2-Amino-5-cyanopyridine (4214-73-7)

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2-Amino-5-cyanopyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

The adsorption of 2‐amino‐5‐cyanopyridine (2‐ACP) was investigated in solution at different pH values by in situ surface‐enhanced Raman scattering (SERS) spectroscopy combined with the electrochemical method. The assignments of the main bands were first performed on the basis of the spectral features of similar compounds and with the help of density functional theory calculations. The results revealed that the adsorption and the interfacial structure of 2‐ACP on the Au electrode depended on the applied potential and the pH values of the solution. In the natural solution, 2‐ACP was adsorbed on the surface with a vertical orientation by the CN group from − 0.4 to − 1.0 V, whereas in the − 0.4 to 0.8 V range, the N atom of the pyridine ring was bound to the surface. A transition region for the reorientation of the two adsorption modes was observed from − 0.8 to − 0.4 V. A flat configuration was preferred at an extremely negative potential. A similar surface adsorption behavior was observed in the alkali environment, while the Stark effect slope decreased because of the adsorption of OH−. Due to the protonation of N atom in the acidic solution, the potential region for the coexistence of two configurations ranged from − 0.4 to 0.2 V. Additionally, a similar adsorption configuration was proposed on the Au colloids at various pH values. The results revealed that the adsorption behavior became more complex on colloidal surfaces than that on a rigid electrode surface.

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2-Amino-5-cyanopyridine (4214-73-7) Specifications

CAS 4214-73-7
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD00128902
Chemical Name or Material 2-Amino-5-cyanopyridine
Infrared Spectrum Authentic
Physical Form Powder
Packaging Glass bottle
Molecular Formula C6H5N3
Molecular Weight (g/mol) 119.12
Color Brown
Melting Point 159-163 °C
Assay 98%


2-Amino-5-cyanopyridine (4214-73-7) Safety and Handling

(4214-73-7) GHS H Statement

APICMO hazard icons

  • Toxic in contact with skin
  • Harmful in contact with skin
  • Causes serious eye irritation
  • Harmful if inhaled
  • Causes skin irritation

 2-Amino-5-cyanopyridine GHS P Statement

  • Avoid breathing dust/fume/gas/mist/vapours/spray.
  • Wash hands thoroughly after handling.
  • Wash skin thouroughly after handling.
  • Do not eat, drink or smoke when using this product.
  • Use only outdoors or in a well-ventilated area.
  • Wear protective gloves/protective clothing/eye protection/face protection.
  • IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

2-Amino-5-cyanopyridine (4214-73-7) Articles

Microwave-assisted MgO NP catalyzed one-pot multicomponent synthesis of polysubstituted steroidal pyridines

The present study reports a highly efficient and green synthetic route for the synthesis of steroidal pyridines. The synthetic methodology involves a microwave-assisted one-pot multicomponent reaction using MgO NPs as a heterogeneous, mild and reusable catalyst.

New Journal of Chemistry 2018 vol. 42 # 1 p. 184 – 197

Hexahydrospiro-pyrazolo[3,4-b]pyridine-4,1′-pyrrolo[3,2,1-ij]quinolines Derived from 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione

The tricyclic isatin, 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione (1), reacts with a combination of an aryl cyanomethyl ketone 8 and a 5-amino-1-arylpyrazole 7 to generate spirocyclic products 9

Journal of Heterocyclic Chemistry 2018 vol. 55 # 5 p. 1176 – 1182

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