2,4-Dichloro-5-(trifluoromethyl)pyrimidine (3932-97-6)

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The ability to produce, synthesize and manufacture large quantities of 2,4-Dichloro-5-(trifluoromethyl)pyrimidine (3932-97-6) with quality control system under CGMP manufacturing



5-Trifluoromethyl-uracil is obtained by chlorinating thymine under mild conditions, further chlorinating the resulting 2,4-dichloro-5-methyl-pyrimidine under drastic conditions to give 2,4-dichloro-5-trichloromethylpyrimidine, reacting the latter with a fluorinating agent to give 2,4-fluorinated and/or -chlorinated 5 trifluoromethylpyrimidines and subjecting these to hydrolysis. The novel chemical compounds 2,4-dichloro- 5-trichloromethylpyrimidine and 2,4-difluoro-5-trifluoromethylpyrimidine are obtained in the course of this process. Provided are 5-(trifluoromethyl)pyrimidine derivatives useful as intermediates for pharmaceuticals and agrochemicals and as intermediates for electronic materials and methods for producing the same. 2,4-dichloro-5-(trifluoromethyl)pyrimidine is reacted with 2,2,2-trifluoroethanol, benzyl alcohol, or benzenethiol to obtain the intended 2-(2,2,2-trifluoroethoxy)-4-chloro-5-(trifluoromethyl)pyrimidine, 2-benzyloxy-4-chloro-5-(trifluoromethyl)pyrimidine, 2,4-bis(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine, or 2-chloro-4-phenylthio-5-(trifluoromethyl)pyrimidine.

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2,4-Dichloro-5-(trifluoromethyl)pyrimidine (3932-97-6) Specifications

CAS 3932-97-6
CAS Min % 95.0
CAS Max % 100.0
MDL Number MFCD03426408
Chemical Name or Material 2,4-Dichloro-5-(trifluoromethyl)pyrimidine
Infrared Spectrum Authentic
Physical Form Clear colorless liquid
Packaging Glass bottle
Molecular Formula C5HCl2F3N2
Molecular Weight (g/mol) 216.98
SMILES C1=C(C(=NC(=N1)Cl)Cl)C(F)(F)F
Color Colorless to light brown
Melting Point N/A
Assay 97%


2,4-Dichloro-5-(trifluoromethyl)pyrimidine (3932-97-6) Safety and Handling

(3932-97-6) Hazard description:

APICMO hazard icons

◆Fatal if swallowed.

◆Causes skin irritation

◆Causes serious eye irritation

2,4-Dichloro-5-(trifluoromethyl)pyrimidine Precautionary statement:

◆Wash skin thoroughly after handling.
◆Do not eat, drink or smoke when using this product.
◆Wear protective gloves/ eye protection/ face protection.
◆IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician..
◆IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
◆Specific treatment (see supplemental first aid instructions on this label).
◆Rinse mouth.

◆If eye irritation persists: Get medical advice/ attention.

◆Store locked up.

◆Dispose of contents/ container to an approved waste disposal plant

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

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