4,6-Dichloropyrimidine-2,5-diamine (55583-59-0)

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Description

4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) video

4,6-Dichloropyrimidine-2,5-diamine is a common pyridine compounds, pyridine compounds as the chemical industry, especially the fine chemical material, the application of a wide range of pharmaceutical intermediates, pharmaceutical products, pesticides, pesticide intermediates, feed and feed raw materials and many other fields. 4,6-Dichloropyrimidine-2,5-diamine is a very good pharmaceutical intermediates.

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4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Specifications

CAS 55583-59-0
CAS Min % 95.0
CAS Max % 100.0
MDL Number MFCD00792652
InChI Key ZXWGHENZKVQKPX-UHFFFAOYSA-N
Chemical Name or Material 4,6-Dichloropyrimidine-2,5-diamine
Physical Form Powder or Chunks
Packaging Glass bottle
Molecular Formula C4H4Cl2N4
Molecular Weight (g/mol) 179.009
Color White Powder
Melting Point 395.8 °C at 760 mmHg
Assay 98%

APICMO hazard icons

4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Safety and Handling

(55583-59-0) Hazard description:

  • Causes skin irritation [Warning Skin corrosion/irritation]
  • Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

4,6-Dichloropyrimidine-2,5-diamine Precautionary statement:

  • Do not touch the skin directly, it will cause skin irritation and corrode the skin.
  • IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Articles

Process for preparing 2,5-diamino-4,6-dichloropyrimidine

A process for the preparation of 2,5-diamino-4,6-dichloropyrimidine, which process comprises the chlorination of 2,5-diamino-4,6-dihydroxypyrimidine…

Beecham Group p.l.c. – US5216161, 1993, A

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1 review for 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0)

  1. APICMO

    Shopping for chemical products can be a bit hectic, the buying process can even be more tedious if you are not dealing with the right company. At APICMO we not only make your buying process smooth but also guarantee you value for your money. We are a leading chemical products manufacturing company that produces 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) among other chemical products. All our chemical products conform to the Common Good Manufacturing Practice (CGMP) and other manufacturing regulations. Buy from us today and experience exceptional service.

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Chemical Structure

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) -APICMO

     4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Synthesis Route

     4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Precursor and Downstream products

    Precursor

    Downstream Products

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Synonyms

    • 2,Me5-Diamino-4,6-dichloropyrimidine
    • 55583-59-0
    • 4,6-Dichloropyrimidine-2,5-diamine
    • 2,5-Diamino-4,6-dichloro-pyrimidine
    • Dichloropyrimidine-2,5-diamine
    • 2,5-Pyrimidinediamine,4,6-dichloro
    • MFCD00792652
    • NSC176971
    • ACMC-209Inu

     4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Product Specifications

    Purity 95-98%
    Physical State Powder or in chunks
    Monoisotopic Mass 177.981 g/mol
    Molecular Weight g/mol 179.004 g/mol
    Molecular Formula C4H4Cl2N4
    Melting Point˚c 395.8 at 760mmHg
    IUPAC Name 4,6-dichloropyrimidine-2,5-diamine
    Density 1.715g/cm^3
    Chemical Name 2,5-Diamino-4,6-dichloropyrimidine
    Boiling Point˚c 395.8 at 760mmHg
    CAS no 55583-59-0
    Solubility Slightly soluble to hot Methanol
    Flash Point˚c 193.2

     4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Physical and Chemical Properties

    APPEARANCE

    It is a white powder that could also be in chunk form.

    BONDING

    Hydrogen Bond Donor-2

    Acceptor-4

    Rotatable Bond 0
    Covalent Bond 1

     STABILITY

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) is stable under normal conditions. It, however, decomposes under high temperatures to produce;

    • Carbon monoxide
    • Carbon dioxide
    • Nitrogen oxides (NOx)
    • Hydrogen Chloride

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Uses

    • It is a building blockin chemical synthesis.
    • It is an essential pharmaceutical intermediate.
    • It is an essential reagent in the preparation of hexopyranosenucleosides, Abacavir impurities and carbocyclic.

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Computed Properties

    PROPERTY NAME PROPERTY VALUE
    Isotope Atom Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Heavy Atom count 10
    Formal Charge 0
    Compound Is Canonicalized True
    XLogP3-AA 1.1
    Exact Mass 177.981 g/mol
    Topological Polar Surface Area 77.8 A^2
    CACTVS Substructure Key Fingerprint AAADcYBjgAAGAAAAAAAAAAAAAAAAAA
    AAAAAsAAAAAAAAAAABgAAADAIQAAAA
    CAoBEiAB0JZIEACgAARgZACAgCkBFKAB
    ECAVhCASABASEAUBAgIAAJAACAAAAAAA
    AAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
    Complexity 110

    Hazards associated with 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0)APICMO hazard icons

    • It causes skin irritation once in contact with the skin. Its symptoms could be; skin rash, skin redness, itching /burning, scaling/crusting.
    • It causes severe eye damage/irritation once it gets to your eyes.Its signs include redness, burning pain, blurred vision, watering
    • It is poisonous once ingested. Its symptoms could be nausea or vomiting, stomach discomfort, fever and loss of appetite.
    • It irritates the respiratory system once inhaled. Its symptoms could be; Difficulty while breathing or shortness of breath, chest tightness and dry/ wet cough.

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Safety Measures

    1. Personal Protection

    Always wear the following protective gear;

    Respiratory protection

    To prevent respiratory irritation, use type P1 (EU EN 143) or type P95 (US) particle respirator. If you need higher level protection from the same, use type ABEK-P2 (EU EN 143) or type OV/AG/P99 (US) respirator cartridges.

    Ensure that you usetested and approved respirators and components  under proper governments standards such as NIOSH (US) or CEN (EU)

    Body Protection

    Wear impervious clothing for protection. You could also wear protective boots if it is necessary. The amount and concentration of the hazardous chemical at your workplace determine the type of protective garment that you wear.

    Skin Protection

    Use gloves while handling this chemical. You should always inspect gloves before using them to prevent the substance from permeating to your skin. Use gloves that are of high quality. Use an appropriate glove removal technique to ensure that you do not touch the outer surface to prevent contamination. Always dispose of gloves after using them in accordance with proper hygiene practice and regulations. Wash your hands and dry them when done.

    Face/Eye Protection

    Put on safety glasses that have side-shields that comply with EN 166. Ensure that you use tested and approved equipment by proper government standards such as EN 166 (EU) and NIOSH (US).

    2. 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Engineering Controls

    • Install a local exhaust or a closed system to protect the workers from being directly exposed to the dust, vapor, fumes produced in the workplace.
    • Install eye baths and safety showers where workers can flush their bodies /eyes and clean their protective garments in case of a spill. Thesafety showers are also crucial for putting out the fire on their clothes in the event of an accident.

    3. First Aid Measures

    SKIN CONTACT

    In case it gets in contact with your skin, take off all contaminated clothing immediately. Gently clean yourself with mild soap and plenty of water. If skin irritation or rashes persist, seek the advice of a doctor.

    EYE CONTACT

    If it splashes to your eyes, rinse cautiously with a lot of water for about 15 minutes. Take off contact lenses if you are wearing any and if it is safe to do so. Continue flushing with water and if irritation persists, see a doctor.

    INHALATION

    Take the victim to a place that has fresh air and make them lie in a rest position that allows them to breathe comfortably. If they are not breathing, give them artificial respiration. Get the attention of a doctor.

    INGESTION

    Rinse your mouth with water. If attending to an unconscious victim, do not give anything through the mouth. Get medical attention.

    A first aider should always wear personal protective equipment,i.e., rubber gloves and airtight gloves.

    4. When Using 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0)

    Ensure that you follow all safety regulations. Wear all the personal protective equipment that is required. Avoid breathing dust, fumes, mist to prevent irritation. Do not consume anything or smoke when using this chemical. Make sure that all containers that you are using are well-labeled. There should be proper ventilation in your working area. Make sure that you are close to safety showers, first aid equipment, spillage equipment and eye baths for fast response to an accident.

    5. After Using 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0)

    After you are done using the chemical, dispose of all the containers properly. Clean the work surface to ensure no spills left on it. Remove the protective gear you are in, clean it and give it ample time to ventilate. Clean your hands carefully and dry them.

    6. When out of use

    Label all the containers properly for identification and to prevent placing them near incompatible substances. Place the chemical in an area that has sufficient security to restrict access to anyone who is untrained and unauthorized to handle the chemicals as it would lead to accidents. Ensure that you place the chemical in a cool, dry area that has sufficient ventilation. The container should be tightly locked. You should not put the substance near sources of ignition to avoid combustion.

    7. 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Handling and Storage

    HANDLING

    While handling this chemical avoid the formation of aerosols and dust as they would be an irritant. Avoid the substance from getting into contact with your eyes or skin. Ensure that there is proper ventilation in the places where dust is formed to prevent its accumulation. Do not allow the substance to get into drains as it is a contaminant. Follow all good hygiene and safety practices including washing your hands before taking a break, visiting the lavatory and at the end of every workday. Ensure that you have first aid equipment close to you for fast response in the event of an accident. Avoid spilling the chemical as it may react with other substances or come into contact with your body.

    STORAGE

    Store the substance in a cool place. Keep the container tightly sealed and placed in a well-ventilated area. Store the chemical under inert gas to prevent absorption of moisture. You could also store it in a desiccator. Store it far from incompatible substances and ignition sources because it is flammable.

    8. 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Accidental Measures

    FIRE CONTROL

    In the event of a fire, work should be done from the windward using either of the following extinguishing media;

    • Dry chemical
    • Carbon dioxide
    • Alcohol-resistant foam
    • Water spray

    The chemical may decompose upon combustion to emit toxic fumes. You are therefore advised to wear breathing equipment that is self-contained if necessary. People who are uninvolved should evacuate to a safe place,and in case the fire extends to the surroundings, remove all containers that are movable if it is safe and easy to do so.

    SPILLING

    In case spillage occurs, keep people away from the leak. You should control the entry of uninvolved persons to the leakage area. Pick up the substance carefully without creating any dust. Sweep it up and scoop it, transfer it into an airtight disposal container and close it ready for discarding. Ensure that the substance doesn’t get into drains.

    9. Sensitivity and Reactivity

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) reacts with moisture. It is incompatible with;

    • Acids
    • Acid Chlorides
    • Acids anhydrides
    • Oxidizing agents

    It decomposes to produce; Hydrogen chloride gas, nitrogen oxides and carbon dioxide.

    10. Chemical Disposal

    You may mix the substance with a combustible solvent and burn it in an incinerator that has a scrubber and an afterburner but be very cautious while igniting because this chemical is highly flammable. You can give surplus and non-recyclable solutions to a disposal company that is licensed. Contact a waste disposal company that is authorized to dispose of the waste material for you. You can also recycle to process if it is possible.

    Dispose of any contaminated packaging as an unused product.

    Comply with all state, area, federal laws while disposing of this substance.

    11. Shipping Information

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) is safe to transport byboth air and by road.

    4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) Bulk Pricing and Ordering

    Do you need 4,6-Dichloropyrimidine-2,5-diamine (55583-59-0) for your manufacturing, development or research applications? Contact us now for any inquiries that you may have.

    BIBLIOGRAPHY

    1. Amines: Synthesis, Properties,and Applications, By Stephen .A. Lawrence, Page 161-167
    2. Chem Sources USA, Directories Publishing Company, Incorporated, 2004, the University of Michigan,4thFeb 2011,Page 425
    3. Genium’s Handbook of Safety, Health, and Environmental Data for Common Hazardous Substances: Index, Volume 3, By McGraw-Hill, 1999, Page 565

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