Oxa-6-azaspiro[3.3]heptane (174-78-7)

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The ability to produce, synthesize and manufacture large quantities of Oxa-6-azaspiro[3.3]heptane (174-78-7) with quality control system under CGMP manufacturing
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Description

Oxa-6-azaspiro[3.3]heptane (174-78-7) video

Synthesis of the bicyclic spiro compound 2-oxa-6-azaspiro[3.3]heptane is presented. which this compound is often isolated as an oxalate salt, its isolation as a sulfonic acid salt yields a more stable and more soluble product. With these improved properties access to a wider range of reaction conditions with the spirobicyclic 2-oxa-6-azaspiro[3.3]heptane has been enabled.

1,3-Dipolar cycloaddition of benzylidenecyclopropane with various aldonitrones proceeds regioselectively giving good yields of 4-spirocyclopropane isoxazolidines. In the case of aldonitrones, bearing carbamoyl- or aryl-groups on the carbon atom, only the cis-isomer is formed. The compounds synthesized were tested for their virus-inhibiting activity.

Its chemecial description is: 2-oxa-6-azaspiro[3.3]heptane; 174-78-7; 2-oxa-6-aza-spiro[3.3]heptane; 2-oxa-6-azaspiro[3.3]heptane HCl; AC1Q1IDW; Spiro[oxetane-3,3′-azetidine]

Oxa-6-azaspiro[3.3]heptaneis a  useful synthetic intermediate in the preparation of epidermal growth factors, and it is insoluble in water.

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Oxa-6-azaspiro[3.3]heptane (174-78-7) Specifications

CAS 174-78-7
CAS Min % 97.0
CAS Max % 99.0
MDL Number MFCD12407093
InChI Key HPJALMWOZYIZGE-UHFFFAOYSA-N
Chemical Name or Material 2-Oxa-6-azaspiro[3.3]heptane
Infrared Spectrum N/A
Assay Percent Range 95%
Physical Form Clear Liquid at 20°C
Packaging Glass bottle
Molecular Formula C5H9NO
Molecular Weight (g/mol) 99.133
SMILES C1C2(CN1)COC2
Color Colorless-Very Pale Yellow at 20°C
Bolling Point 165.7 °C at 760 mmHg
Assay ≥98.0% (GC)

Oxa-6-azaspiro[3.3]heptane (174-78-7) Safety and HandlingAPICMO hazard icons

Oxa-6-azaspiro[3.3]heptane Hazard description:

w Causes serious eye irritation.

w Causes skin irritation.

w May cause respiratory irritation.

Avoid breathing dust/fume/gas/mist/vapors/spray.

(174-78-7) Precautionary statement:

w Avoid breathing dust/fume/gas/mist/vapors/spray.

w Wear protective gloves/protective clothing/eye protection/face protection.

w IF ON SKIN: Wash with plenty of soap and water.

w IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

w IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.

w IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

w Call a POISON CENTER or doctor/physician if you feel unwell.

Specific treatment (see relevant procedures. on this label).

w Rinse mouth.

w If skin irritation occurs: Get medical advice/ attention.

w If eye irritation persists: Get medical advice/attention.

w Remove victim to fresh air and keep at rest in a position comfortable for breathing.

w Take off contaminated clothing and wash before reuse.

w Store in a well-ventilated place.

w Store in a well-ventilated place. Keep container tightly closed.

w Store locked up.

w Dispose of contents/container to in accordance with local regulation .

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Articles

Regio- and diastereoselectivity of the cycloaddition of aldonitrones with

benzylidenecyclopropane: An experimental and theoretical study

Tetrahedron 2017 vol. 73 # 21 p. 3025 – 3030

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

Synthesis (Germany) 2017 vol. 49 # 11 p. 2394 – 2401

Oxa-6-azaspiro[3.3]heptane (174-78-7) Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Oxa-6-azaspiro[3.3]heptane (174-78-7) Bulk Ordering & Pricing:

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2 reviews for Oxa-6-azaspiro[3.3]heptane (174-78-7)

  1. APICMO

    Could you be looking for a chemical synthesizing company? At Apicmo, we synthesize and produce chemicals using the latest technology and high-class knowledge to ensure that what you want is what you get. 2-Oxa-6-azaspiro[3.3]heptanes is among the products that we are proud of as it has been manufactured to meet the requirements of the CGMP manufacturing regulations and their quality control system.

    2-Oxa-6-azaspiro[3.3]heptanes description

    To synthesize this product, the process starts with the isolation of an oxalate salt which is isolated as a sulfonic acid salt, yielding a more stable and soluble product. These properties allow for a wide range of reactions with 2-oxa-6-azaspiro [3.3]heptanes.

    1,3-Dipolar cycloaddition of benzylidenecyclopropane with several aldonitrones continues regioselectively providing high yields of 4-spirocyclopropane isoxazolidines. In the case of aldonitrones, bearing carbamoyl- or aryl-groups on the carbon atom, only the cis-isomer is formed. The compounds synthesized were tested for their virus-inhibiting activity.

    2-oxa-6-azaspiro [3.3] heptanes is available in APICMO contract, and therefore you can make an order by contacting our customer service.

    2-oxa-6-azaspiro [3.3] heptanes applications

    • This chemical is useful in the preparation of epidermal growth factors.

    2-oxa-6-azaspiro[3.3]heptanes chemical structure

    Oxa-6-azaspiro[3.3]heptane (174-78-7)

    2-oxa-6-azaspiro[3.3]heptanes (174-78-7) product specification

    CAS NO 174-78-7
    Chemical name 2-Oxa-6-azaspiro[3.3]heptanes
    Flash point (°C) 51.18
    Boiling point (˚C) 165.7 at 760 mmHg
    Molecular formula C5H9NO
    Molecular weight (g/mol) 99.133
    Monoisotopic mass (g/mol) 99.068
    Physical state Powder
    Purity 98%
    Density 1.12
    Structural formula Oxa-6-azaspiro[3.3]heptane (174-78-7)
    IUPAC name 2-oxa-6-azaspiro[3.3]heptanes
    Synonyms 2-oxa-6-azaspiro[3.3]heptanes
    2-OXA-6-AZASPIRO[3.3]HEPTANE HCL
    2-oxa-6-azaspiro[3.3]heptanes oxalate
    2-oxa-6-azaspiro[3.3]heptanes (ForM: oxalate)
    2-oxa-6-azaspiro[3,3]heptanes oxalic acid salt
    -Oxa-6-aza-spiro[3.3]heptane oxalic acid salt

    2-oxa-6-azaspiro[3.3]heptanes (174-78-7) chemical and physical properties

    The chemical is insoluble in water

    174-78-7 bonding

    Hydrogen bond donor count 1
    Rotatable bond count 0
    Hydrogen bond acceptor count 2

    174-78-7 appearance

    It is an off-white powder

    2-oxa-6-azaspiro[3.3]heptanes computed properties

    Covalently-bonded unit count 1
    Undefined Bond Stereocenter Count 0
    Isotope Atom Count 0
    Undefined Atom Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Defined Atom Stereocenter Count 0
    Heavy Atom Count 7
    Formal Charge 0
    Compound Is Canonicalized True
    XLogP3-AA -0.7
    Topological Polar Surface Are 21.3 A^2
    Complexity 82.1

    2-oxa-6-azaspiro[3.3]heptanes synthesize route

    This product has two synthesize routes

    Oxa-6-azaspiro[3.3]heptane (174-78-7)

    2-oxa-6-azaspiro[3.3]heptanes precursor and downstream products

    Oxa-6-azaspiro[3.3]heptane (174-78-7)

    2-oxa-6-azaspiro[3.3]heptanes use

    This product is used in the preparation of epidermal growth factors.

    Hazards associated with 2-oxa-6-azaspiro[3.3]heptanes (174-78-7)

    GHS classification symbol

    APICMO hazard icons

    • The chemical is highly flammable
    • It causes skin irritation and allergies such as soreness and redness
    • Could lead to eye irritation which could lead to permanent damage if not addressed
    • It could lead to respiratory irritation
    • In a case of ingestion, it could lead to vomiting or diarrhea

    2-oxa-6-azaspiro[3.3]heptanes safety measure

    Personal protection

    Always ensure that you have put on appropriate protective gears before handling this product. These include heavy gloves, a high-tech face mask equipped with an air purifier, protective glasses, and proper footwear. This will ensure that the chemical does not get to your eyes, mouth and that you do not inhale it accidentally.

    1. 2-oxa-6-azaspiro[3.3]heptanes engineering controls

    The laboratory should be well-equipped with emergency safety measures. It should be well ventilated, equipped with a fire extinguisher, safety showers, taps with running water and air cleaning devices.

    2. First aid measures

    In case of accidental contact with this chemical, ensure to take the following immediate measures;

    • Accidental inhalation

    The victim should be taken to an open or well-ventilated area to get enough fresh air. If s/he is having breathing problems, administer artificial oxygen and if this fails, get medical assistance.

    • When it comes to contact with your eyes

    Do not hesitate to rush to the tap and thoroughly rinse your eyes with clean water for about 15 minutes. If you have lenses on, ensure to remove them first for easier rinsing. Seek medical attention for further assurance.

    • Skin contact

    Rinse the affected area with clean water and a non-abrasive soap immediately for about ten to 1 minutes. If the clothes contact spillage too, remove them and put on clean clothes.

    • Accidental ingestion

    This product can be poisonous once it gets in the body system. You should, therefore, take immediate actions to avoid that the moment you accidentally get it in your mouth. Rinse your mouth thoroughly before taking half-liter of clean water. Note that you should not induce vomiting.

    3. 2-oxa-6-azaspiro[3.3]heptanes (174-78-7) storage

    The product is highly flammable, and you should, therefore, keep it away from any conditions that could lead to ignition. Store it in a ventilated area place ensuring that the container is tightly closed. The product should be kept in a cool, dry place and always use its original container for storage. Lock it in a safe place away from any unauthorized access.

    4. How to handle 2-oxa-6-azaspiro[3.3]heptanes (174-78-7)

    • When working with 174-78-7, consider taking the following measures;
    • Make sure you are working from a well-ventilated area with enough moving air
    • Put on protective gears such as gloves, masks, and glasses to prevent the chemical from getting into your eyes, skin or the respiratory tract.
    • Avoid inhaling its fumes, vapor or its dust

    5. Things to do after using 2-oxa-6-azaspiro[3.3]heptanes (174-78-7)

    • The first thing to do after you are done working with 2-oxa-6-azaspiro[3.3]heptanes (174-78-7) is to wash your hands
    • This should be followed with taking off the working clothes and taking a shower. Ensure to clean those clothes before the next use
    • Get rid of any empty containers and products residue following the regulations of your local and state regulation
    • Store the remaining product as per the regulations

    6. Accidental measures

    Regardless of how cautious you are when working with this product, accidents may occur. How do you deal with that?

    Fire

    In the event of fire outbreak, ensure that you have protective clothes on and safety equipment to help you put off the fire. You can use spray water, foam or dry powder. Avoid using products that could accelerate the fire.

    Spillage

    Use absorbent material to wipe the area before tossing it in a waste container. Do not forget to ventilate the area to get rid of the affected air. Use a vapor suppressor to minimize the vapors before washing the area with lots of water.

    7. 2-oxa-6-azaspiro[3.3]heptanes stability

    This chemical is very stable but only if handled under the ideal pressure and temperature. Avoid exposing it to strong acids and oxidizing agents to avoid decomposition.

    8. 2-oxa-6-azaspiro[3.3]heptanes (174-78-7) waste disposal

    You should treat this product as a special waste which you have to dispose accordingly ensuring that it does not and on the hands of unauthorized persons.

    9. 174-78-7 shipping info

    Being a stable product, 2-oxa-6-azaspiro[3.3]heptanes is not dangerous and can be transported in bulks.

    Regulatory information

    Always observe the local, federal and international rules and regulations in all stages when dealing with 2-oxa-6-azaspiro[3.3]heptanes.

    174-78-7 technical details

    Our technicians are experienced and versed with knowledge of chemical synthesis, life science, material science, and chemical analysis.

    2-oxa-6-azaspiro[3.3]heptanes (174-78-7) Bulk ordering and pricing

    This product is primarily meant for research, manufacturing and chemical development. If you need the chemical product for any of these reasons, do not hesitate to make an order from us and we will be glad to serve you.

    Bibliography

    1. National Centre For Biotechnology Information, US. National Library Of  Medicine, PubChem,2-oxa-6-azaspiro[3.3]heptanes, Sections 1-10
    2. Jochen Kuhlmann, A. Dalhoff, H.-J. Zeiler, Springer Science & Business Media, Quinolone Antibacterials, page 390-395.
    3. Patrick Bultinck, Hans De Winter, Wilfried Langenaeker, Jan P. Tollenare, CRC Press, Computational Medicinal Chemistry for Drug Discovery, page 1006-1010.
    4. Jie Jack Li, John Wiley & Sons, 2004, Name Reactions in Heterocyclic Chemistry, page 500-5007.

  2. Rated 5 out of 5

    Apicmo

    The best Oxa-6-azaspiro[3.3]heptane and service i have ever had,Nice experience

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