3-Aminopyrazine-2-carboxylic acid (5424-01-1)

3-Aminopyrazine-2-carboxylic acid (5424-01-1)

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SKU: 767-69-1-1-3 Category:

Description

3-Aminopyrazine-2-carboxylic acid (5424-01-1) Description

3-Aminopyrazine-2-carboxylic acid is an intermediate typically in the synthesis of 3-Aminopyrazine-2-carboxylic acid commercially named Favipiravir, which is a unique viral RNA Polymerase inhibitor for the treatment of Influenza (potentially treat the novel coronavirus pneumonia), acting on viral genetic copying to prevent its reproduction. A practical and step-economic route to Favipiravir. The complete synthesis of favipiravir from 2-aminopyrazine.

Favipiravir was approved for marketing in Japan in March 2014 and used for antiviral treatment of influenza A and B. In addition to the influenza virus, the drug also showed good antiviral activity to a variety of RNA viruses, such as Ebola virus, sand virus, Bunia virus, rabies virus, etc. Novel coronavirus pneumonia is inhibited by the latest research

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3-Aminopyrazine-2-carboxylic acid (5424-01-1) Specifications

CAS 5424-01-1
MDL Number MFCD00006141
InChI Key ZAGZIOYVEIDDJA-UHFFFAOYSA-N
Chemical Name or Material 3-amino-pyrazine-2-carboxylic acid;

3-Aminopyrazinoic acid;

3-AMINOPIPERAZINE-2-CARBOXYLIC ACID;

3-Aminopyrazine-2-ca;

3-amino-2-carboxy-pyrazine;

3-amino-2-pyrazine carboxylic acid;

2-Pyrazinecarboxylic acid,3-amino;

2-Amino-3-pyrazinecarboxylic Acid;

3-Aminophrazine-2-carboxylic acid;

2-aminopyrazine-3-carboxylic acid;
Infrared Spectrum Authentic
Physical Form Powder
Packaging Aluminum Foil Bag
Molecular Formula C5H5N3O2
Molecular Weight (g/mol) 139.1
Exact Mass 139.03800
SMILES C1=CN=C(C(=N1)C(=O)O)N
Color White to Amber powder to crystalline powder
Density 1.5±0.1 g/cm3
Melting Point 205-210 °C (dec.) (lit.)
Boiling Point 401.00 to  402.00 °C. @ 760.00 mm Hg (est)
Flash Point 386.00 °F. TCC ( 196.50 °C. ) (est)
Assay 98%
Solubility Soluble in Dimethyl Sulfoxide and Methanol
Vapour Pressure 0.0±1.0 mmHg at 25°C
Storage Store at -20° C

 

Safety and Handling

GHS H Statement

  • H315: Causes skin irritation.
  • H319: Causes serious eye irritation.
  • H335: May cause respiratory irritation.

GHS P Statement

  • P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280: Wear protective gloves/protective clothing/eye protection/face protection.
  • P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
  • P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

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