Description

The infection by the human papillomavirus (HPV) is the origin of several cancers around the world. In some areas of Brazil, cervical carcinoma is still the cancer with the highest incidence among women. After epithelial cell transformation by HPV, several molecular events are observed, resulting in the malignant phenotype. In this review we discuss potential molecular targets for therapeutic interventions in human HPV-related carcinomas, with emphasis on cervical cancer, based on the alterations observed in the signaling transduction pathways caused by HPV infection. With a special attention to tyrosine kinase receptors, and other kinases involved in signal transduction and angiogenesis, these pathological alterations are evaluated as novel targets for anticancer therapies in HPV-related carcinomas.

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4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (42754-96-1) Specifications

CAS	42754-96-1
CAS Min %	95%
CAS Max %	100%
MDL Number	MFCD09835493
InChI Key	CTYPROOLWJDUTA-UHFFFAOYSA-N
Chemical Name or Material	4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine
Infrared Spectrum	Authentic
Physical Form	Liquid
Packaging	Glass bottle
Molecular Formula	C5H2Cl2N4
Molecular Weight (g/mol)	189.005
SMILES	ClC1(=NC(Cl)=C2(C=NNC2(=N1)))
Color	Colorless through Yellow
Melting Point	140-149°C
Assay	98%

 

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (42754-96-1) Safety and Handling

• Do not breath dust or vapor.
• Have safety shower and eye wash available.
• Do not get in eyes, on skin or on clothing.
• Keep container tightly closed.
• Store in a cool, dry, well-ventilated place.
• Ensure adequate ventilation during use.
• Use only in a chemical fume hood.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (42754-96-1) Articles

Design, synthesis, anti-tumor activity, and molecular modeling of quinazoline and pyrido[2,3-d]pyrimidine derivatives targeting epidermal growth factor receptor

Three series of novel quinazoline and pyrido[2,3-d]pyrimidine derivatives were designed, synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase and a panel of five human cancer cell lines.

European Journal of Medicinal Chemistry 2016

Molecular targets for therapeutic interventions in human papillomavirus-related cancers (review)

The infection by the human papillomavirus (HPV) is the origin of several cancers around the world. In some areas of Brazil, cervical carcinoma is still the cancer with the highest incidence among women.

Oncology Reports 2010

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