2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)

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2,6-Di-tert-butyl-4-methylpyridine is used for the generation of enol triflates from ketones using trifluoromethanesulfonic anhydride. It is also used in the synthesis of 1,2-dihydro-2-silanaphthalene derivatives, as base in PtCl4-catalyzed cyclization reactions of homopropargyl azide derivatives and in diastereoselective synthesis of β-thiomannopyranosides.


Sparingly soluble in water. Soluble in ethanol, acetic acid and diethyl ether.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 – 8°C. Store under inert gas. It is sensitive to air and light.

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2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Specifications

CAS 38222-83-2
CAS Min % 95.0
CAS Max % 100.0
MDL Number MFCD00006305
Chemical Name or Material  2,6-Di-tert-butyl-4-methylpyridine
Infrared Spectrum Authentic
Physical Form Powder
Packaging Glass bottle
Molecular Formula C14H23N
Molecular Weight (g/mol) 205.345
Color White-Yellow
Assay ≥98.0% (GC,T)

2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Safety and HandlingAPICMO hazard icons

(38222-83-2) Hazard description:

  • Causes skin irritation.
  • Causes serious eye irritation.
  • May cause respiratory irritation.

2,6-Di-tert-butyl-4-methylpyridine Precautionary statement:

Avoid breathing dust/fume/gas/spray.

Wear protective gloves/protective clothing/eye protection/face protection.

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.

Store locked up.

Dispose of contents/container in accordance with local/regional/national/international regulations.


Recommended Storage : 2° to 8°C

The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Articles

Berberine type alkaloid production (by machine translation)

[Problem] to efficiently produce the alkaloid production-type alkaloid berberine berberine. 2, 6 – Di – tert – butyl -4 – methylpyridine [solution] trifluoromethanesulfonic anhydride with certain compound after the intramolecular cyclization reaction…

TSUMURA & CO 2010,

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