Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1)

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Description

Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) video

APICMO offers a wide range of products which includes Tert-butyl 3-iodoazetidine-1-carboxylate. It belongs to intermediates category. Contact us for more information.

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Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Specifications

CAS 254454-54-1
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD09752821
InChI Key XPDIKRMPZNLBAC-UHFFFAOYSA-N
Chemical Name or Material tert-butyl 3-iodoazetidinecarboxylate;

tert-butyl 3-iodo-1-azetidinecarboxylate;

3-Iodoazetidine-1-carboxylic Acid tert-Butyl Ester;

tert-Butyl 3-Iodoazetidine-1-carboxylate;

1-(tert-Butoxycarbonyl)-3-iodoazetidine;

Infrared Spectrum No Data Available
Physical Form Clear Liquid at 20°C
Packaging Glass bottle
Molecular Formula C8H14INO2
Molecular Weight (g/mol) 283.11
SMILES CC(C)(C)OC(=O)N1CC(C1)I
Color Pale Yellow-Yellow at 20°C
Melting Point No Data Available
Assay 95%

Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Safety and HandlingAPICMO hazard icons

(254454-54-1) GHS H Statement

  • Harmful if swallowed [Warning Acute toxicity, oral]
  • Causes skin irritation [Warning Skin corrosion/irritation]
  • Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
  • Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Tert-butyl 3-iodoazetidine-1-carboxylate GHS P Statement

  • Avoid breathing dust/fume/gas/mist/vapours/spray.
  • Wash hands thoroughly after handling.
  • Wash skin thouroughly after handling.
  • Do not eat, drink or smoke when using this product.
  • Use only outdoors or in a well-ventilated area.
  • Wear protective gloves/protective clothing/eye protection/face protection.
  • IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Articles

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Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Bulk Ordering & Pricing:

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2 reviews for Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1)

  1. APICMO

    Are you in need of tert-butyl 3-iodoazetidine-1-carboxylate 254454-54-1 in large or small quantities? We at APICMO have got you covered as we produce, synthesize and manufacture large quantities of tert-butyl 3-iodoazetidine-1-carboxylate 254454-54-1 among many other chemicals.

    All our products adhere to CMPG regulations on quality control and all other manufacturing regulations so you can be sure to receive superior products from us. Our products will exceed your expectations as they are of the highest standards and quality in the market. Tert-butyl 3-iodoazetidine-1-carboxylate 254454-54-1 is in Azetidines category.

    What are Azetidines?

    These are very rare compounds that come in liquid form and have a strong ammonia odour. They help to dissolve various substances including several pharmaceuticals.

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Synonyms

    There are various different names all referring to the same product and their CAS number is 254454-54-1. They include;

    • Tert-butyl 3-iodoazetidinecarboxylate
    • Tert-butyl 3-iodo-1-azetidinecarboxylate
    • 3-Iodoazeditidine-1-carboxylic Acid tert-Butyl Ester
    • Tert-Butyl 3-Iodoazetidine-1-carboxylate
    • 1-(tert-Butoxycarbonyl)-3-iodoazetidine
    • 3-iodoazetidine,n-boc protected
    • N-Boc-3-iodo-azetidine
    • Tert-butyl 3-iodoazetidine carboxylate
    • 3-iodoazetidine-1-carboxylic acid tert-butyl ester
    • 1-Boc-3-iodoazetidine
    • N-Boc-3-iodo azetidine
    • 1-Boc-3-iodoazetidine, Adrich CPR
    • N-tert-butoxycarbonyl-3-iodoazetidine
    • N-Boc-3-iodoazetidine
    • 1-Boc-3-iodoazetidine
    • 1-n-boc-3-iodoazetidine
    • 1-boc-3-(iodo)azetidine
    • 3-iodo-azetidine-1-carboxylic acid tert-butyl ester

    (254454-54-1) Structural Formula

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) -APICMO Azetidines

    Tert-butyl 3-iodoazetidine-1-carboxylate Chemical and Physical Properties

    With a molecular formula of C8H14INO2, 254454-54-1 weighs 283.10700 g/mol in formula weight with an exact mass of 283.00700 g/mol.

    The density of tert-butyl 3-iodoazetidine is 1.63 g/cm3, with a flash point of 124.372 degree Celsius and the refractive index ranges from 1.590 to 1.530.

    The boiling point for 254454-54-1 is 282.037 degree Celsius at 760 mmHg a vapour pressure of 0.003 mmHg at 25 degree Celsius and 98% purity.

    254454-54-1 appears as a colourless to red brown liquid and should be stored cold.

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Computed Properties

    Property Name Property Value
    Covalently-Bonded Unit Count 1
    Isotope Atom Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Heavy Atom Count 12
    Formal Charge 0
    Compound Is Canonicalized Yes
    XLogP3-AA 1.9
    Monoisotopic Mass (g/mol) 283.007
    Topological Polar Surface Area 29.5A^2
    CACTVS Substructure Key ingerprint AADccByMAAAAgAAAAAAAAAAAA
    BYAAAAAAAAAAAAAAAAAAAAAAAAHgAg
    AAAADETDgAQCCAMABAAIAAAAGAAA
    AAAAAAAAAAAIAAAAAAAAAAAMAAAABgA
    AAAAAAAAAAAAAAAAAAAAAAAAAAAAA
    AAAAAAAAAA==
    Complexity 182
    Rotatable Bond Count 2
    Hydrogen Bond Acceptor Count 2
    Hydrogen Bond Donor Count 0

    Tert-butyl 3-iodoazetidine-1-carboxylate 254454-54-1 Synthesis Route

    Tert-butyl 3-iodoazetidine-1-carboxylate 254454-54-1 may be synthesised through five routes as indicated below;

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1)

     (254454-54-1) Applications

    254454-54-1 is used as an intermediate in the manufacturing of pharmaceutical drugs which can penetrate the brain to possibly treat Alzheimer’s disease.

     Tert-butyl 3-iodoazetidine-1-carboxylate Potential Health Hazards

    Tert-butyl 3-iodoazetidine-1-carboxylate may be toxic if in contact with eyes or skin if inhaled or ingested. It may also be very toxic to aquatic life if discharged to the environment.

    254454-54-1 may be harmful if ingested as it may irritate the gastrointestinal tract; do not eat, drink or smoke when dealing with this product.

    Inhalation of this 254454-54-1 in the form of dust, fumes, sprays, vapours or gas may irritate the respiratory system.

    Any contact of 254454-54-1 with eye s may cause severe eye irritation and damage. Skin irritation will occur if there is direct contact with 254454-54-1.

    254454-54-1 maybe toxic if discharged to the environment as it may have adverse and long-lasting effects to the aquatic life.

    (254454-54-1) Safety Measures

    First Aid Measures

    Inhalation

    In case anyone inhales 254454-54-1, in the form of dust, gas, vapours, or spray, evacuate them from the exposure. Bring the casualty outdoors where there is sufficient flow of fresh air, and then place them in a position comfortable for easy breathing.

    If breathing is difficult or it has stopped, administer artificial respiration or give oxygen. Never attempt to give mouth-to-mouth resuscitation to a victim of chemicals. Bring the casualty to a health facility for medical assistance.

    Ingestion

    If a victim ingests 254454-54-1 accidentally or otherwise; generously rinse the mouth with copious amounts of water. If the casualty is unconscious, do not attempt to give anything orally.

    If there is vomiting, place the casualty in a recovery position to prevent choking when the vomit gets back to the throat. Take the casualty to the hospital as soon as possible.

    Contact

    If there is direct contact of 254454-54-1 with the skin, wash the affected skin thoroughly with a copious amount of running water using a mild soap. Remember to remove any contaminated clothing and shoes as you continue cleaning. Thoroughly wash the contaminated clothing and shoes before you reuse them. Seek medical attention if the irritation persists.

    If in contact with eyes, cautiously flush your eyes with copious amount of water for about 15 minutes. As you do this, occasionally lift the upper and the lower eyelids to ensure you wash away as much chemical as possible. If in contact lenses and you can remove them easily, do so then continue flushing. Get to a health facility for medical aid.

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Handling and Storage

    Handling

    Handle 254454-54-1 carefully avoiding any contact with eyes and skin. Do not inhale this product whether in the form of spray, gas, or vapours. Avoid drinking, eating or smoking whenever you are handling 254454-54-1.

    Do not discharge to the environment or waters as it may be toxic to aquatic life. Avoid letting it to the air as it may be dangerous and may contaminate the air.

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Engineering Control

    Use a chemical fume hood when working on 254454-54-1 as it may be dangerous to the air. Ensure there is adequate ventilation in the facilities where this product is utilised or stored. Handle this product in compliance with safety practice and good industrial hygiene. Remember to wash your hands before you go for breaks and at the end of a workday.

    Personal Protection

    Use appropriate and approved personal protective equipment when handling this product which includes;

    • Wear a complete protective suit to shield your body from any direct contact with 254454-54-1. The suitable protective clothing should be selected in consideration of the amount of danger of the substance, and its concentration which should be specific to the workplace.
    • Impervious gloves or gauntlets that is resistant to chemicals for protecting your hands from direct contact with tert-butyl 3-iodoazetidine-1-carboxylate. These gloves must be inspected prior to use. The gloves should meet the government specifications such as EU Directive 89/686/EEC and their standards EN 374. Use the suitable technique to remove gloves; avoid touching the outer surfaces of the used gloves to prevent contact with 254454-54-1. Follow good laboratory practice and the applicable laws when you are disposing of the contaminated gloves. Always wash and dry your hands before breaks and after a workday.
    • Wear appropriate and approved safety glasses and face mask to shield your eyes from contact with 254454-54-1; these should meet the  government’s standards such as EN 166 (EU) or NIOSH (US).
    • Wear an approved full-face respirator which should have a multi-purpose combination (US). Alternatively, use type ABEK (EN 14387) respirator cartridges as engineering control back up.
    • Always wash your hands prior to breaks and after a day’s work.
    • Wash your body after handling this product to ensure personal hygiene.

     Tert-butyl 3-iodoazetidine-1-carboxylate Storage

    Store in a tightly closed container and keep it locked in a cold place with adequate ventilation. Reseal any opened containers carefully then keep them upright to prevent spillages.

    Store away from the light as 254454-54-1 is sensitive to light.

    Keep it under Argon gas before storing.

     (254454-54-1) Stability and Reactivity

    254454-54-1 is generally stable when stored at the recommended conditions. Store this product cold under Argon gas.

    Store in a dark place as it is sensitive to light.

    Special possible hazardous combustion products are; Hydrogen Iodide, Nitrogen Oxides and Carbon Oxides. 

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Disposal Method

     Product

    Arrange for collection of any surplus chemical that is not recyclable by a licensed waste disposal company. Consult your local waste disposal authority and comply with the local, regional and national regulations on the disposal of this product.

     Contaminated Packaging

    Dispose of any contaminated packaging as unused product.

    Spillages or leakages

    Do not allow any discharge to the environment as this product is dangerous if released into the air; also it’s toxic to the aquatic life and may cause long-lasting effects if allowed to enter water drains.

    If any spillage or leakage occurs, prevent further leakage or spillage if there it’s not risky. Use an inert absorbent material such as vermiculite or sand to soak up the spill. Sweep up and collect into a well-labelled container awaiting disposal.

     Tert-butyl 3-iodoazetidine-1-carboxylate Fire Fighting Measures

    In the event of a fire involving 254454-54-1 alone or with other materials; put off the fire using dry powder, alcohol-resistant foam, carbon dioxide or water spray.

    Technical Service

    At APICMO, we pride in our team of excellent scientists who are professional in different fields of research; they have experience in Material Science, Chemical Synthesis and Analysis, Chromatography, Life Science and much more. 

    Tert-butyl 3-iodoazetidine-1-carboxylate (254454-54-1) Bulk Ordering and Pricing

    Whatever you need a bulk supply of tert-butyl 3-iodoazetidine-1-carboxylate 254454-54-1for either research, development or manufacturing; contact us through our customer care desk, and we will sort you out.

    Bibliography

    1. Claffey, Michelle M.; Helal, Christopher J.; Verhoest, Patrick R.; Kang, Zhijun; Fors, Kristina S.; Jung, Stanley; Zhong, Jiaying; Bundesmann, Mark W.; Hou, Xinjun; Lui, Shenping; Kleiman, Robin J.; Vanase-Frawley, Michelle; Schmidt, Anne W.; Menniti, Frank; Schmidt, Christopher J.; Hoffman, William E.; Hajos, Mihaly; McDowell, Laura; Oconnor, Rebecca E.; MacDougall-Murphy, Mary; Fonseca, Kari R.; Becker, Stacey L.; Nelson, Frederick R.; Liras, Spiros Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9055 – 9068.
    2. National Centre For Biotechnology Information, US. National Library Of Medicine, PubChem,tert-butyl 3-iodoazetidine-1-carboxylate 254454-54-1, Sections 1-9.
    3. Koichi Mikami, Mark Lautens, John Wiley & Sons, 4 May 2007,  Science, New Frontiers in Asymmetric Catalysis, page 400-405.
    4. Aiwen Lei, Wei Shi, Chao Liu, Wei Liu, Hua Zhang, Chuan He, John Wiley & Sons, 14 Nov 2016,  Science, Oxidative Cross-Coupling Reactions, page 120-125.
  2. Rated 5 out of 5

    Apicmo

    The best Tert-butyl 3-iodoazetidine-1-carboxylate and service i have ever had,Nice experience

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