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The ability to produce, synthesize and manufacture large quantities of 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) with quality control system under CGMP manufacturing
2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Specifications
|CAS Min %||98%|
|CAS Max %||100%|
|Chemical Name or Material||2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine|
|Physical Form||Crystalline Solid|
|Molecular Weight (g/mol)||188.01|
Applications: It is used as a pharmaceutical intermediate.
Solubility: Soluble in DMSO, ethyl acetate and methanol. Slightly soluble in water.
Notes:Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE;2,6-Dichloro-7-deazapurine;2,6-dichloro-7-deazapurin ;2,4-DICHLORO-7H-PYROLO-[2,3-D]PYRIMIDINE;4,6-DICHLORO PURINE;2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine;2,4-Dichloro-7H-pyrrolo[2…;7H-Pyrrolo[2,3-d]pyriMidine,
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2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Safety and Handling
(90213-66-4) Hazard description:
♦ Causes skin irritation
♦ Causes serious eye irritation.
♦ May cause respiratory irritation
♦ Avoid breathing dust/fume/gas/mist/vapours/spray.
♦ If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.
♦ If in hand: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Articles
7-Deaza Isosters of 2′-Deoxyxanthosine and 2′-Deoxyspongosine – Synthesis via Glycosylation of 2,4-Dichloro-7H-pyrrolo<2,3-d>pyrimidine
Compound 5a was obtained by glycosylation of 2,4-dichloro-7H-pyrrolo<2,3-d>pyrimidine (3b) with the halogenose 4.Due to the reactivity of the chromophore halogens removal of the toluoyl residues by sodium methoxide resulted in rapid displacement of the chloro substituents which prevented the isolation of the free deoxyriboside of 3b and led to the 2,4-dimethoxynucleoside 7.
Liebigs Annalen der Chemie 1985
Synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine and 2,4-dichloro-7H- pyrrolo[2,3-d]pyrimidine
An efficient route to synthesize 4-chloro-7H-pyrrolo[2,3-d;]pyrimidine (6) and 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (10) starting from diethyl malonate in five steps with the total yields of 45.8percent and 44.8percent was disclosed in the presented paper.
Chinese Journal of Organic Chemistry 2010
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