5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6)

Rated 5.00 out of 5 based on 1 customer rating
(2 customer reviews)

This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of 5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) with quality control system under CGMP manufacturing
regulations.

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Description

5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) video

5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) Specifications

CAS 929617-35-6
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD11518975
InChI Key AVTKMQORQDZRPF-UHFFFAOYSA-N
Chemical Name or Material  5-bromo-1H-pyrazolo[3,4-c]pyridine
Infrared Spectrum Authentic
Physical Form White to brown solid
Packaging Glass bottle
Molecular Formula C6H4BrN3
Molecular Weight (g/mol) 198.03
SMILES C1=C2C=NNC2=CN=C1Br
Color White
Boiling Point 384°C at 760 mmHg
Assay 98%

At APICMO, we synthesize, produce, and manufacture large quantities of 5-Bromo-1H-pyrazolo(3,4-c) in compliance with the CGMP quality control system. Our products are mainly for research, development, and chemical synthesis.5-Bromo-1H-pyrazolo(3,4-c)pyridine falls under the same category with heterocycles, pyridines, and the related building blocks. Here’s the chemical structure of the product.


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2 reviews for 5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6)

  1. APICMO

    At APICMO, we synthesize, produce, and manufacture large quantities of 5-Bromo-1H-pyrazolo(3,4-c) in compliance with the CGMP quality control system. Our products are mainly for research, development, and chemical synthesis.5-Bromo-1H-pyrazolo(3,4-c)pyridine falls under the same category with heterocycles, pyridines, and the related building blocks. Here’s the chemical structure of the product.

    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6)

    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) Description

    The product is a pharmaceutical intermediate with an inhibiting effect against the epidermal growth factor receptor (EGFR) mutants.Activatingmutations at L858R position within the EGFR proteinat the kinase domain are responsible for exon 19 deletions.

    Just like the standard therapies like erlotinib and gefitinib,diaminopyrimidine inhibitorsreducetumor progression, thereby, increasing the survival rate.The inhibitory effect makes it a better treatment for non-small cell lung cancers. Mutation occurring at the EGFR protein kinase domain usually involves the substitution of threonine-790 with methionine, which exhibits resistance to erlotinib treatment.

    From an x-ray crystal structure of the inhibitory agents, two unique binding modes are disclosed, giving rise to a scientific design of diaminopyrimidine-based inhibitors. These products tend to be selective over kinases and wild-type EGFR. They also have a high inhibitory factor against T790M, and EGFR mutants.

    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) Product specifications

    Structural formula 5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6)
    Chemical name 5-Bromo-1H-pyrazolo(3,4-c)pyridine
    IUPAC name 5-Bromo-1H-pyrazolo(3,4-c)pyridine
    CAS no. 929617-35-6
    Molecular formula C6H4BrN3
    Molecular weight (g/mol) 198.023
    Density (g/cm3) 1.894
    Flash point (˚C) 186
    Boiling Point (˚C) 384 at 760 mmHg
    Melting point (˚C) 350
    Physical state Solid
    Purity 95% pure
    Synonyms · 1H-pyrazolo(3,4-c)pyridine, 5-Bromo

    · 5-Bromo-6-aza-1H-indazole

    · 5-Bromo-2H-pyrazolo(3,4-c)pyridine

    · 6-aza-5-Bromo-1H-indazole

    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) Computed Properties

    Property Name Property value
    Exact Mass (g/mol) 196.95900
    Monoisotopic mass (g/mol) 196.959
    Heavy Atom Count 10
    Isotope Atom Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Bond Stereocenter Count 0
    Formal Charge 0
    Compound Is Canonicalized Yes
    Complexity 130
    LogP 1.72040
    XLogP3-AA 1.5
    Surface tension (dyne/cm) 76.9
    Topological polar surface area 41.6 A^2
    Refractive index 1.745
    Enthalpy of vaporization (kJ/mol) 60.79
    Hydrogen bond Acceptor count – 3 units

    Donor count – 1 unit

    Covalent bond 1 unit
    Rotatable bond 0 counts

    Synthesis Route of 5-Bromo-1H-pyrazolo(3,4-c)pyridine

    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6)
    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6)

    Uses of 5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6)

    • Pharmaceutical intermediate
    • Research and development
    • Inhibitor of certain kinases

    Adverse Effects Associated with 5-Bromo-1H-pyrazolo(3,4-c)pyridine

    • Respiratory irritation
    • Skin corrosion when in direct contact with the body
    • Severe eye irritation
    • Causes acute toxicity if swallowed

    Safety measures when dealing with 5-Bromo-1H-pyrazolo(3,4-c)pyridine

    1. Personal Protection

    Wear protective clothing when working with 5-Bromo-1H-pyrazolo(3,4-c)pyridine to minimize the hazards associated with it. For face and eye protection, put on a mask and a respirator with air-purifying capabilities. Use chemical-resistant rubber gloves, safety goggles, and impervious footwear.

    2. Engineering Controls

    Work in a laboratory equipped with adequate exhaust ventilation, a safety shower, a chemical fume hood, and emission source isolation.These features should at least isolate the air contaminants by directing them away from the source.

    3. First Aid Measures

    Inhalation

    Breathing the chemical fumes may irritate the throat and cause discomfort in the chest. When this occurs, move the victim in a well-ventilated area or the outdoor space. If there are difficulties in breathing, use a breathing apparatus and seek advice from a professional.

    Skin contact

    Wash the affected area with plenty of running water and mild soap for several minutes. If the irritation persists, seek medical attention.

    Ingestion

    Thoroughly wash the mouth or drink up to half liters of water. Contact a poison center for further advice if the casualty experiences persistent oral soreness, nausea, or stomach pains.

    Eye contact

    If you have contact lenses, remove them before flushing the eyes with copious amount of cold water. Seek medical care in case of severe irritation, redness, or watery eyes.

    4. When Using 5-Bromo-1H-pyrazolo(3,4-c)pyridine

    As you handle this chemical, consider the precautions below:

    • Work in an outdoor space or a room with maximum ventilation
    • Wear appropriate protective clothing
    • Avoid breathing or inhaling dust or fumes
    • Use the fume hood

    5. After Use

    After using 5-Bromo-1H-pyrazolo(3,4-c)pyridine, observe the following measures:

    • Thoroughly wash the hands with enough water
    • Clean any contaminated clothing before reusing them
    • Dispose of the residues and empty containers as per the local chemical disposal regulation
    • Store the remaining product in a closed container

    6. When out of Use

    If you are not using the product, ensure the following:

    • Lock it up in the original package
    • Store under low temperatures of between 2 and 8˚C
    • Seal the container tightly to limit access
    • Keep the chemical in a well-ventilated area, away from moisture, heat, or flames

    7. Storage and Handling

    Storage

    • Store 5-Bromo-1H-pyrazolo(3,4-c)pyridine under low refrigeration temperatures (2 to 8˚C)
    • Sealit in a tight container
    • Lock the product in a secure place to limit access by unauthorized persons
    • The storage space should have enough ventilation
    • Maintain the original packaging

    Handling

    5-Bromo-1H-pyrazolo(3,4-c)pyridine is hazardous to the human health. Therefore, it requires an expert, the supervision of a professional, or anyone who’s aware of the chemical-handling procedures. The product is strictly for research, development, and chemical synthesis.

    Here are some of the preventive measures to take when working with 5-Bromo-1H-pyrazolo(3,4-c)pyridine:

    • Wear protective equipment
    • Work in a room with adequate ventilation, air cleaning devices, and fans
    • Use the chemical fume chamber
    • Avoid breathing the fumes

    8. Accidental Measures

    Spillages

    Do not release the chemical on the water channels and drainages. Scoop the solid chunks or use an absorbent material to pick up the spills and dispose of in a labeled container. Clean up the area with copious amount of water and soap.

    Fire control

    In case of fire, wear the appropriate apparatus and put out the flame with carbon dioxide, polymer foam, or dry powder. The combustion products emitted include oxides of nitrogen, carbon monoxide, carbon dioxide, and hydrogen bromide.

    9. Sensitivity and Reactivity

    Under normal conditions, 5-Bromo-1H-pyrazolo(3,4-c)pyridine is quite stable. However, avoid exposure to heat, strong acids, bases, and oxidizing agents since they may trigger chemical decomposition.

    10. Chemical Disposal

    Dispose of 5-Bromo-1H-pyrazolo(3,4-c)pyridine as a special waste as per the local and federal disposal regulations.

    11. Shipping Info

    There are no known hazards associated with either ground or air transportation

    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) Regulatory Info

    5-Bromo-1H-pyrazolo(3,4-c)pyridine abides by the federal, state and local laws governing the chemical threshold level. The above guide is not conclusive, and we cannot guarantee that the product has no other adverse effects rather than the ones mentioned.

    5-bromo-1H-pyrazolo[3,4-c]pyridine (929617-35-6) Bulk Ordering and Pricing

    Whether you need large or small quantities of this product for your development, manufacturing or research applications, Apicmo, is your best partner. Just contact our friendly and professional  customer care team for a free, no-obligation quote.

    Bibliography

    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem, 5-Bromo-1H-pyrazolo(3,4-c)pyridine, Sections 1-9.
    2. Yuchi Ma, Guangqiang Sun, Danqi Chen Med. Chem., 2015, 58(5), pp 2513–2529
    3. Naoki Katsuki, Shumpei Isshiki, Juan Okamura, Kouji Kuramochi, , and Kazunori Tsubaki The Journal of Organic Chemistry2017 82 (21), 11573-11584

  2. Rated 5 out of 5

    Apicmo

    The best 5-bromo-1H-pyrazolo[3,4-c]pyridine and service i have ever had,Nice experience

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