Description

Chloropyrimidine-5-carboxylic acid, also known as 2-chloro-pyrimidine carboxylic acid, is a common pyridine compound, and chloropyrimidine-5-carboxylic is a good pharmaceutical intermediate. But 2-pyrimidine carboxylic acid causes skin irritation, severe eye irritation and respiratory stimulation, so when you use it, you have to be careful.

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2-Chloropyrimidine-5-carboxylic acid (374068-01-6) Specifications

CAS	374068-01-6
CAS Min %	96.0
CAS Max %	100.0
MDL Number	MFCD06739036
InChI Key	DUCXUPKLVVSJKA-UHFFFAOYSA-N
Chemical Name or Material	2-Chloropyrimidine-5-carboxylic acid
Infrared Spectrum	Authentic
Assay Percent Range	97%
Physical Form	Powder or Crystalline Powder
Packaging	Glass bottle
Molecular Formula	C5H3ClN2O2
Molecular Weight (g/mol)	158.54
SMILES	C1=C(C=NC(=N1)Cl)C(=O)O
Color	Powder or Crystalline Powder
Chemical Name or Material	2-Acetylphenylboronic acid
Melting Point	125.0° to 127.5°C
Assay	97%

2-Chloropyrimidine-5-carboxylic acid (374068-01-6)Safety and Handling

(374068-01-6) Hazard description:

• May Causes skin irritation [Warning Skin corrosion/irritation]
• May Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

2-Chloropyrimidine-5-carboxylic acid Precautionary statement:

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

2-Chloropyrimidine-5-carboxylic acid (374068-01-6) Articles

A Convenient and Concise Metal-Free Approach to Functionalized Bicyclic Pyrimidinones from Oxazine-2,6-diones

The synthesis of previously unreported pyrazolo-pyrimidinones and isoxazolo-pyrimidinones are achieved via metal-free coupling of oxazine-2,6-diones with pyrazolidinone and isoxazolidinone, respectively. The synthesis provides easy access to a variety of novel 2-dimensional building blocks that can be derivatized to generate a range of drug- and agro-like molecules.

2018 vol. 50 # 10 p. 2087 – 2093

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