4-Amino-5-bromo-2-chloropyridine (857730-21-3)

(2 customer reviews)

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Description

4-Amino-5-bromo-2-chloropyridine (857730-21-3) video

4-Amino-5-bromo-2-chloropyridine is also 5-BROMO-4-CHLORO-2 -AMINOPYRIDINE. It is one of the pyridine compounds, and as an intermediate, it is useful. But Harmful if swallowed also harmful in contact with skin. So when you use it please bw careful.

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4-Amino-5-bromo-2-chloropyridine (857730-21-3) Specifications

CAS 857730-21-3
CAS Min % 95.0
CAS Max % 100.0
MDL Number MFCD09037459
InChI Key MGZWZNBANVSZLM-UHFFFAOYSA-N
Chemical Name or Material 4-Amino-5-bromo-2-chloropyridine
Physical Form Powder or Chunks
Packaging Glass bottle
Molecular Formula C5H4BrClN2
Molecular Weight (g/mol) 207.455
SMILES C1=C(C(=CN=C1Cl)Br)N
Melting Point 127° to 129°C
Assay 95%

4-Amino-5-bromo-2-chloropyridine (857730-21-3) Safety and HandlingAPICMO hazard icons

(857730-21-3) Hazard description:

  • Harmful if swallowed.
  • Harmful in contact with skin.
  • Causes skin irritation.
  • Causes serious eye irritation.
  • May cause respiratory irritation.

4-Amino-5-bromo-2-chloropyridine Precautionary statement:

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

4-Amino-5-bromo-2-chloropyridine (857730-21-3) Articles

Synthesis in vitro of new 2-thioxoimidazo[4,5-b]pyridine derivatives

wo series of 2-thioxoimidazo[4,5-b]pyridine derivatives have been synthesized from 2,3-diaminopyridine (1) and 5-halogenosubstituted-2,3-diaminopyridines 2, 3. Mannich bases 7 – 12 and 24 – 29 …

Pharmaceutica – Drug Research 2015

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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2 reviews for 4-Amino-5-bromo-2-chloropyridine (857730-21-3)

  1. APICMO

    Are you in need of a supply of large or small quantities of 4-Amino-5-bromo-2-chloropyridine 857730-21-3 that is of the highest quality in the market? Look no further as we got you covered. At APICMO, we produce, synthesize and manufacture large quantities of 4-Amino-5-bromo-2-chloropyridine among many other chemicals.

    We assure you of the highest standards and quality as all our products adhere to CMPG regulations on quality control and all other manufacturing laws and regulations. 4-Amino-5-bromo-2-chloropyridine is in the same category as heterocyclic building blocks, halogenated heterocytes, building blocks, C5, chemical synthesis, and pyridines.

    What is pyridine?

    Pyridine is a basic organic compound of the heterocyclic group. Pyridine and its derivatives are very critical for their medical and non-medical uses for they have significant applications in different fields.

    In the medical field, pyridine and its derivatives have become increasingly important in modern medicine application. They have a broad-spectrum capability in biological applications where they act as;

    • Anti-inflammatory agents.
    • Anti-malarial agents.
    • Anti-diabetic.
    • Antioxidants
    • Anti-cancer activities.
    • Anti-viral.
    • Anti-microbial.
    • Anti-amoebic agents.
    • Enzyme inhibitors.
    • Psychopharmacological antagonistic.
    • Medicine for iron overload disease.

    4-Amino-5-bromo-2-chloropyridine 857730-21-3

    4-Amino-5-bromo-2-chloropyridine (857730-21-3)

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Synonyms

    All the following names refer to the same product, and they include;

    • 5-Bromo-2-chloropyridin-4-amine.
    • 5-Bromo-2-chloro-pyridin-4-ylamine.
    • 2-chloro-5-bromo-4-aminopyridine.
    • 2-chloro-5-bromo-pyridine-4-ylamine.
    • 5-bromo-2-chloro-4-pyridinamine.
    • 2-chloro-5-bromo-4-aminopyridine.

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Chemical and Physical Properties

    With a molecular formula of C5H4BrCIN2, 4-Amino-5-bromo-2-chloropyridine has a molecular weight of207.46 g/mol with an exact mass of 205.92500 g/mol.

    Its density is 1.834 g/cm3 and the refractive index 1.648. The PSA  and LogP are 38.91000 and 2.66090.

    4-Amino-5-bromo-2-chloropyridine appears as chunks and powder form.

     4-Amino-5-bromo-2-chloropyridine 857730-21-3 Computed Properties

     

    Property Name

     

    Property Value

     

    Covalently-bonded unit

     

    1

     

    Rotatable Bond count

     

    0

     

    Hydrogen Bond Donor Count

     

    1

     

    Hydrogen Bond Acceptor Count

     

    2

     

     

    XlogP3-AA

     

     

    1.8

     

    Monoisotopic Mass (g/mol)

     

    205.925

     

    Compound Is Canocalized

     

    Yes

     

    Defined Bond Stereocentre Count

     

    0

     

    Defined Atom Stereocentre Count

     

    0

     

    Undefined Bond Stereocentre Count

     

    0

     

    Undefined Atom Stereocentre Count

     

    0

     

    Topological Polar Surface Area

     

    38.9 A^2

     

    Isotope Atom Count

     

    0

     

    Formal Charge

     

    0

     

    Heavy Atom Count

     

    9

     

    Purity

     

    97%

     

    Complexity

     

    101

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Synthesis Route

    4-Amino-5-bromo-2-chloropyridine (857730-21-3)

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Applications

    857730-21-3 is used as pharmaceutical intermediates.

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Health Hazards

    • 857730-21-3 may be harmful if swallowed as it may irritate the digestive tract.
    • Direct contact of 4-Amino-5-bromo-2-chloropyridine with the skin may cause skin irritation.
    • Breathing or inhaling 857730-21-3 may irritate the respiratory tract system.

    Any contact of 4-Amino-5-bromo-2-chloropyridine with eyes may cause severe eye irritation and damage. 

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Safety Measures

    First Aid Measures

    For Inhalation

    Immediately evacuate the victim from the source and bring them to an open area with sufficient flow of fresh air; alternatively, take the victim into a well-ventilated room.

    Administer artificial respiration if the victim is not able to breathe or has difficulty on the same. Never attempt to give mouth-to-mouth resuscitation where chemicals are involved.

    For Ingestion

    If you or anyone else accidentally swallows 857730-21-3, do not induce vomiting unless advised otherwise by qualified medical personnel.

    Wash your mouth generously with a copious amount of water and do this for at least 15 minutes. If the victim is unconscious, do not give anything by mouth. Seek for medical attention or advice soonest possible.

    For Contact

    If 857730-21-3 comes in contact with your eyes, flush immediately with plenty of running water. As you do this, occasionally lift the upper and the lower eyelids to ensure you wash away as much chemical as you can.

    Remember to remove contact lenses if you have them and are easy to remove even as you continue flushing. Immediately rush to a health facility for medical advice and aid.

    If you have direct contact of 4-Amino-5-bromo-2-chloropyridine 857730-21-3 with your skin, use a mild soap and plenty of running water to wash the affected skin.

     4-Amino-5-bromo-2-chloropyridine 857730-21-3 Handling and Storage

    Handling

    Whenever you are handling this product, ensure you wear the appropriate protective gears for personal protection and safety.

    Ensure you wear a dust mask especially when handling large quantities of 857730-21-3 to avoid inhaling this product.

    When handling this product, do not generate dust or form aerosols. Avoid breathing dust, gas, vapors, and mist. Always limit the exposure time with this product. Always ensure there is adequate ventilation in areas of utilization and storage of 857730-21-3.

    Wear safety glasses that are approved and chemical resistant to shield your eyes from contact with this product. The safety glasses should have side-shields that conform with the appropriate government standards like EN 166 (EU) or NIOSH (US).

    Wear impervious clothing when handling this product to prevent contact with your skin. Select the protective garment while considering the quantity of the dangerous substance, and the concentration of the chemical being handled at a specific workplace.

    Wear impervious gloves that are chemical-resistant to protect your hands from direct contact. Ensure the gloves are inspected before you use them. These gloves must satisfy EU Directive 89/686/EEC specifications and EN 374 standards that are derived from the same.

    Remember to use the right technique to remove gloves after use; avoid touching the outer surface of the contaminated gloves so that there is no direct contact with the chemical.

    When disposing of the contaminated gloves, comply with applicable laws and follow good laboratory practices. Lastly, wash and dry your hands before you move to the next activity.

    Always handle this product in accordance with the safety practice and good industrial hygiene.

    Storage

    Keep in a tightly closed container and store in a cool, dry place that is well-ventilated.

     4-Amino-5-bromo-2-chloropyridine 857730-21-3 Disposal Methods

    Arrange for disposal by a professional and licensed destruction plant after consulting your local authority. Alternatively, incinerate in a chemical incinerator that is fitted with flue gas and a scrubber.

    Do not contaminate feed, seed, foodstuffs or water either by disposal or storage.

    Do not discharge this product into the environment; Do not allow it to flow into the water drains or enter the sewer systems.

    In case of spillage or leakage, avert more leakage and spillage. Sweep up and use a shovel to collect the waste into a labeled container for disposal.

    For contaminated containers, triple rinse before offering for reconditioning and recycling. Alternatively, puncture the packaging to render it unusable for any other use then put in a sanitary landfill for disposal.

     4-Amino-5-bromo-2-chloropyridine 857730-21-3 Fire-fighting Measures

    In the event of a fire involving this product either alone or with other products, use dry powder, carbon dioxide or water spray to put off the fire. Never use a water jet in this kind of fire.

    A fire from chemicals is likely to produce toxic gases from combustion decomposition; always wear appropriate protective gear before you start engaging the fire. Remember to equip yourself with a self-contained breathing apparatus to ensure you have enough supply of oxygen.

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Stability and Reactivity

    857730-21-3 is generally stable when stored at the recommended conditions.

    Technical Service

    We at APICMO pride in our team of experts who are highly qualified and experienced in Life Science, Chemical Analysis, Material Science, and Chromatography to mention a few. They ensure all our products are of the highest standards and quality. 

    4-Amino-5-bromo-2-chloropyridine 857730-21-3 Bulk Ordering and Pricing

    Do you need a bulk supply of highest quality 4-Amino-5-bromo-2-chloropyridine 857730-21-3, you can rest easy since we at APICMO will sort you out. Contact our dedicated and friendly customer care team and place your order.

    Bibliography

    1. George Richard Newkome, Lucjan Strękowski, Piotr Tomasik, Zbigniew Ratajewicz, Pyridine and Its Derivatives, Volume 14, Part 2.
    2. A. Abramovitch, John Wiley & Sons, 22 Feb 197, Heterocyclic compounds, The Chemistry of Heterocyclic Compounds, Pyridine and Its Derivatives: Supplement.
    3. National Centre For Biotechnology Information, US. National Library Of Medicine, PubChem,4-Amino-5-bromo-2-chloropyridine, 857730-21-3,  Sections 1-9.

  2. Apicmo

    The best 4-Amino-5-bromo-2-chloropyridine and service i have ever had,Nice experience

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