6-Bromopurine (767-69-1)

(2 customer reviews)

This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of 6-Bromopurine (767-69-1) with quality control system under CGMP manufacturing
regulations.

SKU: 767-69-1 Category:

Description

6-Bromopurine (767-69-1) video

6-Bromopurine (767-69-1) Specifications

CAS 767-69-1
CAS Min % 98%
CAS Max % 100%
MDL Number MFCD00022648
InChI Key CTGFGRDVWBZYNB-UHFFFAOYSA-N
Chemical Name or Material 6-Bromopurine
Infrared Spectrum Authentic
Physical Form crystalline powder
Packaging Glass bottle
Molecular Formula C5H3BrN4
Molecular Weight (g/mol) 199.011 g/mol
SMILES C1=NC2=C(N1)C(=NC=N2)Br
Color Pale yellow powder
Melting Point >300 °C
Assay 98%-100%

At APICMO, our scientists have vast experience in chemical synthesis, analytical chemistry, life sciences, and the related scientific work. We produce large quantities of 6-Bromopurine, which is aimed for research, development, and synthesis of other chemicals.


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2 reviews for 6-Bromopurine (767-69-1)

  1. APICMO

    At APICMO, our scientists have vast experience in chemical synthesis, analytical chemistry, life sciences, and the related scientific work. We produce large quantities of 6-Bromopurine, which is aimed for research, development, and synthesis of other chemicals.

    6-Bromopurine (767-69-1)

    The product will synthesize 6-halopurine alkynes, 2,3,4,5-tetrahydro-1,5-benzoxazepines-3-ol, and triazole derivatives. It falls in the same categories as halogenated heterocycles, building blocks, purines, and chemical synthesis.

    The activity of azaserine in a test system using ascites cell forms of Ehrlich carcinoma  and sarcoma 180  in vivo.

    6-bromopurine nucleosides are great substrates for substitution reactions with O-, S-, and N-containing nucleophiles in polar solvents. Towards the formulation of new class of podophyllotoxin to target tubulin and topoisomerase II as substantial target in cancer therapy, a series of isoxazolidine podophyllotoxin derivatives were designed. Four β-tubulin in complex with taxol, vinblastine, colchicines or zampanolide, and topoisomerase in complex with etoposide were used as targets using GOLD5.2.2 as the docking module.

    The revealed important structural characteristics of the fitness into tubulin domain have been discussed as follows:

    1. Trans orientation of the lactone (ring D) with 5a-β, 8a-α configuration;
    2. Dioxolane in ring A;
    3. Free rotation of ring E;
    4. α (R) or β (S) configuration has equal fitness in position 5;
    5. 4′-OMe;
    6. Phosphoramide linkage;
    7. Ethylene bridge between the isoxazolidine and phosphate ring;
    8. Benzyl moiety at N2-position of isoxazolidine ring; and
    9. Position 5 of isoxazolidine ring accommodated with N-(2-oxopyrimidin-4-yl) acetamide, 6-bromo-9H-purine, or 2-amino-6H-purin-6-one.

    All these structural characteristics are crucial for compounds to fit correctly  into topoisomerase II, except (1) β (S) configuration has a higher score fitness than α (R) in position 5; (2) 4′-OH; and (3) position 5 of isoxazolidine ring accommodated better with 7H-purin-6-amine,  6-bromo-9H-purine or 2-amino-6H-purin-6-one . Toxicity studies and computational ADMET were in agreement with the docking results. The Compounds holding ethylene bridge between benzyl moiety and phosphate at N2-position of isoxazolidine ring have the maximum pharmacokinetic properties and were taken to be non-toxic. The expected solubility profile for most of 4′-OMe with compounds was excellent. This made us realize our aim in identification of promising new hints as an antitumor agent with less toxicity and improved activity.

    Product Specifications

    Chemical name 6-Bromopurine
    IUPAC name 6-bromo-7H-purine
    Molecular formula C5H3BrN4
    CAS no. 767-69-1
    Synonyms · 6-bromo-7H-purine

    · Purine, 6-bromo-

    · Bromopurine

    · 1H-purine, 6-bromo-

    · 6-Bromo-1H-purine

    · 6-bromo-9H-purine

    · 9H-purine, 6-Bromo

    Molecular weight (g/mol) 199.011
    Formula weight (g/mol) 199.01
    Structural formula 6-Bromopurine (767-69-1)
    Physical state Crystalline solid
    Purity 98%
    Melting point (˚C) >300
    Boiling point (˚C) 450 at 760 mmHg
    Flash point (˚C) 260
    Density (g/cm3) 1.7

    Chemical and Physical Properties of 6-Bromopurine

    Solubility

    6-Bromopurine is slightly soluble in methanol and dimethyl sulfoxide.

    Appearance

    The chemical exists in the form of paleyellow powder

    Bonding

    Rotatable bond 0
    Covalent 1 unit
    Hydrogen bond Donor count – 1 unit

    Acceptor count – 3 units

    Sensitivity

    6-Bromopurine is highly sensitive to heat, light, and moist conditions.

    Computed Properties

    Property Name Property Value
    Exact Mass (G/Mol) 197.954
    Monoisotopic mass (g/mol) 197.954
    Defined Atom Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Isotope Atom Count 0
    Heavy Atom Count 10
    Compound Is Canonicalized Yes
    Formal Charge 0
    Complexity 131
    Refractive index 1.740
    Topological Polar Surface Area 54.5 A^2
    Xlogp3 1.3
    Molar refractivity (cm3) 38

    Application of 6-Bromopurine

    • Synthesis of 6-halopurine and their triazole derivatives
    • Synthesizing 2,3,4,5-tetrahydro-1,5-benzoxazepines-3-ol
    • Chemical characterization of 2,3,4,5-tetrahydro-1,5-benzoxazepines-3-ol
    • Pharmaceutical intermediate

    Risks Associated with Poor Handling of 6-Bromopurine

    APICMO hazard icons

    Before handling 6-Bromopurine, you should be aware of the hazards and the dangers it may have on your health.

    • Causes skin sensitization or severe irritation when in direct contact with the body
    • Severe toxicity with inhalation or ingestion
    • Respiratory irritation if inhaled
    • Severe eye irritation which might lead to acute damage

    Safety Measures When Handling 6-Bromopurine

    1. Engineering controls

    These methods are the most reliable, permanent, and sure way of minimizing hazards in a chemical-based laboratory. They include exhaust ventilation, chemical fume hood, emission source enclosure, process control, and a convenient safety shower.

    Exhaust ventilation

    This system can either filter out the contaminated air or direct it away from the user. It includes an air cleaning device, recirculation duct, or a fan.

    Chemical fume hood

    This chambers traps the air contaminants

    Emission source enclosure

    Work in an enclosed space which separates the chemical from the user. The enclosure should be well-sealed to prevent access by unauthorized personnel.

    2. Personal Protection

    Cover your entire body with the appropriate clothing. For face protection, use the safety goggles, a fitting mask, anda respirator with air-purifying capabilities. Wear chemical- resistant rubber gloves, impervious shoes, and a full suit.

    3. First Aid Measures

    Eye contact

    If you have any contact lenses, remove them and immediately rinse the eyes with plenty of running water for about 10 minutes. Seek medical attention if irritation persists.

    Skin contact

    Wash the spot with a copious amount of running water to prevent corrosion. Continue flushing the affected area for the next 15 minutes before seeking further medical advice.

    Ingestion

    Move the victim in an open area or a room with maximum air ventilation. Administer oxygen support if there are breathing difficulties and seek immediate medical care.

    Ingestion

    Flush the mouth with enough water and seek medical advice to minimize toxicity.

    4. When using 6-Bromopurine

    When in use, take the following precautions:

    • Work in a well-ventilated room
    • Wear suitable protective equipment
    • Avoid inhaling dust or fumes
    • Use a chemical fume hood

    5. After use

    After using 6-Bromopurine, take note of the following:

    • Dispose of the end products according to your area’s local and federal laws
    • If the chemical remains for future use, store it up in a cool and dry place
    • Wash hands thoroughly with running water and mild soap
    • Wash the contaminated clothing  before reusing
    • In case of spillages, clean the working bench and dispose of the residues as per the chemical waste disposal regulations
    • Do not allow 6-Bromopurine to flow in the drainage

    6. When not in use

    • Store in a tightly closed container
    • Lock it up in a sealed cabinet to prevent access to unauthorized personnel
    • Keep the product under low temperatures

    7. Storage and Handling

    Handling

    6-Bromopurine should be handled by a professional or an expert who understands the risks involved. Always wear the protective attires such as a respirator to avoid inhaling the toxic fumes. In this case, bromine is poisonous to the respiratory tract when inhaled.

    Storage

    Store the product under low temperatures in a room with enough ventilation. Preferably, this should be in a refrigerator at -20˚C. Limit exposure to light or moisture.

    8. Firefighting measures

    In case of fire, contain the inferno with dry powder, alcohol, polymer foam, or carbon dioxide gas. Avoid breathing the fumes since the combustion products might be harmful to your health. These byproducts include bromine, hydrogen bromide, nitrogen oxides,and carbon monoxide.

    9. Stability and reactivity

    Avoid exposing 6-Bromopurineto oxidizing agents, heat, or flames since it might lead to chemical decomposition.

    10. Chemical disposal

    Abide by the federal, state, and local laws when disposing of 6-Bromopurine. You can work with your local authority to help you with the disposal.

    11. Shipping Info

    6-Bromopurine is non-hazardous for any mode of transport

    Regulatory Information

    6-Bromopurine has no known CAS number exceeding the threshold level set by SARA Title III sections 302 and 313. Be sure to follow the regulations offered by your local authority.

    6-Bromopurine (767-69-1) Bulk Ordering and Pricing

    Whether you need large or small quantities of this product for your development, manufacturing or research applications, Apicmo, is your best partner. Just contact our friendly and professional  customer care team for a free, no-obligation quote.

    Bibliography

    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem, 6-Bromopurine, Sections 1-10.
    2. EA Veliz, PA Beal – The Journal of organic chemistry, 2001
    3. Eduardo A. Véliz*, and Peter A. Beal* Org. Chem.200166(25), pp 8592–8598.

  2. Apicmo

    The best 6-Bromopurine acid and service i have ever had,Nice experience

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