Oxa-6-azaspiro[3.3]heptane (174-78-7)

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Synthesis of the bicyclic spiro compound 2-oxa-6-azaspiro[3.3]heptane is presented. which this compound is often isolated as an oxalate salt, its isolation as a sulfonic acid salt yields a more stable and more soluble product. With these improved properties access to a wider range of reaction conditions with the spirobicyclic 2-oxa-6-azaspiro[3.3]heptane has been enabled.

1,3-Dipolar cycloaddition of benzylidenecyclopropane with various aldonitrones proceeds regioselectively giving good yields of 4-spirocyclopropane isoxazolidines. In the case of aldonitrones, bearing carbamoyl- or aryl-groups on the carbon atom, only the cis-isomer is formed. The compounds synthesized were tested for their virus-inhibiting activity.

Its chemecial description is: 2-oxa-6-azaspiro[3.3]heptane; 174-78-7; 2-oxa-6-aza-spiro[3.3]heptane; 2-oxa-6-azaspiro[3.3]heptane HCl; AC1Q1IDW; Spiro[oxetane-3,3′-azetidine]

Oxa-6-azaspiro[3.3]heptaneis a  useful synthetic intermediate in the preparation of epidermal growth factors, and it is insoluble in water.

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Oxa-6-azaspiro[3.3]heptane (174-78-7) Specifications

CAS 174-78-7
CAS Min % 97.0
CAS Max % 99.0
MDL Number MFCD12407093
Chemical Name or Material 2-Oxa-6-azaspiro[3.3]heptane
Infrared Spectrum N/A
Assay Percent Range 95%
Physical Form Clear Liquid at 20°C
Packaging Glass bottle
Molecular Formula C5H9NO
Molecular Weight (g/mol) 99.133
Color Colorless-Very Pale Yellow at 20°C
Bolling Point 165.7 °C at 760 mmHg
Assay ≥98.0% (GC)

Oxa-6-azaspiro[3.3]heptane (174-78-7) Safety and HandlingAPICMO hazard icons

Oxa-6-azaspiro[3.3]heptane Hazard description:

w Causes serious eye irritation.

w Causes skin irritation.

w May cause respiratory irritation.

Avoid breathing dust/fume/gas/mist/vapors/spray.

(174-78-7) Precautionary statement:

w Avoid breathing dust/fume/gas/mist/vapors/spray.

w Wear protective gloves/protective clothing/eye protection/face protection.

w IF ON SKIN: Wash with plenty of soap and water.

w IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

w IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.

w IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

w Call a POISON CENTER or doctor/physician if you feel unwell.

Specific treatment (see relevant procedures. on this label).

w Rinse mouth.

w If skin irritation occurs: Get medical advice/ attention.

w If eye irritation persists: Get medical advice/attention.

w Remove victim to fresh air and keep at rest in a position comfortable for breathing.

w Take off contaminated clothing and wash before reuse.

w Store in a well-ventilated place.

w Store in a well-ventilated place. Keep container tightly closed.

w Store locked up.

w Dispose of contents/container to in accordance with local regulation .

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.


Regio- and diastereoselectivity of the cycloaddition of aldonitrones with

benzylidenecyclopropane: An experimental and theoretical study

Tetrahedron 2017 vol. 73 # 21 p. 3025 – 3030

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

Synthesis (Germany) 2017 vol. 49 # 11 p. 2394 – 2401

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