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The ability to produce, synthesize and manufacture large quantities of N-Boc-cis-4-hydroxy-D-proline (135042-12-5) with quality control system under CGMP manufacturing
N-Boc-cis-4-hydroxy-D-proline (135042-12-5) video
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N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Specifications
|CAS Min %||95%|
|CAS Max %||100%|
|Chemical Name or Material||N-Boc-cis-4-hydroxy-D-proline|
|Molecular Weight (g/mol)||231.25|
|SMILES||CC(C)(C)OC(=O)N1C[[email protected]](O)C[[email protected]@H]1C(=O)O|
|Melting Point||146-151 °C|
N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Safety and Handling
(135042-12-5) GHS H Statement
- Causes serious eye irritation.
N-Boc-cis-4-hydroxy-D-proline GHS P Statement
- Wash skin thoroughly after handling
- Wear protective gloves/ eye protection/ face protection
- IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
- If eye irritation persists: Get medical advice/ attention.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Articles
An efficient new route for the preparation of (4R)-1-(tert-butoxycarbonyl)- 4-amino-D-proline
We have demonstrated an efficient new route for the preparation of (4R)-1-(tert-butoxy-carbonyl)-4-amino-D-proline from cis-4-hydroxy-D-proline by using very less costly available chemicals such as sodium azide and triphenylphospine for the first time in only four steps
Indian Journal of Heterocyclic Chemistry 2003 vol. 12 # 4 p. 381 – 382
A new synthetic method for the preparation of α,β-didehydroamino acid derivatives by means of a wittig-type reaction. Syntheses of (2S, 4S)- and (2R, 4R)-4-hydroxyprolines
Ethyl N-Boc- and N-Z-α-tosylglycinates were reacted with a variety of aldehydes in the presence of tributylphosphine and a base to afford the corresponding α,β-didehydroamino acid derivatives with high (Z)-selectivity in good yields. Moreover, ethyl (4S)- and (4R)-2-(N-Boc-amino)-4,5-isopropylidenedioxy-2-pentenoates prepared by the present method were converted to (2S, 4S)- and (2R, 4R)-4-hydroxyprolines, respectively.
Bulletin of the Chemical Society of Japan 2002 vol. 75 # 11 p. 2517 – 2525
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