3-Aminopyrazine-2-carboxylic acid (5424-01-1)
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3-Aminopyrazine-2-carboxylic acid (5424-01-1) Description
3-Aminopyrazine-2-carboxylic acid is an intermediate typically in the synthesis of 3-Aminopyrazine-2-carboxylic acid commercially named Favipiravir, which is a unique viral RNA Polymerase inhibitor for the treatment of Influenza (potentially treat the novel coronavirus pneumonia), acting on viral genetic copying to prevent its reproduction. A practical and step-economic route to Favipiravir. The complete synthesis of favipiravir from 2-aminopyrazine.
Favipiravir was approved for marketing in Japan in March 2014 and used for antiviral treatment of influenza A and B. In addition to the influenza virus, the drug also showed good antiviral activity to a variety of RNA viruses, such as Ebola virus, sand virus, Bunia virus, rabies virus, etc. Novel coronavirus pneumonia is inhibited by the latest research
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3-Aminopyrazine-2-carboxylic acid (5424-01-1) Specifications
|Chemical Name or Material||3-amino-pyrazine-2-carboxylic acid; |
3-amino-2-pyrazine carboxylic acid;
|Packaging||Aluminum Foil Bag|
|Molecular Weight (g/mol)||139.1|
|Color||White to Amber powder to crystalline powder|
|Melting Point||205-210 °C (dec.) (lit.)|
|Boiling Point||401.00 to 402.00 °C. @ 760.00 mm Hg (est)|
|Flash Point||386.00 °F. TCC ( 196.50 °C. ) (est)|
|Solubility||Soluble in Dimethyl Sulfoxide and Methanol|
|Vapour Pressure||0.0±1.0 mmHg at 25°C|
|Storage||Store at -20° C|
Safety and Handling
GHS H Statement
- H315: Causes skin irritation.
- H319: Causes serious eye irritation.
- H335: May cause respiratory irritation.
GHS P Statement
- P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
- P280: Wear protective gloves/protective clothing/eye protection/face protection.
- P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
- P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
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