7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)

(2 customer reviews)

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Description

7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) video

 

7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) product specifications

Purity 98%
Physical state Powder
Monoisotopic mass g/mol 257.92
Molecular weightg/mol 259.487
Molecular formula C8H4BrCIN2O
Melting point (˚C) >300
IUPAC name 7-bromo-6-chloro-1H-quinazolin-4-one
Density (g/cm3) 2.0+/-0.1
Chemical name · CHLOROQUINAZOLIN-4(3H)-ONE

· 6-Chloro-7-bromo-3H-quinazolin-4-one

· 7-bromo-6-chloro-3

CAS no 17518-98-8
Boiling point 481.8+/-35 at 760 mmHg

 


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2 reviews for 7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)

  1. APICMO

    Are you interested in purchasing any chemical without having to endure great hustle during the ordering, transport and delivery process? Worry no more; APICMO is a pharmaceutical manufacturing company that produce high-quality chemical compounds at an affordable price. We manufacture a wide range of chemical compounds including 7-Bromo-6-chloro-3H-quinazolin-4-one according to the Common Good Manufacturing Practice (CGMP) and other manufacturing regulations. Buy from us today and experience our extraordinary services!

    The chemical structure for 7-Bromo-6-chloro-3H-quinazolin-4-one

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)-APICMO

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) synthesis route

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)

    Precursor and downstream products

    Precursor

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)

    Downstream products

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) synonyms

    • 4(1H)-Quinazolinone, 7-bromo-6-chloro
    • 7-bromo-6-chloroquinazolin-4(1H)-one
    • 7-bromo-6-chloro1H-quinazolin-4-one
    • 7-bromo-6-chloro-3,4-dihydroquinazolin-4-
    • 6-Chloro-7-bromo-3H-quinazolin-4-one
    • 7-BROMO-6-CHLOROQUINAZOLIN-4(3H)-
    • 7-Bromo-6-Chloro-4(3H)-Quinazolinone
    • 7-BROMO-6-CHLORO-4-QUINAZOLINONE
    • 17518-98-8

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) physical and chemical properties

    Appearance

    It is a powder that has an off-white to whitecolor.

    Bonding

    Hydrogen Bond Donor-1

    Acceptor-1

    Rotatable Bond 0
    Covalent Bond 1

    Stability.

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) is stable under recommended storage conditions. Under high temperatures, it decomposes to produce carbon dioxide, nitrogen oxides(NOx), Hydrogen chloride gas.

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) Computed Properties

    Property Name Property Value
    Isotope Atom Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Heavy Atom Count 13
    Formal Charge 0
    Compound Is Canonized True
    XLogP3 2.1
    Exact Mass 257.92 g/mol
    Topological Polar Surface Area 41.5 A^2
    CACTVS Substructure Key Fingerprint AAADcYBzIAAEEAAAAAAAAAAAAAAAAAAAAAAwQ
    AAAAAAAAACBAAAAHgJQAAABrAqBmCQxwILAAAC
    oAiVTdACCAAEIBwQBilEIZugllDrB3pGEIYhgkABly9c
    YiACOAgBAIAECAAIEAIBAAgQABAAAAAAAAA==
    Complexity 259

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) uses

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) is an essential intermediate in the manufacture of the anticoccidial drug (coccidiostat) halofuginone (Tempostatin) that:

    • It Is used in veterinary medicine.
    • It is used as an anti-inflammatory and anti-fibrotic.
    • It is used as an inhibitorof collagen type 1 gene expression and may, therefore, inhibit tumor cell growth.
    • It hinders the development of T helper 17 cells. These are immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.
    • It also aids in the treatment of autoimmune disorders.

    Hazards associated with 7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)APICMO hazard icons

    • It may cause severe eye irritation or damage once it splashes to the eyes. Its symptoms may be eye reddening, eye-wateringand pain.
    • It may cause skin irritation once it gets in contact with the skin. Its symptoms may be skin rash, itching, reddening.
    • It may cause respiratory irritation once you breathe it. Its symptoms may include coughing, choking, dizziness and disorientation.
    • It is very toxic if swallowed.

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) safety measures

    1. Personal protection

    Ensure that you have the following protective gear:

    • Wear impervious clothing to protect your body from contact with the chemical.The amount of chemical you are handling and its concentration will determine the type of protective garment that you will wear.
    • Safety glasses that have side shields conforming to EN166.You should use eye protection equipment that is approved under appropriate standards I e. EN 166 (EU).
    • Wear gloves to protect your hands. Ensure that you inspect them before using to ensure that they do not have any tears that the chemical may pass through. While removing the gloves, use the proper glove removal technique without touching the outer surface to avoid skin contact with the chemical. After use, dispose of the gloves properly according to appropriate hygiene regulations. You can then wash your hands and dry them. You should choose gloves that satisfy EU Directive 89/686/EEC specifications and the standard EN 374.
    • To prevent yourself from inhaling the substance use type P95 (US) or type P1 (EU EN 143) particle respirator. If you need better protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges that are more effective. Use recommended respirators that are proven and tested under appropriate standards.

    2. Engineering controls

    • Ensure that there are fume hoods that are biologically safein the area that you are working on to reduce the accumulation of fumes and gas.
    • Ensure you install ventilation systems in the working area in case there is no sufficient air supply in the room.
    • Install biosafety cabinets that will help avoid accidents as you undertake your operations.

    3. First aid measures

    INHALATION

    If breathed in, you should move the person immediately to an open place that has fresh air. Let them sit in a comfortable position that will allow them to breathe without difficulty. If the victim is not breathing, give them artificial respiration and seek the attention of a doctor.

    SKIN CONTACT

    If the substance gets to your skin, remove any clothes that may be contaminated. Wash off the chemical with a gentle soap and a lot of water. In case irritation persists, seek the advice of a doctor.

    INGESTION

    In case it gets to your mouth, flush it with water. Avoid giving anything by mouth to an unconscious person. Consult a physician.

    EYE CONTACT

    If it gets to your eyes, rinse them with plenty of water. Remove eye contacts if you are wearing any. Flush the water for a minimum of 15 minutes not forgetting to clean both the upper and lower eyelids. See a physician.

    4. When using 7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)

    Conform to all proper hygiene measures regarding the use of chemicals. You should ensure that you do not breathe vapor, dust, mist or gas as it may be an irritant. Ensure that there is proper ventilation in the area that you are working on to get rid of the hazardous gases. When using this chemical, you must be in your protective gear to protect yourself from exposure. Avoid eating, drinking, and smoking as it may lead to ingestion and inhaling the substance. Ensure that there are safety showers and eyewash nearbyto prepare you in the event of an accident. Spillage equipment should also be available to contain any spill that occurs. Ensure all containers you are using are well labeled for easier identification and to prevent you from mixing the substance with incompatible substances.

    5. After using 7-Bromo-6-chloro-3H-quinazolin-4-one

    Once you are done using the product, remove the protective gear and wash it before wearing it again or discarding as it might be a hazard. Clean your hands after you are done using the product even if you had worn gloves. Clean the work surface after every shift of work to reduce the occurrence of a reaction. Dispose of all the containers and substance properly.

    6. When out of use

    Do not place the one chemical on bench tops, set in its storage cabinet to prevent spillage. Ensure that you keep the containers tightly sealed. All the containers should be labeled and placed in a cool and safe place where unauthorized personnel cannot access them.Ensure that there is sufficient ventilation and the containersplaced far from incompatible substances.

     

    7. 7-Bromo-6-chloro-3H-quinazolin-4-one handling and storage

    HANDLING

    Follow all the rules, good industrial hygiene and safety practice. Ensure that you wear all the protective garments in order prevent your eyes and skin from coming into contact with the chemical. Washyour hands before taking a break and at the end of every work day. Do not let this chemical get into drains as it is a contaminant and may be a hazard. Avoid formation of aerosols and dust that may be irritants. Ensure that there are adequate exhaustventilation systems to contain all the fumes and gas produced.

    STORAGE

    Use a desiccator filled with inert gas (nitrogen or argon) to store the chemical because it is hygroscopic (absorbs moisture). You could also use a glove box.Store the desiccator away from those containing incompatible substances. The desiccator should be completely sealed to prevent water vapor from getting in. They should also be placed in a dry area that is well ventilated. Ensure that the product gets sufficient security to prevent it from access to unauthorized personnel. Always keep all substances well labeled.

    8. 7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) accidental measures

    SPILLING

    If any spillage occurs, scoop the product and place it in a disposal container without creating dust. You should sweep it all and make sure that you have transferred it to the disposal containers. Tightly seal the disposal containers ready for disposal.

    FIRE CONTROL

    In the event of a fire, use any of the following extinguishing media:

    • Dry chemical/ Carbon dioxide
    • Alcohol-resistant foam
    • Water spray

    Hazardous fumes,i.e., Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas,are produced,andfirefighters are therefore advised to wear self-contained breathing apparatus if it is necessary.

    9. Sensitivity and reactivity

    Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) is hygroscopic and therefore reacts with water. It is incompatible with:

    • Acids
    • Acid Chlorides
    • Acid anhydrides
    • Oxidising agents

    Avoid moisture while handling this product.

    10. Chemical disposal

    • You can burn the waste in a chemical incinerator that has an afterburner and a scrubber. Take a lot of caution while igniting because this product is highly flammable.
    • You could also contact a licensed chemical waste disposal company to dispose of the material for you.
    • If the packaging of the chemical is contaminated,pleasedisposeofas an unused product.

    11. Shipping Information

    This product is safe for both air and road transport.

    7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8) Bulk ordering and pricing

    Contact us for any ordering or pricing inquiries and get to enjoy the best deals around the globe today.

    Bibliography

    1. Advances in Heterocyclic Chemistry, Volume 104, edited by Alan R. Katritzky, page 482.
    2. Pitt, M. J. In Bretherick’s Handbook of Reactive Chemical Hazards 6thed; Urben, P. G. Ed; Butterworth-Heinemann Ltd: Oxford, 1999; Vol.2, pp307-312.
    3. Quinazolines, Supplement 1, By Desmond J Brown, page 253.
  2. Apicmo

    The best 7-Bromo-6-chloro-3H-quinazolin-4-one and service i have ever had,Nice experience

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