2-Chloropyrimidine-5-carboxylic acid (374068-01-6)

(2 customer reviews)

This product(s) resides on a APICMO contract.

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2-Chloropyrimidine-5-carboxylic acid (374068-01-6) video

Chloropyrimidine-5-carboxylic acid, also known as 2-chloro-pyrimidine carboxylic acid, is a common pyridine compound, and chloropyrimidine-5-carboxylic is a good pharmaceutical intermediate. But 2-pyrimidine carboxylic acid causes skin irritation, severe eye irritation and respiratory stimulation, so when you use it, you have to be careful.

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2-Chloropyrimidine-5-carboxylic acid (374068-01-6) Specifications

CAS 374068-01-6
CAS Min % 96.0
CAS Max % 100.0
MDL Number MFCD06739036
Chemical Name or Material 2-Chloropyrimidine-5-carboxylic acid
Infrared Spectrum Authentic
Assay Percent Range 97%
Physical Form Powder or Crystalline Powder
Packaging Glass bottle
Molecular Formula C5H3ClN2O2
Molecular Weight (g/mol) 158.54
Color Powder or Crystalline Powder
Chemical Name or Material 2-Acetylphenylboronic acid
Melting Point 125.0° to 127.5°C
Assay 97%

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2-Chloropyrimidine-5-carboxylic acid (374068-01-6)Safety and Handling

(374068-01-6) Hazard description:

  • May Causes skin irritation [Warning Skin corrosion/irritation]
  • May Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

2-Chloropyrimidine-5-carboxylic acid Precautionary statement:

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

2-Chloropyrimidine-5-carboxylic acid (374068-01-6) Articles

A Convenient and Concise Metal-Free Approach to Functionalized Bicyclic Pyrimidinones from Oxazine-2,6-diones

The synthesis of previously unreported pyrazolo-pyrimidinones and isoxazolo-pyrimidinones are achieved via metal-free coupling of oxazine-2,6-diones with pyrazolidinone and isoxazolidinone, respectively. The synthesis provides easy access to a variety of novel 2-dimensional building blocks that can be derivatized to generate a range of drug- and agro-like molecules.

2018 vol. 50 # 10 p. 2087 – 2093

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

2-Chloropyrimidine-5-carboxylic acid (374068-01-6) Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?


2 reviews for 2-Chloropyrimidine-5-carboxylic acid (374068-01-6)


    Could you be searching for a reliable chemical synthesizing company? Look no further. APICMO has proven its worth and incredible ability when it comes to the production of chemicals including 2-chloropyrimidine-5-carboxylic acid (374068-01-6) also referred to as 2-chloro-pyrimidine carboxylic acid. We can synthesize and produce it in large quantities, observing all the rules and regulations of CGMP and meeting the requirements of the quality control system.

    2-chloropyrimidine-5-carboxylic acid description

     (374068-01-6) chemical structure

    2-Chloropyrimidine-5-carboxylic acid (374068-01-6)

    2-chloropyrimidine-5-carboxylic acid (374068-01-6) product specification

    CAS NO 374068-01-6
    Chemical name 2-chloropyrimidine-5-carboxylic acid
    Density 1.58g/cm 3
    IUPAC name 2-chloropyrimidine-5-carboxylic acid
    Flashpoint(ºC ) 202.612
    Melting point 125.0° to 127.5°C
    Boiling point 411.407ºC at 760 mmHg
    Infrared Spectrum Authentic
    Molecular Formula C5H3ClN2O2
    Chemical Name or Materia 2-Acetylphenylboronic acid
    Physical Form Powder or Crystalline Powder
    Molecular Weight (g/mol) 158.54
    SMILES C1=C(C=NC(=N1)Cl)C(=O)O
    Synonyms Z1741971255
    2-chloropyrimidine-5-carboxylic acid,AldrichCPR
    2-chloropyrimidine-5-Carboxylic Acid
    2-Chloro-pyrimidine-5-carboxylic acid
    5-Pyrimidinecarboxylicacid, 2-chloro-

    2-chloropyrimidine-5-carboxylic acid (374068-01-6) chemical and physical properties

    This product is a crystalline powder

    Hydrogen bonding

    Rotatable bond count 1
    Hydrogen bond donor count 1
    Hydrogen bond acceptor count 4


    374068-01-6 computed properties

    Covalently-Bonded Unit Count 1
    Isotope Atom Count 0
    Defined Bond Stereocenter Count 0
    Undefined Bond Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Heavy Atom Count 10
    Formal Charge 0
    Compound Is Canonicalized True
    XLogP3-AA 0.7
    Monoisotopic Mass 157.988 g/mol
    Topological Polar Surface Area 63.1 A^2
    Complexity 134

    2-chloropyrimidine-5-carboxylic acid uses

    This product is used as a pharmaceutical intermediate

    Hazards associated with 2-chloropyrimidine-5-carboxylic acid

    GHS classification symbol

    APICMO hazard icons

    If it comes into contact with your skin, this chemical could result to;

    • Skin irritation and allergies which could end up into soreness, redness, and inflammation
    • Eye irritation once it comes into contact with your eyes. This problem could become permanent damage if not handled appropriately
    • It could result in irritation in the respiratory tract if inhaled
    • It leads to vomiting and diarrhea in the event of ingestion

    2-chloropyrimidine-5-carboxylic acid safety measures and personal protection

    When working with this chemical, you have to protect your body fully to ensure that it does not come into direct contact with your skin.

    Skin protection

    • Put on long-sleeved clothes to protect your hands
    • Wear heavy protective gloves
    • Ensure to put on the appropriate footwear


    • Put on protective glasses to ensure that the product does not come into contact with your eyes

    Respiratory protection

    • Ensure to put on a dust mask to ensure that you do not inhale the product’s dust or fumes
    • Choose a mask with air filters
    • Make sure that the mask covers the mouth area too to avoid accidental ingestion

    1. 2-chloropyrimidine-5-carboxylic acid (374068-01-6) engineering control

    Your working space should be well ventilated and well-equipped with the necessary safety devices and measures. These include fire extinguisher, fume hood, safety shower, taps with running water and air cleaning equipment.

    2. First aid measures

    When working with 2-chloropyrimidine-5-carboxylic acid, things could go wrong, and you could accidentally expose your body to the chemical. This comes in handy with some risks, and you, therefore, need to take immediate measures to put things under control. In such cases, administer the following first aid measures;

    skin contact

    Rush to the tap and rinse the affected area with a lot of water and non-abrasive soap. If your clothes got the spillage too, it is best if you take off the damaged clothes and put on clean ones

    Eye contact

    Rinse your eyes with running water for about 15 minutes. If irritation persists, do not hesitate to seek medical assistance.


    The victim should be taken outdoors or transferred to a well-ventilated room with lots of fresh air. If s/he is having breathing difficulties, administer artificial oxygen before rushing them to a healthcare center.


    In the event of accidental swallowing, the victim should rinse his/her mouth thoroughly with a lot of clean water. If s/he is unconscious, avoid administering anything through the mouth. Also, note that you should never induce vomiting.

    3. 2-chloropyrimidine-5-carboxylic acid storage

    • Ensure to store this chemical with its original container
    • Store it in a cool, dry place
    • The container should be tightly closed and ensure that there are no leaks
    • Lock it in a safe place away from any unauthorized access
    • Do not keep it near other products that could promote decomposition

    4. Precautions when using 2-chloropyrimidine-5-carboxylic acid

    When working with this chemical, you need to be extra cautious to avoid any accidents.

    • Do not inhale its fumes, mist or vapor
    • Ensure that your working area is adequately ventilated
    • Your laboratory should be equipped with safety and emergency equipment which include fire extinguisher, vapor compressor, fume hood, air cleaner, taps with running water and a safety shower

    5. After using 2-chloropyrimidine-5-carboxylic acid

    Safety measures do not end at using the chemical. You need to observe them even after you are done working by;

    • Cleaning the working area and get rid of any empty containers and residue. Make sure to dispose them following the rules and regulations of your state
    • Store the remaining product appropriately
    • Observe your hygiene by washing your hands first, take a shower, put on clean clothes and wash the clothes you had on when working

    6. 2-chloropyrimidine-5-carboxylic acid accidental cases


    If you accidentally spill the chemical, do not panic. Take an absorbent material and soak the spilled product. Toss it in a waste container. Wash the area with plenty of water and do not forget to ventilate air for adequate air movement. Use a vapor compressor to minimize its vapor and remember, your body should be well protected while doing this.

    7. Stability

    This chemical is very stable but only when used and stored under the appropriate pressure and temperature. Avoid using it with other chemicals that could cause decomposition, such as strong acids and oxidizing agents.

    8. 374068-01-6 waste disposal

    You should treat this product as special waste and therefore observe the local, federal and international rules and regulations when disposing it. Also, you can opt to burn it in an incinerator for further safety.

    9. Shipping details

    Based on the fact that the chemical is stable, it can be shipped in bulk without the fear of any dangers.

    2-chloropyrimidine-5-carboxylic acid regulatory information

    All the information provided in this article is correct as per our knowledge, and it was developed in compliance with European Union regulations. It is meant to be a guide for safety when handling and using the chemical.

    Always observe all your local and federal rules and regulations when using, storing and disposing the chemical.

    Technical information

    Our technicians are dedicated to offering the best of best chemicals. They excel in all areas concerning chemical research, synthesis, production, life science, material science, chemical analysis, and chromatography.

    2-chloropyrimidine-5-carboxylic acid bulk ordering and pricing

    Note that this product is meant for research, development, and manufacturing. If you require this chemical in bulk for any of these purposes, feel free to order with us.


    1. National Centre For Biotechnology Information, US. National Library Of Medicine, PubChem 2-chloropyrimidine-5-carboxylic acid (374068-01-6) Sections 1-10.
    2. H. Rodd, Elsevier Pub. Co., 1960 – Chemistry, Organic, Chemistry of Carbon Compounds: pt. A. Heterocyclic compounds. pt. B. Heterocyclic compounds. pt. C. Heterocyclic compounds. pt. E. Heterocyclic compounds, page 2136.
    3. H. Rodd, Elsevier Publishing Company, 1951, Carbon compounds, Chemistry of Carbon Compounds: pt. A General introduction and aliphatic compounds. pt. B. Aliphatic compounds, page 1293-1294.
  2. Apicmo

    The best 2-Chloropyrimidine-5-carboxylic acid and service i have ever had,Nice experience

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