2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)

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2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) video

2,6-Di-tert-butyl-4-methylpyridine is used for the generation of enol triflates from ketones using trifluoromethanesulfonic anhydride. It is also used in the synthesis of 1,2-dihydro-2-silanaphthalene derivatives, as base in PtCl4-catalyzed cyclization reactions of homopropargyl azide derivatives and in diastereoselective synthesis of β-thiomannopyranosides.


Sparingly soluble in water. Soluble in ethanol, acetic acid and diethyl ether.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 – 8°C. Store under inert gas. It is sensitive to air and light.

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2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Specifications

CAS 38222-83-2
CAS Min % 95.0
CAS Max % 100.0
MDL Number MFCD00006305
Chemical Name or Material  2,6-Di-tert-butyl-4-methylpyridine
Infrared Spectrum Authentic
Physical Form Powder
Packaging Glass bottle
Molecular Formula C14H23N
Molecular Weight (g/mol) 205.345
Color White-Yellow
Assay ≥98.0% (GC,T)

2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Safety and HandlingAPICMO hazard icons

(38222-83-2) Hazard description:

  • Causes skin irritation.
  • Causes serious eye irritation.
  • May cause respiratory irritation.

2,6-Di-tert-butyl-4-methylpyridine Precautionary statement:

Avoid breathing dust/fume/gas/spray.

Wear protective gloves/protective clothing/eye protection/face protection.

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.

Store locked up.

Dispose of contents/container in accordance with local/regional/national/international regulations.


Recommended Storage : 2° to 8°C

The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Articles

Berberine type alkaloid production (by machine translation)

[Problem] to efficiently produce the alkaloid production-type alkaloid berberine berberine. 2, 6 – Di – tert – butyl -4 – methylpyridine [solution] trifluoromethanesulfonic anhydride with certain compound after the intramolecular cyclization reaction…

TSUMURA & CO 2010,

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Bulk Ordering & Pricing:

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2 reviews for 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)


    An in-depth introduction to 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)

    Are you seeking to buy any chemical product? Worry no more. We will certainly deliver.APICMO is a pharmaceutical company that has years of experience in chemical products synthesis including 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2). All our products abide by the Common Good Manufacturing Practice (CGMP) and other manufacturing regulations. We focus on producing high quality and cost-effective chemical products. Count on us to deliver products that meet your quality expectation on time and within your budget.

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Chemical Structure

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Synthesis Route

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Precursor and Downstream Products


    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)


    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Synonyms

    • 2,6-Di-tert-butyl-4-methylpyridine
    • 38222-83-2
    • 2,6-ditert-butyl-4-methylpyridine
    • 2,6-di-t-Butyl-4-methylpyridine
    • 2,6-ditert-butyl-4-methyl-pyridine
    • Pyridine,2,6-bis(1,1-dimethylelethyl)-4-meth
    • DTBMP
    • Di-tert-butyl-4-Methylpyr
    • Dibutylmethylpyridine
    • 4-Methyl-2,6-di-tert-butylpyridine

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Product Specifications

    Purity 98%
    Physical State Liquid or low melting solid
    Monoisotopic Mass 205.183
    Molecular Weight g/mol 205.345
    Molecular Formula C14H23N
    Melting Point ˚c 33-36
    IUPAC Name 2,6-ditert-butyl-4-methylpyridine
    Density 1.476 g/cm^3
    Chemical Name 2,6-ditert-butyl-4-methylpyridine
    Boiling Point ˚c 233
    CAS no 38222-83-2
    Solubility Sparingly soluble in water
    Soluble in diethyl ether, ethanol,and acetic acid
    Flash Point ˚c 83

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Physical and Chemical Properties


    It is a white, yellow liquid that slowly solidifies


    Hydrogen Bond Donor-0


    Rotatable Bond 2
    Covalent Bond 2


    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) is stable under normal conditions. Under high temperatures, it decomposes to Nitrogen oxides (NOx), Carbon dioxide/Carbon monoxide

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Uses

    • Used in diastereoselective production of beta-thiomannopyranosides
    • Used to generate enoltriflates from ketones using a trifluoromethanesulfonic anhydride
    • Used as a base in PtCl4-catalyzed cyclization reactions of homopropargylazide derivatives
    • Used in the manufacture of 1,2-dihydro-2-silanaphthalene derivatives.

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Computed Properties

    Isotope Atom Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Heavy Atom count 15
    Formal Charge 0
    Compound Is Canonicalized True
    XLogP3-AA 4.6
    Exact Mass 205.183
    Topological Polar Surface Area 12.9 A^2
    Complexity 184

    Hazards associated with 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)APICMO hazard icons

    • It may cause respiratory system irritation once inhaled. Symptoms for respiratory irritation are throat irritation, difficulty in breathing,headache,tiredness,dizziness, and tightness in the chest.
    • It is hazardous once ingested. Its symptoms may include vomiting, stomach pain/discomfort, nausea, redness and soreness of both the mouth and throat.
    • It irritates the eyes once it splashes into the eyes. It may cause eye redness, excessiveeye-watering, pain,and itchiness.
    • It leads to skin irritation once it comes into contact with the skin. Its symptoms are by skin redness, rashes and itching/burning.

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Safety Measures

    1. Personal Protection


    Ensure that you wear proper protective clothing and gloves to prevent your skin from getting into contact with the chemical product.Check the gloves before use for any tears that could allow the substance to penetrate. Make sure that you select gloves that are suitable for the operation that you are undertaking regarding user susceptibility, chemical compatibility and local conditions in which you’ll use the product,i.e., the possibility of having a cut. Use proper glove removal technique without touching the outer surface to avoid recontamination. You are advised to use glove type EN 374.


    Wear goggles that are of (European standard-EN 166) type.


    Use suitable certified respirators in case you are facing chemical product concentrations that are above the exposure limits. Ensure that all respiratory protective equipment is well fitting.

    For small scale use European standard EN 149:2001 or MSHA/NIOSH approved respirator. Use a particle filter: EN 143 half mask.

    For large scale use European Standard EN 136,or MSHA/NIOSH approved

    Ensure that you conduct a facepiece fit test before using any respiratory protective equipment.

    2. 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Engineering Controls

    • Install safety showers and eyewash stations in the workstation. They should be 10 seconds close to the working area to allow fast response to an accident.
    • Ensure that there is sufficient ventilation especially in areas where air supply is low. You can use local exhaust systems or fume hoods. The ventilation systems should be well maintained and well designed to remove contaminated air that could be a hazard.
    • Enclosure or isolation of the process to keep you out and the chemical product inside. You can use glove boxes, to protect yourself from hazardous gases produced.
    • Introduction of process controls to change the performance of operationstominimize release or contact,i.e., decrease the temperature used to reduce the amount of vapor produced.

    3. First aid measures


    In case one inhales the chemical product, remove them from the contaminated area and get them to a place that has fresh air. Let them lie down in a position that they can breathe comfortably. Give oxygen if their breathing is difficult and administer artificial respiration if they are not breathing. Consult a doctor.


    If it splashes into your eyes, rinse your eyes with plenty of water for a minimum of 15 minutes. Clean under the eyelids too. Ensure that you take off contact lenses if you were wearing any. Obtain medical attention.


    If ingested, do not induce vomiting. Take plenty of water. Do not try giving an unconscious victim anything through the mouth. Seek the attention of a doctor.


    Take off any contaminated clothing or shoes.Clean the skin surface immediately with a lot of water and mild soap. Call a doctor straight away. Speedy action is essential hence you are advised to get the attention of a doctor soonest possible.

    All first aiders should be in personal protective equipment and be aware of the materials involved.

    4. When using 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)

    Comply with all safety regulations and good hygiene practice. Wear the personal protective gear to protect yourself from exposure. Ensure that you have safety showers, eyewash stations, first aid and spillage equipment close to you to avoid a response delay in the event of an accident. Ensure that there is adequate ventilation in the working area to prevent the accumulation of dust and vapors. Avoid eating, drinking or smokinganything while using this chemical product. Ensure that all containers you are using are well-labeled including the appropriate hazard warnings.

    5. After using 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2)

    Take off the protective gear you are in after the operations. Clean them and allow them to ventilate before wearing them again. Clean your working surface to ensure that it is safe from any chemical spills. Wash your hands thoroughly even if you were in gloves. Dispose of all containers according to the regulations.

    6. When out of use

    Do not leave any chemical product in a location that they may fall off to avoid spillage. All chemical products bottles should be returned in the refrigerator immediately. Ensure that the containers are well-labeled and tightly sealed. Place them in a cool, dry place that is well ventilated. Do not place near any heat or ignition sources because it is flammable. Do not place near strong oxidizing agents and strong acids. Keep out of access from unauthorized or untrained personnel.

    7. 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Handling and storage


    Follow all the rules regarding the handling of chemical products. Avoid contact with the eyes and the skin. Do not breathe the dust, mist,andvapors produced. Keep away from any heat and ignition sources. Ensure that you use in a fume hood. Avoid the formation of dust and its spread in the air.Always wash your hands before taking breaks, visiting the washroom, consuming anything and at the end of a workday. Use running water and a clean towel to dry your hands to avoid recontamination. Ensure that there is enough ventilation and no chemical spills in the working area.


    Keep it refrigerated. The containers should be well-labeled and stored away from strong oxidizing agents and strong acids. The containers should also be tightly capped to avoid vapors from reacting with each other in the refrigerator. Store it in a cool area that is dry, and far from any ignition sources to avoid hazards.

    8. 2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Accidental measures


    Remove any sources of ignition that may be close. Keep uninvolved persons away from the scene. Transfer any portable containers to a safe place. Sweep the substance or vacuum it up and transfer it to an appropriate, closable waste container ready for disposal. Avoid any incompatible substances during the clean-up process.


    Use any of the following extinguishing media;

    • Chemical foam
    • Carbon dioxide
    • Water spray
    • Dry chemical

    Be extra cautious as the containers may explode upon heating.

    The is the emission of the following hazardous fumes upon combustion; Carbon dioxide, Carbon monoxide (CO), Nitrogen oxides (NOx). Firefighters are advised to wear full protective gear and a self-contained breathing apparatus pressure-demand that is approved by MSHA/NIOSH.

    9. Sensitivity and Reactivity

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) is sensitive with heat, light,and air. It reacts with strong acids and strong oxidizing agents.

    10. Chemical Disposal

    Transfer all the waste material into an appropriate waste disposal container and arrange for collection from a licensed disposal company. Empty containers may retain residue which can be hazardous,and you should, therefore,get rid of themappropriately.Keep the waste products and containers away from any ignition sources. You can also incinerate this product when in compliance with local laws.Do not dispose of the waste in a sewer. Ensure that you conform to all state, area and federal regulations.

    11. Shipping Information

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) is safe to transport by air, water,and road.

    2,6-Di-tert-butyl-4-methylpyridine (38222-83-2) Bulk Pricing and Ordering

    Please contact us in case if you have any inquiries or concerns. Thank you.


    1. Thermophysical Properties of Chemicals and Hydrocarbons, By Carl L. Yaws,page 270.
    2. Encyclopedia of Occupational Health and Safety: -Guides, indexes, directory,edited by Jeanne MagerStellman, page 219-240.
    3. Handbook of Reagents for Organic Synthesis- Reagents for Glycoside, Nucleotide, and Peptide Synthesis,Volume 7 of Handbook of Reagents for Organic Synthesis, David Crich, Wiley 2005, page 255.
  2. Apicmo

    The best 2,6-Di-tert-butyl-4-methylpyridine and service i have ever had,Nice experience

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