3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

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This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) with quality control system under CGMP manufacturing
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Description

3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) video

APICMO offers a wide range of products which includes 3-Amino-6-chloropyridine-2-carboxamide. It belongs to intermediates category. Contact us for more information.

3-Amino-6-chloropyridine-2-carboxamide should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire.

Store in closed vessels, refrigerated.

This product(s) resides on a APICMO contract. If you are viewing this page as a non-registered user, the price(s) displayed is List Price. To view your pricing, log in using your account number, or become a registered user by contacting one of our Customer Service teams. To place an order, contact APICMO Customer Service.

3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Specifications

CAS 175358-01-7
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD09750671
InChI Key ZGGQDDSXBIALBC-UHFFFAOYSA-N
Chemical Name or Material 3-Amino-6-chloropyridine-2-carboxamide
Infrared Spectrum Authentic
Physical Form Powder
Packaging Glass bottle
Molecular Formula C6H6ClN3O
Molecular Weight (g/mol) 171.58
SMILES
Color Brown
Melting Point 174-181°C
Assay 98%

 

3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Safety and Handling

(175358-01-7) GHS H StatementAPICMO hazard icons

  • Harmful if swallowed
  • Causes skin irritation
  • Causes serious eye irritation
  • Harmful if inhaled
  • May cause respiratory irritation
  • Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
  • General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
  • Engineering Controls: Use only in a chemical fume hood.

3-Amino-6-chloropyridine-2-carboxamide GHS P Statement

  • P261+P305+P351+P338
  • Avoid breathing dust/fume/gas/mist/vapours/spray
  • IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses if present andeasy to do – continue rinsing

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Articles

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer’s disease is the alignment of potency, drug-like properties, and selectivity over related aspartyl proteases such as Cathepsin D (CatD) and BACE2. The potential liabilities of inhibiting BACE2 chronically have only recently begun to emerge as BACE2 impacts the processing of the premelanosome protein (PMEL17) and disrupts melanosome morphology resulting in a depigmentation phenotype.

Journal of Medicinal Chemistry 2018 vol. 61 # 10 p. 4476 – 4504

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors 

An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and highly brain penetrant BACE1 inhibitor, was able to reduce significantly CSF Aβ40 and 42 in rats at oral doses as low as 1 mg/kg.

Journal of Medicinal Chemistry 2013 vol. 56 # 10 p. 3980 – 3995

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Bulk Ordering & Pricing:

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2 reviews for 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

  1. APICMO

    Are you interested in research, development, drug discovery, and manufacturing of products? APICMO got you covered. We produce and synthesize large amounts of pure quality 3-Amino-6-chloropyridine-2-carboxamide with quality control system under the current good manufacturing practices (cGMP). This product is subject to APICMO contract.

    The structural formula of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7):

    3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    About 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    3-Amino-6-chloropyridine-2-carboxamide is an organic compound falling under the group of pyridines. It is an intermediate product, which you can use in the pharmaceutical industry and scientific research. For additional info about the chemical, feel free to get in touch with our active online support team.

    Uses of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    This chemical is a useful pharmaceutical intermediate. It is currently used in the study, drug discovery, and treatment of Alzheimer’s disease.

    Depositor-Supplied Synonyms

    • 3-Amino-6-chloropyridine-2-carboxamide
    • 2-pyridinecarboxamide,3-amino-6-chloro-
    • 3-amino-6-chloropicolinamide
    • 3-amino-6-chloro-pyridine-2-carboxide
    • 3-amino-6-chloro-pyridine-2-carboxylic acid amide
    • 6-chloro-3-aminopyridine-2-carboxamide
    • 3-amino-6-chloro-2-pyridinecarboxamide
    • 3-amino-6-chloropyridine-2-carboxylc acid amide
    • ZGGQDDSXBIALBC-UHFFFAOYSA-N
    • 175358-01-7
    • PubChem19596
    • CTK4D5905
    • SCHEMBL668419
    • RTR-007976
    • PB16164
    • CM14027
    • AKOS006328789
    • ZINC40450007
    • ANW-61437
    • KS-000019OU
    • MolPort-016-578-683
    • DTXSID70444290
    • TR-007976
    • DB-012954
    • AJ-103203
    • TS-00160
    • KB-45150
    • BP-11823
    • AM803352
    • AC-27978
    • WT82342
    • I14-14453
    • Q-1754
    • ST24041769
    • FT-0660694
    • CS-0053878
    • BB 0261175

    175358-01-7 Product Specifications

    Boiling point (˚C) 349.303
    Canonical SMILES C1=CC(=NC(=C1N)C(=O)N)Cl
    CAS no. 175358-01-7
    Chemical name 3-Amino-6-chloropyridine-2-carboxamide
    Density (g/cm3) 1.484
    Empirical formula C6H6ClN3O
    Flash point (˚C) 165.053
    Formula weight (g/mol) 171.5843
    IUPAC name 3-Amino-6-chloropyridine-2-carboxamide
    Melting point (°C) 174 – 181
    Monoisotopic mass (g/mol) 171.02
    Physical State Solid
    Purity 98%

    Physical & Chemical Properties of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    175358-01-7 bonding

    Covalent 1 unit
    Hydrogen bond Donor count – 2
    Acceptor count – 3
    Free rotatable bond 2

    The appearance of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    This organic compound is a brown solid, available in powder form.

    Stability

    3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) is unstable under high temperatures and strong oxidants. Keep it away from ignition sources.

    3-Amino-6-chloropyridine-2-carboxamideComputed Properties

    Property Name Property value
    XLogP3-AA 0.9
    Vapor pressure (mmHg) 0 at 25°C
    Undefined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Topological polar surface area 82 A^2
    Surface tension (dyne/cm) 72.73
    Refractive index 1.655
    Isotope Atom Count 0
    Heavy Atom Count 11
    Formal Charge 0
    Exact Mass (g/mol) 171.02
    Enthalpy of vaporization (kJ/mol) 59.378
    Defined Bond Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Compound is Canonicalized True
    Complexity 164

    Recommended Synthesis Route for 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    The Precursor and Downstream Products of 3-Amino-6-chloropyridine-2-carboxamide

    Downstream

    3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    Precursors

    3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) GHS Hazard DescriptionAPICMO hazard icons

    The GHS system of classification has labelled 3-Amino-6-chloropyridine-2-carboxamide as an irritant. Bearing the H-codes H335, H332, H319, H315, and H302, the product belongs to category-four hazards. It is detrimental to one’s health if it is swallowed, ingested, falls on the skin, or gets on the eyes. The damage may be acute or mild with probabilities of permanent effects, especially to the eye.

    The symptoms related to the eye include pain or reddening. To the skin, you are likely to observe scaling, dryness, reddening,or pain.If the exposure period is prolonged and the responsive measures are belated, the victim may seriously ail or die.

     Safety Precautions when using 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    Handling 3-Amino-6-chloropyridine-2-carboxamide

    Unless you are an expert or supervised by technically qualified personnel, do not experiment with this product. Make sure to understand and take into account the hazards listed on this material safety data sheet.

    Personal Protective Equipment

    Get yourself a PPE that will address both the chemical and airborne particulate hazards. To protect yourself against fumes, vapors, dust, or gases, use a NIOSH-approved full-face N95 respirator. If you belong to the European states, follow the EU regulations. An excellent self-contained breathing gear will not only give a snug facial fit but also filter and block the airborne particles.

    Other important things to put on include gloves, closed footwear, full-sleeved clothing, and a face mask.

    Engineering Controls

    Equip your laboratory with air cleaning devices, a fume hood, fans, and exhaust ventilation. These instruments will blow the airborne contaminants away from you and replace the air with fresh circulation.Additionally, install a handy safety shower and an eye bath for convenience when administering emergency response. Other apparatuses to put in place are extinguished and a chemical incinerator for safe elimination of hazardous chemicals.

    GHS Precautionary Statements

    When working with 3-Amino-6-chloropyridine-2-carboxamide, refer to P280, P271, P270, P264, P261, P260, and P233.Either use the product in a place with adequate aeration or work from outside. If in a room, make sure to do all the experiments in a fume hood, which will effectively manage the fumes produced.The most common but significant rule is to cover the body with the right equipment appropriately.

    After using 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    Take into account the personal hygienic measures like washing the hands and laundering the used clothing.Collect the gloves, empty chemical vessels, and the used products in a closed container, ready for elimination.Thoroughly clean the workspace with or without spillages so that you’re geared up for the next experiment.

    Storage of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    Store this product in closed, airtight, and sealed vessels.Keep it locked away from children, pets, and any other unauthorized persons. The perfect storage temperature is below -20°C, in a freezer. However, you can still set the temperatures between 2 – 8°C if you plan to store the chemical for more extended periods.

    First Aid Measures

    Inhalation

    Rush the victim to an aerated location.Check on the pulse rate, wheezing sound, shortness of breath, unconsciousness, and breathing difficulties. If the person exhibits these symptoms, administer oxygen support and seek further medical assistance.

    Body Contact

    Skin

    If 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) splashes on your body, take 15 minutes to brush it off with copious amounts of water and some mild soap. If you had clothes on, take them off before rinsing the area. After dealing carrying out this emergency procedure, wash the soiled clothing.

    Eyes

    Being a sensitive part, the eye is likely to be damaged when first aid response is delayed. Clean it with some clean running water for not less than 15 minutes. Ensure to keep the eyes open throughout the process.Seek the attention of an eye expert in case you feel uncomfortable.

    Ingestion

    Never attempt oral administration to an unconscious victim. Besides, it is inadvisable to induce vomiting unless with medical instructions. Rinse the mouth thoroughly for about 15 minutes. You can also drink at least half a liter of milk or water. Due to the possibility of acute toxicity in the GIT tract, seek assistance from a medic. Carry this data sheet and the chemical’s label with you, as reference samples.

    Fire Control

    During a fire outbreak, 3-Amino-6-chloropyridine-2-carboxamide will undergo thermal decomposition and generate toxic and irritating gases.Therefore, it is in order for the user to wear an approved respirator and other protective gears. Put the fire out using a chemical foam, powder, carbon dioxide, or water spray.

    Accidental Release Measures

    Contain any leaks and spills to prevent them from being emitted to the environment.Sweep up the powdery spillages without creating dust. If in liquid form, an inert absorbent like vermiculite will readily absorb the substance. Wash the workspace, vacuum, and ventilate it accordingly.

    Stability of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)

    3-Amino-6-chloropyridine-2-carboxamide is incompatible with oxidizing agents, sparks, heat, water, moisture, and flames.These conditions may initiate a reaction and subsequent product decomposition. The products evolved include oxides of nitrogen, hydrogen chloride, carbon monoxide, and carbon dioxide.

    175358-01-7 Chemical Disposal

    Every chemical should be disposed of according to their classification, as listed in the US EPA guidelines.

    Consult the local authorities to get a recommendation on the nearby licensed waste management companies. You can also use a chemical incinerator to get rid of the product.

    Shipping Information

    There are no special means of shipping 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7). It is non-hazardous for all modes of transport.

    Regulatory Info

    The manufacture, packaging conditions, and the use of 3-Amino-6-chloropyridine-2-carboxamide (175358-01-7)do not violate any federal or international chemical regulations. However, make sure to abide by the rules governing your local area.

    The product is strictly for research and not for therapeutic use.

    Technical Details

    At APICMO, we are always geared up for scientific exploration. For this reason, our scientists major in material and life sciences, chemical analysis and synthesis, chromatography, and drug discovery.

    3-Amino-6-chloropyridine-2-carboxamide (175358-01-7) Bulk Ordering and Pricing

    Does research and development in the science world fascinate you?If so, check in with our customer service, make a free registration, get the quotation, and make an order.

    Bibliography

    1. Suschitzky, Springer Science & Business Media, Polychloroaromatic Compounds 6 Dec 2012, Science, page 20-26.
    2. A. Abramovitch, John Wiley & Sons, Pyridine and Its Derivatives, Supplement 17 Sep 2009, Science , page 1002-1005.
    3. National Centre For Biotechnology Information, US. National Library Of Medicine, PubChem, 3-Amino-6-chloropyridine-2-carboxamide, Sections 1-9.
  2. Rated 5 out of 5

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    The best 3-Amino-6-chloropyridine-2-carboxamide and service i have ever had,Nice experience

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