2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4)

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The ability to produce, synthesize and manufacture large quantities of 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) with quality control system under CGMP manufacturing
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SKU: 90213-66-4 Category:

Description

2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) video

2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Specifications

CAS 90213-66-4
CAS Min % 98%
CAS Max % 100%
MDL Number MFCD08059278
InChI Key GHXBPCSSQOKKGB-UHFFFAOYSA-N
Chemical Name or Material 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine
Infrared Spectrum Authentic
Physical Form Crystalline Solid
Packaging Glass bottle
Molecular Formula C6H3Cl2N3
Molecular Weight (g/mol) 188.01
SMILES ClC1=NC(Cl)=C2C=CNC2=N1
Color Off-white
Melting Point 248.9-251.3°C
Assay ≥98%

Applications: It is used as a pharmaceutical intermediate.

Solubility: Soluble in DMSO, ethyl acetate and methanol. Slightly soluble in water.

Notes:Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Synonyms:

2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE;2,6-Dichloro-7-deazapurine;2,6-dichloro-7-deazapurin ;2,4-DICHLORO-7H-PYROLO-[2,3-D]PYRIMIDINE;4,6-DICHLORO PURINE;2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine;2,4-Dichloro-7H-pyrrolo[2…;7H-Pyrrolo[2,3-d]pyriMidine,

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2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Safety and Handling

APICMO hazard icons

(90213-66-4) Hazard description:

♦ Causes skin irritation

♦ Causes serious eye irritation.

♦ May cause respiratory irritation

Precautionary statement:

♦ Avoid breathing dust/fume/gas/mist/vapours/spray.

♦ If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice or attention.

♦ If in hand: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Articles

7-Deaza Isosters of 2′-Deoxyxanthosine and 2′-Deoxyspongosine – Synthesis via Glycosylation of 2,4-Dichloro-7H-pyrrolo<2,3-d>pyrimidine

Compound 5a was obtained by glycosylation of 2,4-dichloro-7H-pyrrolo<2,3-d>pyrimidine (3b) with the halogenose 4.Due to the reactivity of the chromophore halogens removal of the toluoyl residues by sodium methoxide resulted in rapid displacement of the chloro substituents which prevented the isolation of the free deoxyriboside of 3b and led to the 2,4-dimethoxynucleoside 7.

Liebigs Annalen der Chemie 1985

Synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine and 2,4-dichloro-7H- pyrrolo[2,3-d]pyrimidine

An efficient route to synthesize 4-chloro-7H-pyrrolo[2,3-d;]pyrimidine (6) and 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (10) starting from diethyl malonate in five steps with the total yields of 45.8percent and 44.8percent was disclosed in the presented paper.

Chinese Journal of Organic Chemistry 2010

Technical Service:

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2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Bulk Ordering & Pricing:

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2 reviews for 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4)

  1. APICMO

    At APICMO, we can produce, synthesize and manufacture large amounts of 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine with a quality control system under the CGMP manufacturing regulations.

    If you are looking for more substantial amounts of 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) for your research, development, and manufacturing applications contact us at [email protected] for a custom order.

    The IUPAC name for this product is 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine. 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine  is also  known as 1H-Pyrrolo[2,3-d]pyrimidine, or 2,4-dichloro- (9CI) or 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine or 7H-Pyrrolo[2,3-d]pyrimidine. It appears as a white solid.

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) What is a Pyrimidine?

    In simple terms, Pyrimidines are aromatic compounds with Nitrogen and Carbon atoms in a six-membered ring which is reasonably stable. Pyrimidine derivatives have played a critical role in the research and development of medicines either alone or in conjunction with other compounds. Here is the 3-D conformation for Pyrimidines in general:

    conformation for Pyrimidines in general

    Pyrimidine has been widely used, and continue to be used in a vast range of drugs, such as antimalarial drugs, anti epilepsy medication, medicines for the treatment of high blood pressure, general anesthetics, and also in HIV Medication synthesis.

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Synthesis of Pyrimidines

    As it is always the case with parent heterocyclic ring compounds, synthesis of pyrimidines is not that typical and is often achieved by removing functional groups from the derivatives.

    As a group, pyrimidines are often synthesized by principal synthesis that involves cyclization of β-dicarbonyl with N–C–N compounds. The reaction of the former with amidines gives two-substituted pyrimidines, an urea to provide 2-pyrimidinones, as guanidines to provide 2-aminopyrimidines are typical.

    Pyrimidines can be synthesized through the Biginelli reaction. Several other methods depend on the condensation of carbonyls with diamines. For example the preparation of 2-thio-6-methyluracil from ethyl acetoacetate and thiourea] or the preparation of 4-methylpyrimidine with formamide and 4,4-dimethoxy-2-butanone.

    A novel way is by reacting carbonitriles with N-vinyl and N-aryl amides under electrophilic activation of amides with trifluoromethanesulfonic anhydride and 2-chloro-pyridine.

    So far, we have discussed Pyrimidines in general, but on this particular post, we will mainly focus on 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4). So let’s now start narrowing down.

    The following is the chemical structure of 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4)

    Below are the computed physical and chemical properties of 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4).

    Property Name Property Value/ Statement
    Depositor-Supplied Synonyms

     

    2,4-dichloropyrrolo[2,3-d]pyrimidine

    1. 2,4-dichloro-1H-pyrrolo[2,3-d]pyrimidine

    1. 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

    2,6-Dichloro-7-deazapurine

    2,4-dichloro-7h-pyrrolo2,3-dpyrimidine

    Molecular Weight 188.011 g/mol
    Hydrogen Bond Donor Count 1
    Hydrogen Bond Acceptor Count 0
    Rotatable Bond Count 0
    Complexity 155
    Topological Polar Surface Area 41.6 A^2
    Monoisotopic Mass 186.97 g/mol
    Exact Mass 186.97 g/mol
    XLogP3-AA 2.6
    Compound Is Canonicalized True
    Formal Charge 0
    Heavy Atom Count 11
    Defined Atom Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Bond Stereocenter Count 0
    Isotope Atom Count 0
    Covalently-Bonded Unit Count 1

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Applications

    This product is used as a pharmaceutical intermediate more specifically, tasocitinib intermediate.

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Solubility

    The product is slightly soluble in water.

    It is soluble in ethyl acetate, methanol, and DMSO.

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Safety Measures

    Symbol(GHS):

    APICMO hazard icons

    1. Hazards identification

    No any known hazard.

    2. First aid measures

    a) Skin contact

    Promptly wash your skin with a lot of water for around fifteen minutes as you remove contaminated shoes and clothing. If the irritation persists, look for medical assistance.

    b. Eye contact

    Promptly wash your skin with a lot of water for around fifteen minutes. Ensure sufficient flushing of the eyes as you separate the eyelids with fingers. In case irritation persists, look for medical attention.

    c.  Inhalation

    Immediately remove to fresh air. If symptoms persist or during serious cases look for medical attention.

    d. Ingestion

    Immediately wash out your mouth with a lot of water for around 15 minutes. Then seek medical attention as soon as possible.

    3. Firefighting measures

    In case of a fire which involves this product, alone or in combination with several other products, use carbon dioxide extinguishers or dry powder. Self-contained breathing apparatus and protective clothing should be worn.

    4. Accidental release measures

    • Personal precautions: Put on the appropriate personal protective equipment that performs in a satisfactory manner and meets national, local, and state standards.
    • Respiratory precaution: Put on the approved respirator or mask
    • Hand precaution: Put on the appropriate gauntlets or gloves.
    • Skin protection: Put on the appropriate protective clothing.
    • Eye protection: Put on the appropriate eye protection.

    5.Ways of cleaning up

    Mix with a similar inert absorbent product or sand or sweep it up and keep the material in a well-closed container for disposal.

    6.Environmental precautions

    You should not let this product have its way to watercourses or enter drains.

    7. Handling and storage

    1. Handling: This material should always be handled under the close supervision of or only by those well qualified in the use and handling of potentially harmful chemicals, who should always take into consideration the health, chemical, and fire hazard data provided on this post.
    2. Storage

    This product should be stored in refrigerated and closed vessels.

    8. Personal protection and exposure controls

    • Engineering Controls: You should use this product in a chemical fume hood only.
    • Equipment for Personal protection: Put on safety goggles, laboratory clothing, and chemical-resistant gloves.
    • General hygiene measures: Clean your hands thoroughly after handling. Make sure that you clean contaminated clothing before reuse.

    9. 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Stability and reactivity

    You should always avoid the following conditions when handling this material:

    • Hea
    • Flames
    • Sparks

    You should also avoid the following materials when handling this product:

    • Possible hazardous combustion materials such as carbon monoxide, hydrogen chloride, and nitrogen oxides as well.
    • Oxidizing agents

    10. Disposal consideration

    Arrange for disposal as a special chemical waste in consultation with your local waste disposal authority, with the assistance of a licensed disposal company and, in accordance with regional and national regulations.

    11.Transportation information

    There is no known hazard for ground and air transportation

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Technical Service

    Our team of scientists has vast experience in all areas of research such as Life Science, Chemical Synthesis, Material Science, Chromatography, Analytical chemistry and much more.

    2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) Bulk Ordering and Pricing

    Whether you need large or small amounts of 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) either for your research, development, and manufacturing, APICMO is your best partner. Just contact us at king@apicmo.com.

    Biography

    1. Journal of medicinal chemistry 1988 Aug;31(8):1501-6
    2. Pub Chem NCBI. National Library of Medicine, 2, 4-Dichloro-7H-pyrrolo-2,3-d pyrimidine section of Computed Properties.
    3. Lythgoe, B.; Rayner, L. S. (1951). “Substitution Reactions of Pyrimidine and it’s 2- and 4-Phenyl Derivatives”. Journal of the Chemical Society. 1951: 2323–2329
  2. Rated 5 out of 5

    Apicmo

    The best 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine and service i have ever had,Nice experience

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