This product(s) resides on a APICMO contract.
The ability to produce, synthesize and manufacture large quantities of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) with quality control system under CGMP manufacturing
3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) video
APICMO offers a wide range of products which includes 3-Amino-6-chloropyridine-2-carboxamide. It belongs to intermediates category. Contact us for more information.
3-Amino-6-chloropyridine-2-carboxamide should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire.
Store in closed vessels, refrigerated.
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3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Specifications
|CAS Min %||95%|
|CAS Max %||100%|
|Chemical Name or Material||3-Amino-6-chloropyridine-2-carboxamide|
|Molecular Weight (g/mol)||171.58|
3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Safety and Handling
(175358-01-7) GHS H Statement
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- Harmful if inhaled
- May cause respiratory irritation
- Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
- General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
- Engineering Controls: Use only in a chemical fume hood.
3-Amino-6-chloropyridine-2-carboxamide GHS P Statement
- Avoid breathing dust/fume/gas/mist/vapours/spray
- IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses if present andeasy to do – continue rinsing
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Articles
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer’s disease is the alignment of potency, drug-like properties, and selectivity over related aspartyl proteases such as Cathepsin D (CatD) and BACE2. The potential liabilities of inhibiting BACE2 chronically have only recently begun to emerge as BACE2 impacts the processing of the premelanosome protein (PMEL17) and disrupts melanosome morphology resulting in a depigmentation phenotype.
Journal of Medicinal Chemistry 2018 vol. 61 # 10 p. 4476 – 4504
Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors
An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and highly brain penetrant BACE1 inhibitor, was able to reduce significantly CSF Aβ40 and 42 in rats at oral doses as low as 1 mg/kg.
Journal of Medicinal Chemistry 2013 vol. 56 # 10 p. 3980 – 3995
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