N-Boc-cis-4-hydroxy-D-proline (135042-12-5)

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N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Specifications

CAS 135042-12-5
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD02094407
Chemical Name or Material N-Boc-cis-4-hydroxy-D-proline
Infrared Spectrum Authentic
Physical Form
Packaging Glass bottle
Molecular Formula C10H17NO5
Molecular Weight (g/mol) 231.25
SMILES CC(C)(C)OC(=O)N1C[[email protected]](O)C[[email protected]@H]1C(=O)O
Melting Point 146-151 °C
Assay 97%


N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Safety and Handling

APICMO hazard icons

(135042-12-5) GHS H Statement

  • H319
  • Causes serious eye irritation.

N-Boc-cis-4-hydroxy-D-proline GHS P Statement

  • P264+P280+P305+P351+P338+P337+P313
  • Wash skin thoroughly after handling
  • Wear protective gloves/ eye protection/ face protection
  • IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

  • If eye irritation persists: Get medical advice/ attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Articles

An efficient new route for the preparation of (4R)-1-(tert-butoxycarbonyl)- 4-amino-D-proline

We have demonstrated an efficient new route for the preparation of (4R)-1-(tert-butoxy-carbonyl)-4-amino-D-proline from cis-4-hydroxy-D-proline by using very less costly available chemicals such as sodium azide and triphenylphospine for the first time in only four steps

Indian Journal of Heterocyclic Chemistry 2003 vol. 12 # 4 p. 381 – 382

A new synthetic method for the preparation of α,β-didehydroamino acid derivatives by means of a wittig-type reaction. Syntheses of (2S, 4S)- and (2R, 4R)-4-hydroxyprolines

Ethyl N-Boc- and N-Z-α-tosylglycinates were reacted with a variety of aldehydes in the presence of tributylphosphine and a base to afford the corresponding α,β-didehydroamino acid derivatives with high (Z)-selectivity in good yields. Moreover, ethyl (4S)- and (4R)-2-(N-Boc-amino)-4,5-isopropylidenedioxy-2-pentenoates prepared by the present method were converted to (2S, 4S)- and (2R, 4R)-4-hydroxyprolines, respectively.

Bulletin of the Chemical Society of Japan 2002 vol. 75 # 11 p. 2517 – 2525

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Bulk Ordering & Pricing:

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2 reviews for N-Boc-cis-4-hydroxy-D-proline (135042-12-5)


    Too often you may not be sure of where to buy your good quality chemical products. Worry no more, at APICMO we provide you with the best buying experience you’ve ever had. We supply you with high purity chemical products at a highly competitive price. We are a leading pharmaceutical company that manufactures N-Boc-cis-4-hydroxy-D-proline (135042-12-5) among other chemical products. All our products conform to the Common Good Manufacturing Practice and other manufacturing regulations. Order from us today and let us provide you with world-class satisfaction.

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Chemical Structure

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5)

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Synthesis Route

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5)

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Precursor and Downstream Products


    N-Boc-cis-4-hydroxy-D-proline (135042-12-5)

    Downstream Products

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5)

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Synonyms

    • 135042-12-5
    • N-Boc-cis-4-Hydroxy-D-proline
    • Boc-cis-4-Hydroxy-D-proline
    • (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxy
    • (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carb
    • UNII-I467853HPL
    • I467853HPL
    • N-Boc-4-hydroxy-D-proline, cis-
    • (4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-D-p
    • (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarb

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Product Specifications

    Purity 98%
    Physical State Powder
    Monoisotopic Mass (g/mol) 231.111
    Molecular Weight (g/mol ) 231.248
    Molecular Formula C10H17NO5
    Melting Point 146-151 ˚c
    IUPAC Name (2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
    Density 1.312 g/cm^3
    Chemical Name N-Boc-cis-4-Hydroxy-D-proline
    Boiling Point 390.9 ˚c at 760 mmHg
    Flash Point 190.2 ˚c
    CAS no 135042-12-5

     N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Physical and Chemical Properties


    It is an off-white to the white powder.


    Covalent Bond 1
    Rotatable Bond 3
    Hydrogen Bond Acceptor-5



    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) is stable under normal conditions. It decomposes when subjected to high temperatures to produce nitrogen oxides, Carbon dioxide, and Carbon monoxide.

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Computed properties.

    Isotope Atom Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 2
    Heavy Atom Count 16
    Formal Charge 0
    Compound Is Canonized True
    XLogP3-AA 0.3
    Exact Mass 231.111 g/mol
    Topological Polar Surface Area  87.1 A^2
    Complexity 296

    Hazards associated with N-Boc-cis-4-hydroxy-D-proline (135042-12-5)APICMO hazard icons

    • It irritates the skin once in contact with it. It could cause skin reddening, blisters, and burning/itching.
    • It irritates the upper respiratory tract system once in contact. It may lead to nose congestion, sneezing, nasal discharge, sore throat, and a cough.
    • It irritates the eyes severely once it splashes in them. It may lead to eye reddening, watering, pain, and blurry vision.
    • It is toxic once ingested. It may cause vomiting, stomach pains/discomfort and lack of appetite.

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Safety Measures

    1. Personal protection

    Respiratory protection

    An assessment should be done to determine if there is any need to use air-purifying respirators for the task you are performing.  If it recommends its use, wear a dust mask of type N95 (US) or type P1 (EN 143) respirator. For higher level protection use type ABEK-P2 (EU EN143) or type OV/AG/P99 (US).  Always use tested and approved respirators under appropriate government standards such as CEN (EU) and NIOSH (US).

    Skin and body protection

    You should select the appropriate skin and body protection gear according to the amount and concentration of the hazardous substance at your workplace. For higher protection, use impervious boots and clothing. At the minimum, you should be in close-toed shoes and a lab coat.

    Eye protection

    To prevent any eye splashes, wear safety glasses with side shields conforming to EN I66. Ensure that you do a fit test to get glasses that are of your size to ensure their effectiveness. Use tested and approved eye protection wear under appropriate government standards such as EN 166 (EU) and NIOSH (US).

    Hands protection

    Wear protective gloves that satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Ensure that the gloves have no tears before wearing them. After use, remove them using the proper glove removal technique without coming into contact with the outer surface. Get rid of them immediately or clean them if they are reusable.

    2. N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Engineering controls

    • Install eye/body wash equipment in the vicinity of the working area. It will ensure a fast response in the event of an accident. The equipment helps flush off any splashes on the body and eyes and put off the fire on clothes if a fire occurs or body contact.
    • Ensure that there is adequate aeration in the area that you are working on especially in areas where the air supply is low, and where there is the formation of dust. Use of fume hoods and installation of local ventilation systems would do.
    • Comply with all national/local regulations put in place.

    3. First aid measures

    Following inhalation

    Remove the victim out of the area of exposure and get him to fresh air. Let them lie in a position that they can breathe comfortably. If they are not breathing, give them artificial respiration, if possible mouth-to-mouth. If they have difficulty in breathing, administer oxygen. Consult a doctor.

    Following skin contact

    Clean the material off the skin with a copious amount of running water and non-abrasive soap for a minimum of 15 minutes, as you remove any contaminated clothing or shoes. You can use cold water. Cover the affected area with an emollient. If itching, redness, burning sensation develops, seek the attention of a doctor immediately.

    Following eye contact

    Immediately flush the eyes with copious amount of water. If you are wearing contact lenses and they didn’t get off during the flush, remove them. Rinse under the eyelids too by separating them using your fingers. Ensure that your eyes are wide open. You can use lukewarm water. If itching, redness, burning sensation develops, look for a doctor to examine and treat your eyes.

    Following ingestion

    If the victim is conscious, let them use water to rinse out their mouth for at least 15 minutes. Do not give an unconscious victim anything through the mouth. You should not induce vomiting without the advice of a physician or a poison center.

    4. When using N-Boc-cis-4-hydroxy-D-proline (135042-12-5)

    Comply with all safety regulations regarding the use of chemical products. Use this product in a fume hood. Do not breathe the dust or vapors produced because they might be an irritant. Ensure that there is adequate aeration in the working area. Use only in a chemical fume-hood. Ensure that you are unsuitable protective gear. Do not eat, drink or smoke while using this product as it could lead to poisoning. Ensure that eyewash stations, safety showers, and spillage equipment are near you in case of an accident. Ensure that you use well-labeled containers for easier identification.

    5. After using N-Boc-cis-4-hydroxy-D-proline (135042-12-5)

    Return the chemical product in its storage area. Remove the protective gear and clean it, allow it to ventilate before wearing it again. Dispose of all containers and waste material properly. Clean the work surface to ensure that no spills are left out. Clean your hands thoroughly and dry them using a clean towel to avoid recontamination.

    6. When out of use

    Tightly seal the container with the remaining chemical product. Ensure that it is well labeled. Keep this product away from unauthorized, untrained or unqualified personnel. Once done with your operations, do not place the containers on bench tops to avoid knock-offs. Place it in a cool place that has sufficient ventilation, and that is far from fire sources and incompatible substances.

    7. N-Boc-cis-4-hydroxy-D-proline (135042-12-5) handling and storage


    Avoid skin and eye contact with this chemical product as it is an irritant. Avoid prolonged exposure. Use a lot of caution while handling this product. Avoid inhaling the vapor, mist, and fumes produced by this product. Do not smoke and keep the product away from any sources of ignition because it is flammable. Take measures that will help prevent the build-up of electrostatic charge. Do not let the product to enter into drains.


    Store the products away from incompatible substances to prevent any reaction from taking place. Store it while tightly capped to avoid spills. Do not consume or store food, drink or tobacco in areas where contamination by this chemical product may have occurred.

    8. N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Accidental measures


    Contain the spill using a suitable barrier to prevent it from flowing further. Wear an appropriate respirator, heavy rubber gloves, and impervious boots. Mix the substance with sand or similar inert absorbent material, scoop/vacuum/shovel it and transfer it into a suitable closable container ready for disposal. When done, clean the area and ventilate it. Wash the skin immediately with plenty of clean water and dry it. This chemical product should not get into drains or watercourses. If the spill is too much for you to handle, contact a waste disposal company for assistance.

    Fire control

    Get all uninvolved persons out of the scene. Move all portable containers to a safe place if it is possible and safe to do so. Wear self-contained breathing apparatus and protective garment to prevent contact with the skin and the eyes. Use any of the following extinguishing media:

    • Alcohol/ polymer foam
    • Dry chemical powder
    • Carbon dioxide

    9. Sensitivity and reactivity

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) reacts with strong oxidizing agents, strong acids and bases.

    10. Chemical disposal

    You can burn it in an incinerator fitted with a scrubber and an afterburner. Take extra caution while igniting it because this material is highly flammable. You could also offer surplus and non-recyclable solutions to a waste disposal company that is licensed.

    Another way is contacting a licensed waste disposal company to assist you in disposing of the chemical waste.

    11. Shipping information

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) is safe to transport by air, water, and road.

    N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Bulk pricing and ordering

    Whether you need it in small or large quantities, we got you covered. Contact us today for any inquiries that you may have.


    1. Chem Sources U.S.A, Directories Publishing Company, Incorporated, 2004, the University of Michigan, page 200.
    2. Progress in Medicinal Chemistry, Volume 34, page 23.3
    3. Dynamic Stereochemistry of Chiral Compounds: Principles and Applications, Christian Wolf, Georgetown University, Washington DC, page 204-304.
    4. National Centre For Biotechnology Information, US. National Library Of Medicine, PubChem, N-Boc-cis-4-hydroxy-D-proline, Sections 1-8.

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    The best N-Boc-cis-4-hydroxy-D-proline and service i have ever had,Nice experience

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