Description

APICMO offers a wide range of products which includes N-Boc-cis-4-hydroxy-D-proline (135042-12-5). It belongs to intermediates category. Contact us for more information.

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N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Specifications

CAS	135042-12-5
CAS Min %	95%
CAS Max %	100%
MDL Number	MFCD02094407
InChI Key	BENKAPCDIOILGV-RNFRBKRXSA-N
Chemical Name or Material	N-Boc-cis-4-hydroxy-D-proline
Infrared Spectrum	Authentic
Physical Form
Packaging	Glass bottle
Molecular Formula	C10H17NO5
Molecular Weight (g/mol)	231.25
SMILES	CC(C)(C)OC(=O)N1C[[email protected]](O)C[[email protected]@H]1C(=O)O
Color
Melting Point	146-151 °C
Assay	97%

 

N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Safety and Handling

(135042-12-5) GHS H Statement

• H319
• Causes serious eye irritation.

N-Boc-cis-4-hydroxy-D-proline GHS P Statement

• P264+P280+P305+P351+P338+P337+P313
• Wash skin thoroughly after handling
• Wear protective gloves/ eye protection/ face protection
• IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

• If eye irritation persists: Get medical advice/ attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

N-Boc-cis-4-hydroxy-D-proline (135042-12-5) Articles

An efficient new route for the preparation of (4R)-1-(tert-butoxycarbonyl)- 4-amino-D-proline

We have demonstrated an efficient new route for the preparation of (4R)-1-(tert-butoxy-carbonyl)-4-amino-D-proline from cis-4-hydroxy-D-proline by using very less costly available chemicals such as sodium azide and triphenylphospine for the first time in only four steps

Indian Journal of Heterocyclic Chemistry 2003 vol. 12 # 4 p. 381 – 382

A new synthetic method for the preparation of α,β-didehydroamino acid derivatives by means of a wittig-type reaction. Syntheses of (2S, 4S)- and (2R, 4R)-4-hydroxyprolines

Ethyl N-Boc- and N-Z-α-tosylglycinates were reacted with a variety of aldehydes in the presence of tributylphosphine and a base to afford the corresponding α,β-didehydroamino acid derivatives with high (Z)-selectivity in good yields. Moreover, ethyl (4S)- and (4R)-2-(N-Boc-amino)-4,5-isopropylidenedioxy-2-pentenoates prepared by the present method were converted to (2S, 4S)- and (2R, 4R)-4-hydroxyprolines, respectively.

Bulletin of the Chemical Society of Japan 2002 vol. 75 # 11 p. 2517 – 2525

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