Description

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) Description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage.

Galactosidases are enzymes that breakdown GM1. GM1， also known as monosialotetrahexosylganglioside, it s the “prototype” ganglioside, is a member of the ganglio series of gangliosides which contain one sialic acid residue. GM1 has important physiological properties and impacts neuronal plasticity and repair mechanisms, and the release of neurotrophins in the brain. Besides its function in the physiology of the brain, GM1 acts as the site of binding for both cholera toxin and E. coli heat-labile enterotoxin (Traveller’s diarrhea).

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Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) Specifications

CAS	37758-47-7
CAS Min %	95%
CAS Max %	100%
MDL Number	MFCD00466936
InChI Key	QPJBWNIQKHGLAU-IQZHVAEDSA-N
Chemical Name or Material	Monosialotetrahexosylganglioside Sodium (Porcine brain),GM1
Infrared Spectrum	Authentic
Physical Form	powder
Packaging	/
Molecular Formula	C73H131N3O31
Molecular Weight (g/mol)	1546.841
SMILES	CCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO) OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4) CO)O)O)O)NC(=O)C)OC5(CC(C(C(O5)C(C(CO)O)O)NC(=O) C)O)C(=O)O)O)O)O)C(C=CCCCCCCCCCCCCC)O
Color	White or off-white
Melting Point	207-230ºC
Assay	98%

 

Testing items	In house Quality Standards
Chracter	White or white powder; slightly smelly, tasteless; wet. This product is soluble in water, very slightly dissolved in methanol, almost insoluble in anhydrous ethanol.
Identification
Color rendering reaction 1	Take the test solution 0.2ml under the content determination, add water 2ml, and then add the Hydroquinone hydrochloric acid solution (hydroquinone 0.2g, add water 10ml dissolved, add hydrochloric acid 90ml, add 0.1mol/L Copper sulfate solution 0.25ml, refrigerator Preservation) 2ml, water bath heating for 15 minutes, solution blue and purple, with N-e alcohol 5ml Vibration extraction, n-e alcohol layer is blue.
Color rendering reaction 2	Take this product about 20mg, add glacial acetic acid 1ml, hot water bath heating fully dissolved, add three ferric chloride test fluid 1 drops, in the hot water bath along the pipe wall slowly add sulfuric acid 1ml, so that the solution into two layers, the two-liquid interface should be brown
Sodium salt	The identify reaction of sodium salt in this product (Chinese Pharmacopoeia 2015 edition four 0301).
Liquid chromatography(LC)	In the chromatographic graph recorded under the content determination, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
Infrared spectroscopy	The infrared light absorption map of this product should be consistent with the map of the control product (Chinese Pharmacopoeia 2015 edition four 0402).
Inspect
PH	5.0～6.5
Clarity and color of solution	Should be clarified colorless; if it is cloudy, it shall not be thicker than the standard liquid of turbidity No. 1th; If the color rendering should not be deeper than the Yellow No. 1th colorimetric solution.
High Pressure determination	The finished solution should be clear and transparent after high temperature, no milk light, no precipitation
Sensitizing factor (Miscellaneous protein)	≤50000
Total Sialic acid	According to the dry product calculation, the saliva containing acid should be 19.0~21.0%
Related substances	Sialic acid ≤0.3%;GD3, GD1a, unknown impurities are ≤ 0.5%; impurities and ≤2.0%
Protein	≤1.0%
High molecular weight impurities	≤0.5%
Residual solvents	Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
Water	≤4.0%
Burning residue	≤5.0%
Heavy metal	≤20ppm
Abnormal toxicity	Comply Regulations
Antihypertensive substances	Should be in accordance with the regulations (multiple quantities of administration)
Pyrogen	Should be in accordance with the regulations (multiple quantities of administration)
Microbial limits	The total number of aerobic bacteria should be <100cfu/g, and the total number of molds and yeasts should be <50cfu/g
Specific	≥98.0%

 

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) Safety and Handling

GHS H Statement

• H318-H302-H335-H315
• Causes serious eye damage.
• Harmful if swallowed.
• May cause respiratory irritation.
• Causes skin irritation.

GHS P Statement

• P261-P280-P305+P351+P338-P304+P340-P405-P501a
• Avoid breathing dust/fume/gas/mist/vapors/spray.
• Wear protective gloves/protective clothing/eye protection/face protection.
• IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
• Store locked up.
• Dispose of contents/container in accordance with local/regional/national/international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Articles

Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain.

Biol. Chem. 288(36) , 25804-9, (2013)

Cholera toxin causes diarrheal disease by binding ganglioside GM1 on the apical membrane of polarized intestinal epithelial cells and trafficking retrograde through sorting endosomes, the trans-Golgi…

The Alzheimer’s disease amyloid-β peptide affects the size-dynamics of raft-mimicking Lo domains in GM1-containing lipid bilayers.

Staneva G, Puff N, Stanimirov S, Tochev T, Angelova MI, Seigneuret M.

Soft Matter. 2018 Dec 5;14(47):9609-9618. doi: 10.1039/c8sm01636d.PMID: 30457145

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