2-Chloro-5-methylpyrimidine (22536-61-4)

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The ability to produce, synthesize and manufacture large quantities of 2-Chloro-5-methylpyrimidine (22536-61-4) with quality control system under CGMP manufacturing



2-Chloro-5-methylpyrimidine (22536-61-4) video

2-Chloro-5-methylpyrimidine 22536-61-4 product specifications

CAS  no 22536-61-4
Chemical name 2-Chloro-5-methylpyrimidine
IUPAC name 2-chloro-5-methylpyrimidine
Flashpoint (°C) 121.53
Boiling point (°C) 23.18
Melting point (°C) 89 to 92
Molecular formula C5H5CIN2
Density per mole 1.169 grams per mole at 25 degrees centigrade
Molecular weight 128.559 g/mol
Monoisotopic mass 128.014 g/mol
Physical state Powder
Structural formula 2-Chloro-5-methylpyrimidine (22536-61-4)
Synonyms 2-chloro-5-methyl pyrimidine






2 reviews for  2-Chloro-5-methylpyrimidine (22536-61-4)


    APICMO has proven its worth and that it can be trusted when it comes to the synthesis and production of chemical products. We have the necessary technology, equipment, and expertise required to produce high-quality products, one of them being 2-Chloro-5-methylpyrimidine 22536-61-4, a chemical that has been carefully manufactured to meet the rules and regulations of CGMP and the quality control system.

    2-Chloro-5-methylpyrimidine (22536-61-4) description

    This chemical is a light yellow crystalline powder at room temperature. The color appears like off-white. It can be produced following many methods, but the common one is synthesizing it through the reaction of phosphorus oxychloride and 3-methylpyridine 1-oxide. This method helps in obtaining the chemical as 25% of the product. However, for higher yields, the reaction is carried out but with the presence of an organic nitrogen compound and an inert organic solvent. The process is performed in a temperature range of between -50 degrees to 50 degrees.

    The processes keep changing, and it is possible to attain up to 70% of the product based on the method used. The method used depends on the amount of the chemical one wishes to produce or how one intends to use the chemical.

    2-Chloro-5-methylpyrimidine 22536-61-4 applications

    It is mostly used as;

    • A pesticide intermediate
    • Bactericide
    • Herbicide
    • Pharmaceutical intermediate
    • Petrochemical addictive
    • Catalytic agent

    This product has also been used in making products like neonicotinoid compounds, which entail insecticidal activity and in the synthesize of acetamirid, imidacloprid NTN32693, and Nitenpyram, all which are used both in industrial and residential farms to get rid of insects that are bound to destroy fruits, cereals or vegetables.

    2-Chloro-5-methylpyrimidine 22536-61-4 chemical structure

    2-Chloro-5-methylpyrimidine (22536-61-4)

    2-Chloro-5-methylpyrimidine chemical and physical properties

    Solubility of 2-Chloro-5-methylpyrimidine

    The chemical is slightly soluble in water

    22536-61-4 hydrogen bonding

    Rotatable bond count 0
    Hydrogen bond acceptor count 2
    Hydrogen bond donor count 0

    2-Chloro-5-methylpyrimidine appearance

    This chemical is an off-white powder. You would also want to note that it is odorless.

    2-Chloro-5-methylpyrimidine computed properties

    Covalently-Bonded Unit Count 1
    Isotope Atom Count 0
    Defined Bond Stereocenter Coun 0
    Undefined Bond Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Undefined Atom Stereocenter Coun 0
    Heavy Atom Count 8
    Compound Is Canonicalized True
    Formal Charge 0
    XLogP3-AA 1.5
    Topological Polar Surface Area 25.8 A^2
    Complexity 68.8

    2-Chloro-5-methylpyrimidine synthesis route

    The product has four synthesis routes as follows;

     2-Chloro-5-methylpyrimidine (22536-61-4)

    2-Chloro-5-methylpyrimidine precursor and downstream products


     2-Chloro-5-methylpyrimidine (22536-61-4)

    Product downstream

     2-Chloro-5-methylpyrimidine (22536-61-4)

    2-Chloro-5-methylpyrimidine uses

    • This chemical is mostly used in organic synthesis
    • Used as a pesticide intermediate
    • Herbicide
    • Bactericide
    • Used as catalytic
    • Petrochemical additive
    • Used in industrial and residential farms for the destruction of hazardous insects

    Hazards associated with 2-Chloro-5-methylpyrimidine

    GHS classification symbol

    APICMO hazard icons

    • This chemical can lead to eye irritation
    • Leads to skin irritation, corrosion, soreness and redness, and soreness
    • It is harmful if swallowed
    • It is detrimental to the respiratory tract if accidentally inhaled

    2-Chloro-5-methylpyrimidine safety measures

    Personal protection

    Never forget to put on protective clothes before handling this chemical. This includes resistant gloves, protective glasses, and a face mask. This is to protect yourself from coming to contact with your skin, eyes, accidental ingestion or inhaling it.

    1. 2-Chloro-5-methylpyrimidine engineering controls

    Make sure that your laboratory or working area is well equipped with safety measures. These include a fire extinguisher, a safety shower, vapor compressor, fume hoods, air cleaner and taps with running water. Also, ensure that the room is well ventilated.

    2. First aid measures

    Sometimes you could accidentally get into contact with this chemical. In such situations, this is what to do;

    • When it comes into contact with eyes

    Quickly run to the tap and rinse your eyes with clean water for about 15 minutes. If you have lenses on, make sure to remove them first for easier cleaning.

    • Skin contact

    This chemical is very harmful to the skin and could even lead to corrosion. Immediately rush to the shower and rinse the affected area thoroughly with plenty of water and non-abrasive soap.

    • In a case of accidental ingestion

    You should quickly rinse your mouth before taking about half a liter of water. Note that you should never induce vomiting. Also, ensure to see a pharmacist for further assurance.

    • When accidentally inhaled

    The victim should be transferred to an open or well-ventilated area. If the person is experiencing breathing difficulties, try and administer artificial oxygen before rushing him/her to the nearest medical facility for further assistance.

    3. 2-Chloro-5-methylpyrimidine storage

    22536-61-4 is known to be a stable chemical if stored under the ideal conditions. Store it at room temperature. Do not use an aluminum or galvanized container for storage since the two compounds can react with the chemical leading to an explosion. Make sure that the containers are tightly closed and that there are no signs of leaks.

    4. Things to do when handling 22536-61-4

    • Avoid inhaling this chemical’s fumes, vapor or dust
    • Ensure that it does not come into contact with your skin by putting on protective clothes
    • Ensure that you are operating from a well-ventilated area

    5. Things to do after you are done working with 2-Chloro-5-methylpyrimidine

    After you are done, ensure to take the following measures;

    • Start by observing your hygiene. Wash your hands before taking a shower
    • Wash all the clothes you had on when working with the product
    • Get rid of any empty containers and ensure to follow your local and federal rules and regulations when disposing them
    • Ensure to store the remaining product as per the regulations

    6. Accidental measures

    In the event of accidents in the lab, here is what to do.

    • In a case of fire

    You can use carbon IV) oxide, dry chemical fire extinguishers, alcohol-resistant extinguishers or polymer foam. Try and put on protective firefighting gears and breathing apparatus for further safety.

    • Spillage

    Use an absorbent material to soak up the spill before disposing it in a waste container. Use a vapor compressor to reduce mist around the affected area before using lots of water to clean the area thoroughly.

    7. 22536-61-4 stability

    This product is stable, provided that it is used and stored under appropriate pressure and temperature conditions.

    8. 2-Chloro-5-methylpyrimidine waste disposal

    You should treat this product as special waste, and you should, therefore, dispose it as per the local, federal and international waste disposal regulations.

    9. 2-Chloro-5-methylpyrimidine shipping info

    2-chloro-5-methylpyridimine is stable and non-hazardous. It can, therefore, be transported comfortably by air or sea. The chemical is highly reactive with carbon dioxides, hydrogen oxides, and nitrogen oxides. It is, therefore, recommendable to choose a transportation option that does not expose it to any of these compounds.

    Regulatory info

    Ensure to observe the local, federal and international rules and regulations at all stages of handling this product.

    Technical details

    Experts synthesize the chemical. Our technicians have had extensive experience in chemical synthesis, chromatography, material science, and products analysis.

    2-Chloro-5-methylpyrimidine ordering and pricing

    This chemical is meant for research, manufacturing and chemical development. If you plan on using the chemical for any of the mentioned purposes, feel free to make orders from us.


    1. National Centre For Biotechnology Information, US. National Library Of  Medicine, PubChem,2-Chloro-5-methylpyrimidine Sections 1-10
    2. DJ Brown; and T Lee. Pyrimidine reactions. XVI. Thermal rearrangement of substituted 2- and 4-alkoxypyrimidines. Australian Journal of Chemistry.196821(1), 243 – 255.
    3. Desmond J Brown. The chemistry of Heterocyclic Compounds, page 4-5.
  2. Rated 5 out of 5


    The best 2-Chloro-5-methylpyrimidine and service i have ever had,Nice experience

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