4-Chloronicotinic acid (10177-29-4)

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The ability to produce, synthesize and manufacture large quantities of 4-Chloronicotinic acid (10177-29-4) with quality control system under CGMP manufacturing
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Description

4-Chloronicotinic acid (10177-29-4) video

At APICMO, we produce large measures of 4-Chloronicotinic Acid (10177-29-4) for use in research, development, and manufacturing. All our products are in line with the regulations of the current Good Manufacturing Practices.

The structural formula of 4-Chloronicotinic Acid (10177-29-4):

4-Chloronicotinic acid (10177-29-4)

About 4-Chloronicotinic Acid

This product is a significant building block whose intermediates are used in organic synthesis. It synthesizesheterocyclic analogues of Xanthine and also benzocanthinones via the radical induced cyclization of tributylin hydride.

4-Chloronicotinic Acid (10177-29-4) belongs to the same group as pyridines, carboxylic acids, chiral chemicals, and heterocyclic building blocks. The molecule is made up of six carbon atoms,four hydrogen atoms, two oxygen atoms, one nitrogen atom, and a chlorine atom. All these atoms add up to 14.

When determining the molecular weight (molar mass) of 4-Chloronicotinic Acid, we consider the total atomic weights of individual elementsmultiplied by the sum of the atoms.This weight is on the basis of each element’s atomic mass. The term is synonymous with molecular mass or relative molar mass. By definition, it is the dimensionless quantity expressed as the molar mass, and divided by constant 1g/mol.

Whereas molecular masses are evaluated from individual nuclide’s standard atomic weights, molar masses are computed from an element’s atomic mass. Atomic masses account for a compound’s isotopic distribution in a specified sample.

Uses and Applications of 4-Chloronicotinic Acid (10177-29-4)

The product is a useful intermediate in the synthesis of Xanthone’s heterocyclic analogues. The synthesis of benzocanthinones occurs through the radical induced cyclization of tributylin hydride.

10177-29-4 Product Specifications

Boiling point (˚C) 301.9
Canonical SMILES C1=CN=CC(=C1Cl)C(=O)O
CAS no. 10177-29-4
Chemical name 4-Chloronicotinic Acid
Density (g/cm3) 1.47
Empirical formula C6H4ClNO2
Flash point (˚C) 136.4
Formula weight (g/mol) 157.55
IUPAC name 4-chloropyridine-3-carboxylic acid
Melting point (˚C) 139 – 143
Monoisotopic mass (g/mol) 156.993
Physical State Solid
Purity 97%
Synonyms · 4-chloropyridine-3-carboxylic acid

· 3-carboxy-4-chloropyridine

· 4-chloro-nicotinic acid

· 3-pyridinecarboxylic acid, 4-chloro

Physical & Chemical Properties of 4-Chloronicotinic Acid (10177-29-4) 4-Chloronicotinic Acid (10177-29-4)

The solubility of 4-Chloronicotinic Acid

At 20°C, this product willdissolve in organic solvents.

Bonding

Covalent 1 unit
Hydrogen bond Donor count – 1

Acceptor count – 3

Free rotatable bond 1

Appearance

4-Chloronicotinic Acid (10177-29-4) is a white to pale yellow solid

4-Chloronicotinic Acid (10177-29-4) Computed Properties

Property Name Property value
XLogP3-AA 1
Vapor pressure (mmHg) 0.000454
Undefined Bond Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Topological polar surface area 50.19A^2
Surface tension (dyne/cm) 61
Refractive index 1.59
Isotope Atom Count 0
Heavy Atom Count 10
Formal Charge 0
Exact Mass (g/mol) 156.993
Enthalpy of vaporization (kJ/mol) 57.24
Defined Bond Stereocenter Count 0
Defined Atom Stereocenter Count 0
Compound is Canonicalized True
Complexity 140

4-Chloronicotinic Acid (10177-29-4) Recommended Synthesis Route

4-Chloronicotinic acid (10177-29-4)

4-Chloronicotinic acid (10177-29-4)

Downstream and Precursor Products of 4-Chloronicotinic Acid

Precursors

4-Chloronicotinic acid (10177-29-4)

Downstream products

4-Chloronicotinic acid (10177-29-4)

4-Chloronicotinic Acid GHS Hazard DescriptionAPICMO hazard icons

Bearing a warning signal, the 4-Chloronicotinic Acid (10177-29-4) is classed as an irritant with H-codes H302, H315, H319, and H335. The product causes mild to acute skin corrosion and inflammation of the respiratory system. To the eyes, the symptoms may end up being severe, leading to permanent damage. Additionally, 4-Chloronicotinic Acid is toxic if swallowed. The classification ratios of the hazards mentioned above are between 85% and 100%.

4-Chloronicotinic Acid (10177-29-4) Safety Measures and Precautionary Statements

Handling 4-Chloronicotinic Acid

Personal Protective Equipment

For the US users, wear a type N95 dust mask, eye shields, chemical-resistant gloves, and rubber footwear. For the European community, make sure to abide by the EN 166 regulations governing personal protection. Full-face protection prevents the user from breathing in dust, toxic gases, choking fumes, and other harmful emissions.

GHS Precautionary Statements

When using 4-Chloronicotinic Acid, refer to the precautionary codes P260 +P261 + P270 + P271. At no point should you breathe in any airborne irritants due to a possibility of respiratory toxicity. Use the product only in an outdoor setting or a room with sufficient ventilation. Observe the necessary lab precautions like not eating, drinking, or smoking while using chemicals.

Engineering Controls

The surest way of ventilating your workspace is to ensure your laboratory is equipped with some exhaust ventilation. A fume hood protects the user by wafting gases, vapors, and fumes away from the user and the source. Other things to put in place include a safety shower, an eye bath, and air cleaning devices.

Expertise

Only use 4-Chloronicotinic Acid (10177-29-4) if you have background knowledge of hazardous chemicals.If unsure, work under close supervision of an experienced user, who understands the dangers of the product.

After Using 4-Chloronicotinic Acid (10177-29-4)

Clear up the working bench and discard all residues in a labelled waste bag. Only store the unused product, which hasn’t been contaminated. Wash the hands thoroughly and clean all the soiled clothes before reusing.

Storage of 4-Chloronicotinic Acid (10177-29-4)

Keep 4-Chloronicotinic Acid under low controlled temperatures. Ideally, this ought to be in a freezer below -20°C. Keep it locked up in a secure place away from unauthorized access. Store the product in an airtight, labelled, and closed container. Ensure the area is dry, cold, and receives maximum aeration.

First Aid Measures

Inhalation

If you breathe in 4-Chloronicotinic Acid (10177-29-4) or its constituents, move away from the source to a place with fresh air. Either use oxygen support or any other artificial respiration in case there is shortness of breath, wheezing, or difficultiesin breathing.

Ingestion

On condition that there are no signs of unconsciousness, prepare about two to three cups of milk and water to give to the victim. Don’t administer anything that will induce vomiting.4-Chloronicotinic Acid (10177-29-4) is likely to be toxic to the digestive tract. Therefore, seek a better medical response to prevent further effects. Always carry this SDS and the chemical label as the reference.

Contact

Eye contact

If using contact lenses, take them off. Rinse the eyes with a lot of clean, cold, and running water. Do this for not less than 15 minutes while observing any changes. Seek advice from a doctor in case the symptoms persist.

Body Contact

Immediately 4-Chloronicotinic Acid (10177-29-4)4-Chloronicotinic Acid (10177-29-4) gains contact with the body, remove any clothing if possible. Use cold water and soap to bathe the area for 15 minutes. Cover the place with an emollient.

Firefighting Measures

Put out the blazing fire with a polymer or alcohol-resistant foam, dry chemical powder, carbon dioxide, or water spray. Avoid exposure to dangerous fumes and vapors by wearing a breathing apparatus, and protective gears.

Accidental Release Measures

Spillages

Most chemicals are accidentally released into the surroundings mainly through spills and leaks. Do not allow 4-Chloronicotinic Acid (10177-29-4) to find its way into water drains.

Scoop up the solid chunks or absorb the aqueous material using sand or vermiculite. Wash with enough water and ventilate the place. Collect everything in a tightly sealed container, ready for proper disposal.

Stability and Reactivity of 4-Chloronicotinic Acid (10177-29-4)

In the presence of heat, sparks, flames, moisture, strong oxidants,acids, and concentrated bases, 4-Chloronicotinic Acid (10177-29-4) readily decomposes into hazardous compounds. The decomposition products are carbon (IV) oxide, carbon (II) oxide, NOx, and hydrogen chloride.

4-Chloronicotinic Acid Chemical Waste Disposal

There are two recommended ways of eliminating 4-Chloronicotinic Acid (10177-29-4). You can either dispose of with the help of a local licensed disposal company or dissolve it in a flammable substance and burn in an incinerator.

Shipping Information

There are no special transportation requirementsprovided that the shipping conditions are normal. It is non-hazardous for all transport modes.

Regulatory Info

Stick to the regulations laid down by the relevant regulatory bodies when using this product.

Technical Details

Our researchers have in-depth knowledge in scientific fields involving thorough research, material and life sciences, chemical analysis, synthesis, chromatography, and many others.

4-Chloronicotinic Acid (10177-29-4) Bulk ordering and Pricing

Are you in need of 4-Chloronicotinic Acid in bulk or small measures? APICMO delivers pure quality products for all your research needs. Sign up for an account with us, log in, key in your quantity and view pricing. Contact our customer service for an order.

Bibliography

  1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem,4-Chloronicotinic Acid, Sections 1-10.
  2. A. Abramovitch, John Wiley & Sons, 15 Sep 2009, Pyridine and Its Derivatives, Supplement, Part 2, page 23-27.
  3. Erwin Klingsberg, John Wiley & Sons, 15 Sep 2009, Pyridine and Its Derivatives, Supplement, Part 3, page 20-22.
  4. Chemical Society (Great Britain), The Society, 1894, Journal of the Chemical Society, Volume 66, Part 1 page380-382.