2,5,6-Trichloronicotinic acid (54718-39-7)

(2 customer reviews)

This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of 2,5,6-Trichloronicotinic acid (54718-39-7) with quality control system under CGMP manufacturing



2,5,6-Trichloronicotinic acid (54718-39-7) video

54718-39-7 Product Specifications

Boiling point (˚C) 359.1
Canonical SMILES C1=C(C(=NC(=C1Cl)Cl)Cl)C(=O)O
CAS no. 54718-39-7
Chemical name 2,5,6-Trichloronicotinic Acid
Density (g/cm3) 1.728
Empirical formula C6H2Cl3NO2
Flash point (˚C) 171
Formula weight (g/mol) 226.44
IUPAC name 2,5,6-Trichloropyridine-3-carboxylic acid
Melting point(˚C) 154 – 155
Monoisotopic mass (g/mol) 224.915
Physical State Solid
Purity 98%
Synonyms · 2,5,6-trichloropyridine-3-carboxylic acid
· 3-Pyridinecarboxylic acid, 2,5,6-trichloro-
· 2,5,6-Trichloropyridine-3-carboxylic acid
· 2,5,6-trichlornicotinsaeure



2 reviews for 2,5,6-Trichloronicotinic acid (54718-39-7)


    We manufacture and synthesize good quality 2,5,6-Trichloronicotinic Acid (54718-39-7) in large quantities. This product is subject to APICMO contract and is strictly for use in research, manufacturing, and development. We make sure to conform to the cGMP manufacturing standards in our productions.

    The molecular structure of 2,5,6-Trichloronicotinic Acid (54718-39-7):

    2,5,6-Trichloronicotinic acid powder (54718-39-7) -APICMO

    About 2,5,6-Trichloronicotinic Acid (54718-39-7)

    This product is an organic chemical under the class of pyridines. It is a white solid whose name is synonymous to 2,5,6-trichloro-3-pyridinecarboxylic acid, 2,5,6-trichloropyridine-3-carboxylic acid, and 3-pyridinecarboxylic acid, 2,5,6-trichloro-.

    The preparation of 2,5,6-Trichloronicotinic Acid (54718-39-7) involves the reaction of 2,5,6-trichloro-3-chloromethylpyridine and 2,6-dichloro-3-chloromethylpyridine with concentrated nitric acid. This process occurs in the presence of undiluted sulfuric acid and a catalyst, preferably a metal salt. The main advantage of this method is that it isboth economical and straightforward. It guarantees not only high yields but also minimal to no side-reactions. The reaction temperatures are low too.

    Application and Uses of 2,5,6-Trichloronicotinic Acid

    It is a primary intermediate and raw material used in the pharmaceuticals and organic synthesis.

    Physical & Chemical properties of 2,5,6-Trichloronicotinic Acid

    54718-39-7 bonding

    Covalent 1 unit
    Hydrogen bond Donor count – 1

    Acceptor count – 3

    Free rotatable bond 1

    The appearance of 2,5,6-Trichloronicotinic Acid

    It is off-white to yellow powder

    Computed Properties of 2,5,6-Trichloronicotinic Acid (54718-39-7)

    Property Name Property value
    XLogP3-AA 2.9
    Undefined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Topological polar surface area 50.2 A^2
    Surface tension (dyne/cm) 64.3
    Refractive index 1.618
    Isotope Atom Count 0
    Heavy Atom Count 12
    Formal Charge 0
    Exact Mass (g/mol) 224.915
    Enthalpy of vaporization (kJ/mol) 63.8
    Defined Bond Stereocenter Count 0
    Defined Atom StereocenterCount 0
    Compound is Canonicalized True
    Complexity 190

    2,5,6-Trichloronicotinic Acid (54718-39-7) Synthesis Route

    2,5,6-Trichloronicotinic acid (54718-39-7)

    Downstream Products and Precursors of 2,5,6-Trichloronicotinic Acid (54718-39-7)


    2,5,6-Trichloronicotinic acid (54718-39-7)

    Downstream product

    2,5,6-Trichloronicotinic acid (54718-39-7)

    2,5,6-Trichloronicotinic Acid Hazard Description and GHS ClassificationAPICMO hazard icons

    The Globally Harmonized System (GHS) has labeled2,5,6-Trichloronicotinic Acid (54718-39-7) as an irritant with a warning signal.

    This product is undoubtedly harmful when swallowed and will possibly lead to acute toxicity. When it gets in contact with the eye or skin, 2,5,6-Trichloronicotinic Acid causes mild to severe allergic reactions and permanent damages. Upon inhalation, it triggers inflammation of the respiratory tract with possibilities of breathing difficulties.

    2,5,6-Trichloronicotinic Acid (54718-39-7) Precautionary Statements and Safety Measures

    Handling 2,5,6-Trichloronicotinic Acid

    Do not use 2,5,6-Trichloronicotinic Acid (54718-39-7) for prolonged periods. Here are a few tips on safe management of the product.

    Precautionary statements

    These measures are in compliance with the precautionary codes P260, P261, P270, and P271.Avoid inhaling 2,5,6-Trichloronicotinic Acid, its fumes, vapors, gas, spray, or the related emissions. Observe all the laboratory precautions such as not drinking, or eating while the product is in use. Lastly, only work outdoors or in a ventilated room.

    Personal protective equipment

    Protection gears are always a priority. Whichever apparatus used should be tested, approved, and recommendedby the relevant state standards like EN 166 or NIOSH, for EU and US nationals, respectively. Among the safety equipment the user must wear, face shields, safety goggles, a respirator, chemical-resistant gloves, and impervious boots should be among them.

    Knowledge expertise

    Anyone working with 2,5,6-Trichloronicotinic Acid (54718-39-7) ought to have prior knowledge of the product, its hazards, precautionary measures, and the regulations governing its usage.If inexperienced, at least seek the counsel of an expert.

    Engineering Controls

    Use 2,5,6-Trichloronicotinic Acid only in a fume chamber. Other essentials to pre-install in your laboratory include air cleaning devices,exhaust ventilation, safety showers, eye bath, and fire extinguishing media.

    Storage of 2,5,6-Trichloronicotinic Acid (54718-39-7)

    Regulated Conditions

    Keep the product in a cool but dry place. There is no specific temperature, but anything below -20°C is okay.

    Precautionary statements

    In reference to the P-codes P233, P403, and P405, lock up2,5,6-Trichloronicotinic Acid (54718-39-7) in a securely sealed container. Ensure the storage area receives enough ventilation.

    After Use

    Observe the GHS P-codes P264, P362, and P363. Immediately after using 2,5,6-Trichloronicotinic Acid,bathe the hands thoroughly and take off the stained clothing.Launder the clothes before you even think of reusing them.

    Clean spillages, wash and ventilate the working bench. Dispose of all contaminated products, used gloves, and the empty chemical vessels.Any surplus 2,5,6-Trichloronicotinic Acid should be returned to the primary storage.

    First Aid Measures


    Relocate the victim from the point of exposure to a well-aerated space.Ensure the person rests in a proper breathing position. Check for shortness of breath, wheezing, breathing difficulties, and unconsciousness. In such a situation, give oxygen support or any recommendedartificial respiration.

    As per the guidelines listed in GHS P304 and P340, seek immediate attention from a medical expert when you continue feeling uncomfortable.


    Give the casualty some water or milk to take. The right amount should be between 2 to 4 cups. Another alternative is to thoroughly rinse the mouth with generous amounts of water to prevent oral toxicity.

    Never try to force vomit or administer anything orally to an unconscious person. In case you fail to manage the symptoms, or you continue to feel unwell, visit a physician with a copy of this MSDS, the label, or product container.

    Body contact

    When 2,5,6-Trichloronicotinic Acid (54718-39-7) makes contact with the eyes, use plenty of water to wash them. Keep the eyes open throughout the exercise and pay attention to the eyelids.

    When the chemical splashes on the skin, bathe with a lot of running water and soap, then use an emollient to cover the spot. If the reaction becomes uncontrollable, contact a physician for proper medical advice.

    Firefighting Measures

    Quench the fire using water spray, a polymer or alcohol-resistant foam,dry chemical powder, and CO2 gas. Put on self-contained breathing apparatus and other approved gears since the product emits toxic combustion fumes and gases, including hydrogen chloride, carbon monoxide, and carbon dioxide.

    Accidental Release Measures

    Control any leakages if safe and possible to do so. Do not let the spills enter drains. Use vermiculite, sand, or any other inert absorbent to pick up the spillages. Collect the residues in a closed vessel for disposal.

    2,5,6-Trichloronicotinic Acid (54718-39-7) Stability & Reactivity

    This product is incompatible with concentrated acids, bases, heat, and strong oxidants. Exposure to these substances may lead to a chemical reaction and evolution of oxides of carbon and nitrogen, and hydrogen chloride compound.

    2,5,6-Trichloronicotinic Acid Waste Disposal

    If you own a chemical incinerator, dissolve 2,5,6-Trichloronicotinic Acid (54718-39-7) in a combustible solvent and burn it down. A kiln fitted with a scrubber and an afterburner is safe.

    You can also get in touch with a local regulatory authority thatwill help you locate a licensed disposal company. Treat and eliminate 2,5,6-Trichloronicotinic Acid as special waste.

    54718-39-7Shipping Info

    It is non-hazardous for ground, air, and marine transport.

    Regulatory Information

    Adhere to all the international, state, federal, and local laws while using 2,5,6-Trichloronicotinic Acid (54718-39-7). This material safety data sheet (MSDS) is only a basis for safe handling and not a warranty for proper usage.

    There is no substance in this product exceeding the maximum occupational exposure values and SARA’s reporting requirements.

    Technical Details

    Our scientists excel in all areas, which call for scientific research, chemical analysis, analytical chemistry,synthesis, chromatography, material and life sciences, and the relateddisciplines.

    2,5,6-Trichloronicotinic Acid (54718-39-7) Bulk Ordering and Pricing

    We dispatch 2,5,6-Trichloronicotinic Acid (54718-39-7) either in small or large quantities. If you are in need of the product, feel free to place an order through our dedicated customer service. For the non-registered users, the display reflects the list price. However, you can create an account, sign in, and view the standard quotation.


    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem,2,5,6-Trichloronicotinic Acid , Sections 1-10.
    2. George Richard Newkome, Lucjan Strękowski, Piotr Tomasik, Zbigniew Ratajewicz, Interscience Publishers, Pyridine and Its Derivatives, Volume 14, Part 4, page 3-7.
    3. Fred W. McLafferty, Douglas B. Stauffer Wiley, 1991,  Mass spectrometry, The Important Peak Index of the Registry of Mass Spectral Data, Volume 3, page 34-36.
  2. Apicmo

    The best 2,5,6-Trichloronicotinic acid and service i have ever had,Nice experience

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