2-chloro-5-aminopyrimidine (56621-90-0)

(2 customer reviews)

This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of 2-chloro-5-aminopyrimidine (56621-90-0) with quality control system under CGMP manufacturing
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Description

2-chloro-5-aminopyrimidine (56621-90-0) video

5-Bromopyrimidine was used in the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction, (5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol.

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5-Bromopyrimidine (4595-59-9) Specifications

CAS 4595-59-9
CAS Min % 97.5
CAS Max % 100.0
MDL Number MFCD00006117
InChI Key GYCPLYCTMDTEPU-UHFFFAOYSA-N
Chemical Name or Material 5-Bromopyrimidine
Assay Percent Range 98%
Physical Form Solid
Packaging Glass bottle
Molecular Formula C4H3BrN2
Molecular Weight (g/mol) 158.986
SMILES C1=C(C=NC=N1)Br
Color White-Yellow
Melting Point 69.0° to 73.0°C
Assay 98%

5-Bromopyrimidine (4595-59-9) Safety and HandlingAPICMO hazard icons

(4595-59-9) Hazard description:

  • Causes serious eye irritation.
  • Causes skin irritation.

5-Bromopyrimidine Precautionary statement:

IF ON SKIN: Wash with plenty of soap and water.

Wear protective gloves/protective clothing/eye protection/face protection.

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

5-Bromopyrimidine (4595-59-9) Articles

A rosuvastatin calcium impurities in the intermediate preparation method (by machine translation)

The invention discloses a preparation method for a rosuvastatin calcium intermediate impurity. The preparation method comprises: by taking formaldehyde and [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-methanesulfonamino)-5-pyrimidyl] triphenylphosphonium bromide as raw materials…

Xie Yongju; Gong Jie 2018

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5-Bromopyrimidine (4595-59-9)Bulk Ordering & Pricing:

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2 reviews for 2-chloro-5-aminopyrimidine (56621-90-0)

  1. APICMO

    Have you been looking for a good supply of large quantities of 2-chloro-5-aminopyrimidine (56621-90-0)? Here at APICMO, we have a reliable solution for you. We have experts with the expertise to produce 2-chloro-5-aminopyrimidine in small and large amounts. All our products satisfy the manufacturing regulations of CGMP.

    2-chloro-5-aminopyrimidine description

    Chloro-5-aminopyrimidine alternatively known as 2-chloro-5-aminopyrimidine or 2-Chloro-pyrimidin-5-ylamine is a pyrimidine of 2, chromoro-5-aminoprimidine. Despite having a human effect and strength over time, you need to be careful when using it because it can cause depression and skin inflammation.

    This product is in the category of pyrimidines.

    Chemical structure of 2-chloro-5-aminopyrimidine

    2-chloro-5-aminopyrimidine (56621-90-0)

    Synthesis routes of 2-chloro-5-aminopyrimidine

    2-chloro-5-aminopyrimidine has two synthesis routes

    2-chloro-5-aminopyrimidine (56621-90-0)

    10320-42-0

    2-chloro-5-nitro…

    2-chloro-5-aminopyrimidine (56621-90-0)

    56621-90-0

    5-amino-2-chloro…

    2-chloro-5-aminopyrimidine (56621-90-0)

    326-19-6

    5-nitro-1H-pyrim

    2-chloro-5-aminopyrimidine (56621-90-0)

    56621-90-0

    5-amino-2-chloro…

    2-chloro-5-aminopyrimidine (56621-90-0) precursor and precursor products

    Precursor products:

    2-chloro-5-aminopyrimidine (56621-90-0)

    2364-10-6

    2-chloro-5-aminopyrimidine (56621-90-0)

    1032-42-0

    Downstream products:

    2-chloro-5-aminopyrimidine (56621-90-0)

    582323-10-2

    2-chloro-5-aminopyrimidine (56621-90-0)

    582323-16-8

    2-chloro-5-aminopyrimidine (56621-90-0)

    4983-28-2

    2-chloro-5-aminopyrimidine product specifications

    Chemical Name 2-chloro-5-aminopyrimidine
    IUPAC  Name 2-chloropyrimidin-5-amine
    Assay 96%
    Melting Point 198-199 ° C
    Molecular Weight 129.549g/mol.
    Molecular Formula C4H4ClN3
    Infrared Spectrum True
    Inchi 1S/C4H4ClN3/c5-4-7-1-3(6)2-8-4/h1-2H,6H2
    Inchi Key DZBKIOJXVOECRA-UHFFFAOYSA-N
    CAS Number 56621-90-0
    CAS Min 95%
    CAS Max 100%
    IUPAC Name
    Canonical SMILES COC1 = CN = C (Cl) N = C1
    Synonyms

     

    1. 2-CHLORO-5-AMINOPYRIMIDINE
    2-CHLORO-5-PYRIMIDINAMINE
    2. 2-Chloropyrimidin-5-amine
    2-Chloropyrimidin-5-ylamine
    3. 2-Chloro-pyrimidin-5-ylamine
    2-CHLORO-PYRIMIDINE-5-AMINE
    4. 2-chloropyrimidine-5-ylamine
    4CH-001090
    5. 56621-90-0
    56621-90-0 5-amino-2-chloropyrimidine
    5-AMINE-2-CHLOROPYRIMIDINE
    5-amino-2-chloro pyrimidine
    6. 5-Amino-2-chloropyrimidine
    5-amino-2-chloropyrimidine, AldrichCPR
    7. 5-PYRIMIDINAMINE, 2-CHLORO-
    5-Pyrimidinamine, 2-chloro- (9CI)
    5-Pyrimidinamine,2-chloro-
    621A900
    AB0025545
    AB1006193
    AC-4602
    8. ACMC-1AXFH
    ACT01635
    AJ-77115
    AK-24171
    AKOS006280308
    AM20100394
    AN-11808
    ANW-32561
    AX8002227
    BCP23418
    BR-24171
    C-01240
    C-1663
    CA0100
    CA-1644
    CC-21115
    CJ-16669
    CS-W005338
    CTK5A5459
    DB-010236
    DTXSID60480849
    DZBKIOJXVOECRA-UHFFFAOYSA-N
    FCH836002
    FT-0640401
    HC210150
    HP21136
    KB-169841
    KB-23304
    KS-0000037F
    LS20481
    MFCD06412560
    MolPort-000-140-202
    OR30541
    PB21893
    PS-4730
    PubChem6963
    9. Q-102843
    QC-1705
    RP00932
    SBB051953
    SC-05394
    SCHEMBL40450
    ST1141034
    SY013941
    TC-067988
    TL8003661
    TRA0015152
    VP50264
    W7026
    WT624
    ZINC20357595
    ZX-AT005418

    Chemical and physical properties of 2-chloro-5-aminopyrimidine

    Appearance:

    2-chloro-5-aminopyrimidine exists as a red powder.

    Bonding:

    Covalent bonds count 1 unit
    Rotatable bonds count None
    Hydrogen bonds Donor-1unit
    Acceptor-3 units

    Computed properties of 2-chloro-5-aminopyrimidine

    Name of the property Value
    Count of isotope atom 0
    Streocenter defined bond count 0
    Sttereocenter undefined bond count 0
    Stereocenter determined atom count 0
    Stereocenter undefined atom count. 0
    Count of heavy atom 8
    XLogP3-AA 0.5
    Formal Charge 0
    Is the compound canonicalized Yes
    Exact mass 129.009 g/mol.
    Mon isotopic mass 129.009 g/mol.
    Surface area of the topological polar 51.8 A^2
    CACTVS substructure key fingerprint AAADcYBjAAAEAAAAAAAAAAAAAAAAAA
    AAAAAsAAAAAAAAAAABgAAAHAIQAAAA
    CAjBEgQt0JZIEACgABRnZACAgCkREqABU
    CAodBCASIBASUAUBAgIEAJAACAAAAAAAA
    AAAAAAAAAAAAAAAAAAAAAAAAAAAA==
    Complexity 69.7

    Uses of 2-chloro-5-aminopyrimidine

    2-chloro-5-aminopyrimidine is useful in research, development and product synthesis.

    Safety measures in handling 2-chloro-5-aminopyrimidine

    When working with 2-chloro-5-aminopyrimidine for research, development or product synthesis, you are required to take great care. This is because the outcome may have harmful results on your health if mishandled. The following is detailed information on safety measures to consider while working with 2-chloro-5-aminopyrimidine.

    2-chloro-5-aminopyrimidine related hazards.APICMO hazard icons

    • The product is hazardous upon inhalation.
    • Harmful to the eyes causes severe eye irritation.
    • This product may cause respiratory displeasure.
    • It is harmful upon ingestion.
    • It may result in skin corrosion.

    Equipment for personal protection

    When working with7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9), it is important to protect your skin, eyes as well as the respiratory system using safety equipment. This keeps your body safe from the listed hazards.

    Skin protection

    • Put on impenetrable safety clothing.
    • Ensure that the clothing is long-sleeved to cover your entire body.
    • Gloves are necessary to cover your hands.

    Eye and face protection

    • Cover your eyes with safety goggles.
    • The goggles might be fitted with side shield to cover the face.

    Respiratory protection

    Under normal conditions, respiratory protection may not be necessary.However, avoid inhalation of dust, vapors, fumes, gases or spray. Respirators may be kept ready for emergencies.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) safety measures

    1. Engineer control

    The laboratory should have enough ventilation or work outdoors.

    2. 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) handling

    When in use:

    • Do not use the product before obtaining proper instructions.
    • Read and understand the instructions given
    • Wear safety equipment and clothing.
    • Do not release the product into the environment.
    • Avoid smoking, taking beverages or foods when working with the chemical.
    • Do not burn the product.
    • Avoid grinding or subjecting the chemical to frictions.
    • Avoid working with the chemical while pregnant or during nursing.
    • Do not heat chemical under confinement.

    After use

    • Store the unused product in a storage bottle and lock it.
    • Collect the waste and empty cans and package them for disposal. The disposal containers ought to be labeled and locked up.
    • Take out the contaminated clothes.
    • Do not take the contaminated clothes out of the workplace or reuse them before washing them.
    • Remove the gloves carefully and dispose of them properly as required by the federal or local regulations.
    • Clear off the working bench and wash it.
    • Clean your face and hands thoroughly with enough cold water.

    3. Storage measures for 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    When 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) is not in use, ensure that you store the chemical under the following conditions.

    • Always use the original container to store the chemical and cork it tightly
    • Label the bottle appropriately.
    • Keep out of reach of unauthorized persons and children.
    • The storage space should have a sufficient supply of fresh air.
    • Keep the chemical away from direct sunlight and heat.

    4. First aid measures

    Accidental occurrences may take place any time you are working with2-chloro-5-aminopyrimidine. Seeking medical attention in the event of these risks is important. Since medics may not be accessible immediately, it is important to administer the following first aid measures to the casualties before getting to the physicians.

    In case of ingestion:

    • Use plenty of cold water to rinse the mouth.
    • If the victim is unconscious, do not administer anything through the mouth.
    • Visit or call a medic for help.

    In case of inhalation of the chemical:

    • Transfer the casualty outdoors or to a place with sufficient ventilation.
    • Call a medic for further treatment.

    When in contact with the eyes:

    • Wash the eyes with a large amount of cold water.
    • Take out eye contact lens if you have them.
    • Continue rinsing the eyes for about ten minutes.
    • In case of persistence of the irritation, consult a physician.

    When in contact with the skin

    • Brush off the particles from the site of contact.
    • Clean the affected area for about 15 minutes with sufficient cold water and soap.

    5. Accidental spillage measures

    Use sand or vermiculite to absorb the spillages. Pack the spillages in appropriate containers for disposal.

    6. Firefighting measures

    2-chloro-5-aminopyrimidine or its constituent may trigger a fire. If this happens accidentally, the following are the precautions you should consider.Use polymer foam, alcohol resistant, dry chemical powder or carbon dioxide to put off the fire.In case of explosions, stop fighting the fire and evacuate the area. Wear safety equipment and clothing when extinguishing the fire.

    7.  2-chloro-5-aminopyrimidine shipping measures

    2-chloro-5-aminopyrimidine is not hazardous for ground and air transportation.

    8.  Disposal of waste

    Gather the wastes and arrange as special waste ready for disposal.Hand over the waste to a licensed waste disposal company.Handle the waste according to the federal, national or local laws on waste disposal.

    9. 2-chloro-5-aminopyrimidinereactivity and stability

    Under suitable storage conditions, the product is stable.

    The product should not be exposed to strong oxidizers or acids.

    Combustion of 2-chloro-5-aminopyrimidine produces carbon chloride, carbon oxides, and nitrogen oxides.

    Regulatory information

    2-chloro-5-aminopyrimidine is a product classified for research and development purposes; it is therefore not for human or animal use. The product ought to be handled and kept under the recommended conditions. It is to be treated by trained personnel with expertise in laboratory procedures. This should be under the inspection of recognized supervisors.

    Technical service

    You can be sure of quality products and services from us at APICMO. This is because we have a team of experts committed to development and research in a wide range of fields including chromatography, chemical science, life science analytical science and others.

    2-chloro-5-aminopyrimidine bulk ordering and pricing

    Are you in need of 2-chloro-5-aminopyrimidine in large quantities for your development, research or product synthesis? Do not hesitate; our dedicated customer care department is always ready to listen to you. Contact us and make your orders.

    Bibliography:

    1. National Centre for Biotechnology Information, U.S. National Library of Medicine ,Pubchem, 2-chloro-5-aminopyrimidine , Sections 1-9.Pathway Therapeutics Limited Patent: US2011/9405 A1, 2011 ; Location in patent: Page/Page column 56 ;
    2. Desmond J. Brown, John Wiley & Sons, 15 Sep 2009, The Pyrimidines, page 153,167,316,469, 503.
    3. Robert Cooley ElderfieldWiley, 1957 – Heterocyclic compounds, page 206, 270, 305.

  2. Apicmo

    The best 2-chloro-5-aminopyrimidine and service i have ever had,Nice experience

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