
    • Ensure you wear an approved respirator or a mask to avoid inhaling gas, mist, vapors, dust or spray from this product especially when handling large quantities.
    • Limit exposure to this product and do not exceed the airborne threshold levels.
    • Wash your hands before breaks and after the workday.
    • Take a bath after handling 87691-27-8 for personal hygiene.

     N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Storage

    Tightly close the container and keep it locked in a cool, dry and well-ventilated place.

    You may also keep 87691-27-8 in a refrigerator.

     N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Stability and Reactivity

    87691-27-8 is generally stable when stored under the recommended conditions. Keep it away from an oxidizing agent and avoid sparks, flames, and heat.

    Potential hazardous combustion products are Nitrogen Oxides and Carbon Monoxide. 

    N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Disposal Method

    For product

    You may call a licensed waste disposal firm to collect it as a special waste. This company must comply with local waste disposal authority regulations as well as those of regional and national authorities. Alternatively, you may use an incinerator with flue gas and a scrubber to burn it.

    For Contaminated Packaging

    Triple rinse these containers the offer them for recycling or reconditioning. Alternatively, puncture the contaminated container to render them unusable for other uses then dispose of in a sanitary landfill.

    Spillages or leakages

    This product is very toxic to aquatic life; do not discharge it to the environment. Never allow 87691-27-8 to flow in to sewer systems or water drainage. Do not contaminate seed, feed, water or foodstuffs either by disposal or storage.

    For spills, mix with an inert absorbent material such as sand or vermiculate, sweep up, collect and place in a well-labelled container ready for disposal; keep the container tightly closed.

     N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Fire Fighting Measures

    In case a fire involving this product whether alone or with other materials, use alcohol-resistant foam, dry powder, carbon dioxide or water spray to extinguish the fire. Do not use a water jet or straight water stream to quench the fire.

     N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Transportation Info

    87691-27-8 is safe for ground and air transportation. 

    N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Regulatory Info

    All chemicals in this material are not subject to SARA’s Title III, Section 302 reporting requirements and their CAS numbers do not exceed SARA’s Title III, Section 313 reporting threshold levels.

    Technical Service

    At APICMO, we have excellent scientists who are experts in various fields of research and have experience in Chromatography, Life Science, Material Science, Chemical Synthesis, Analytical and much more. 

    N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 Bulk Ordering and Pricing

    Whether you need large quantities of N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8 for manufacturing, research or development; get to us through our team of dedicated and friendly customer care and place your order with us. You can rest assured we will deliver exactly what you need and also on time.


    1. National Centre For Biotechnology Information, US. National Library Of Medicine, PubChem,N-Boc-4-hydroxy-L-proline, Cis- 87691-27-8, Sections 1-9.
    2. Mollica, Adriano; Paradisi, Mario Paglialunga; Varani, Katia; Spisani, Susanna; Lucente, Gino Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 7 p. 2253 – 2265
    3. Chapal, Nicolas; McNicol, Patricia; Jette, Lucie Patent: US2006/223884 A1, 2006; Location in patent: Page/Page column 60 ;
    4. GILEAD SCIENCES, INC.; DESAI, Manoj, C.; HUI, Hon Chung; LIU, Hongtao; SUN, Jianyu; XU, Lianhong Patent: WO2012/88156 A1, 2012 ; Location in patent: Page/Page column 60-61 ; WO 2012/088156 A1
  2. Apicmo

    The best Boc-CIS-4-HYDROXY-L-PROLINE and service i have ever had,Nice experience

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