[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0)

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The ability to produce, synthesize and manufacture large quantities of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) with quality control system under CGMP manufacturing

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[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) video

APICMO offers a wide range of A heterobifunctional, hydrophilic spacer products which includes [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid. It belongs to intermediates category. Contact us for more information.

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[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) Specifications

CAS 166108-71-0
CAS Min % 95%
CAS Max % 100%
MDL Number MFCD01321015
Chemical Name or Material (2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid
Infrared Spectrum Authentic
Physical Form Crystalline powder
Packaging Bag
Molecular Formula C21H23NO6
Molecular Weight (g/mol) 385.41
Color White
Melting Point 96-101 °C
Assay 95%

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) Safety and HandlingAPICMO hazard icons

(166108-71-0) GHS H Statement

No Data Available

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid GHS P Statement

No Data Available

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) Articles

Peptide PEGylation

Matthias Junkers

Aldrich ChemFiles 2007, 7.2, 15.

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) Bulk Ordering & Pricing:

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2 reviews for [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0)


    At APICMO, we are capable of producing, synthesizing and manufacturing large volumes of [2-]2(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0). We are keen to follow the CGMP manufacturing regulation guidelines on all our products.


     [2-[2(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0) Description 

    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is in the similar category as functionalized Oligoethylene Glycol, PEGylation and other related building blocks. The IUPAC Name of this product is 2-[2-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethoxy)ethoxy]acetic acid.


    [2-[2(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0)Product Specifications

     [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is also referred to as;

    • (2-[2-(9H-fluoren-9-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy)acetic acid.
    • 9-fluorennylmethoxycarbonyl-8-amino-3,6-dioxaoctanoic acid.
    • 8-fluorenylmethoxycarbomylamino-3,6-dioxaoctanoic acid.
    • 1-(9H-fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid.
    • RARECHEM EM WB 0032.


    Structural formula of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid

    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0)

    Chemical and Physical Properties of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid

    CAS NO 166108-71-0
    Molecular Formula C21H23HO6
    Molecular Weight (g/mol) 385.41
    Melting Point 96-101  degree Celsius
    Storage Temperature 0-8 degree Celsius.
    Purity 99%
    Boiling Point 631.4 degree Celsius at 760mmHg
    Density 1.265 g/cm3
    Monoisotopic mass 385.15253746


    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Appearance

    166108-71-0 comes in the form of white crystalline powder.



    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Stability


    Ideally, 166108-71-0 is stable when stored at the recommended conditions. Avoid exposure to extreme temperatures, heat, oxidizing agents and potential hazardous combustible products.

    Computed Properties for [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid.

    Property Name Property Value
    Exact Mass 385.153 g/mol
    Molar Refractivity 102.1702cm3
    Complexity 491
    Heavy Atom Count 28
    Isotope Atom Count 0
    Defined Atom Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Covalently-Bonded Unit Count 1
    Undefined Atom Stereocenter Count 0
    Monoisotopic Mass 385.153 g/mol
    Undefined Bond Stereocenter Count 0
    Polarizability 40.912766A3
    Refractive Index 1.579
    Topological polar surface area 94.1 A^2
    Formal charge 0
    Compound is Canonicalized Yes

    Synthesis Route for [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0).

    There are six routes in which 166108-71-0 may be synthesized.

    Recommended Synthesis Route for 166108-71-0

    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) (2)

    75001-08-0 2-[2-[2-(2-hydro…



    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) (2)

    166108-71-0 [2-[2-(Fmoc-amin…


    Other synthesis routes

    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid (166108-71-0) (2)

    [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0) Applications

    Being a heterobifunctional hydrophilicic spacer, 166108-71-0 is useful for the attachment of chromophores.


    Health Hazard Attributed to 166108-71-0.

    • Eye contact with this chemical may cause severe eye irritation.
    • If inhaled this product is harmful and may cause irritation to the respiratory tract system.
    • Direct contact with 166108-71-0 may cause irritation once absorbed by the skin.
    • Ingestion or swallowing of 166108-71-0 is harmful.


    Safety measures to take when handling [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0)


    1. Engineering Controls for 166108-71-0.

    • Keep the airborne levels below the allowed exposure limit by equipping your working area with local exhaust ventilation and also use process enclosures.
    • For operations that generate mist, dust or fumes always use ventilation to limit exposure to contaminants.
    • Remember to always wash your hands thoroughly after handling this product; especially before using lavatory, eating, smoking, before breaks and after a workday.

    2. First Aid Measures.

    • If inhaled

    Take the victim to an open area with adequate supply of fresh air or to a well-ventilated room. In case the breathing has stopped, try to resuscitate the casualty or use an artificial respirator. Consult a physician or a doctor as soon as you can.

    • For any contact with eyes.

    Rinse thoroughly and cautiously using copious amount of running water. Consult a doctor or physician for medical attention.

    • If swallowed or ingested.

    If conscious assist the victim to rinse the mouth with copious amount of water. For unconscious casualty you should never administer anything orally. Seek medical attention from a healthcare provider.

    • For direct contact with the skin.

    Wash off the chemical with plenty of running water and a mild soap. If irritation persists, consult your doctor or physician for medical advice or care.

    Always carry the safety data sheet provided with you whenever you seek for medical attention.

    3. Personal Protection and Safety.

    A full protection gear must be worn when handling this chemical, it should include;

    • A self-contained breathing apparatus which will prevent you from inhaling  the chemical.
    • Splash goggles will shield your eyes from any contact with 166108-71-0.
    • A full protective suit to cover you entire body may be worn; you also use a lab coat instead..
    • Gloves for your hands and boots for your foot should be worn.
    • A dust respirator is needed when dealing with this chemical
    • Consult a specialist for further directions before handling 166108-71-0.

    4. Ecological protection and safety.

    Neither 166108-71-0 nor its degradation products are toxic.

    5. Observe the Following When Using 166108-71-0.

    • Use a full protective suit or a lab coat.
    • Wear gloves to cover your hands and boots for your feet.
    • Use a dust respirator to avoid inhaling the dust.
    • Consider the help of a specialist before handling this product.

    6. When you are done Using 166108-71-0 ensure you.

    • Return the chemical to its original container while tightly closed.
    • Keep it in a locked place away from unauthorized access.
    • Ensure you store this chemical under the recommended storage conditions.

    7. When not Using 166108-71-0 observe the Following;

    • Keep it away from possible hazardous combustive products such as nitrogen oxides, nitrogen dioxides, carbon dioxides and carbon monoxides.
    • Keep it in a locked place away from access by unauthorized personnel.
    • Store it in a dry and place with adequate ventilation.


    1. [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0) Storage and Handling


    • Storage containers must always remain tightly closed.
    • Store away from possible hazardous combustive chemicals which are oxides of carbon and nitrogen.
    • Keep in a dry place with sufficient ventilation.


    • Consider consulting a professional or specialist before handling 166108-71-0.
    • Scrutinize the sheet data provided to be well informed on product hazards, fire and health.
    • Keep away from heat and any other source of ignition.
    • Avoid breathing the dust.

    8. Chemical Disposal

    When handling 166108-71-0, always follow the local, federal and state environmental control  guidelines in regard to disposing waste of this chemical.

    9. Sensitivity and Reactivity

    • 166108-71-0 is generally stable under the recommended storage conditions.
    • Avoid strong oxidizing agents and potential hazard combustive products.
    • Keep away from heat or any other source of ignition.

    10. Accidental Measures Required for 166108-71-0


    • For large leaks and spills, use a shovel to collect the waste into a waste disposal container.
    • For small leaks and spill, use the right tool and collect the waste into a waste disposal container.

    Fire Fighting Measures

    • For a large fire caused by 166108-71-0,use fog, foam or water spray; Never use a water jet to extinguish the fire.
    • For small fires resulting from 166108-71-0, use dry chemical or carbon dioxide to put off the fire.

    11. [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, (166108-71-0) Regulatory Info

    • 161608-71-0 is not subject to reporting requirements established by SARA Title III section 302.
    • The CAS No for this product does not exceed the reporting threshold levels set by SARA Title III, Section 313.
    • Have no known SARA hazards.
    • Have no known OSHA hazards.

    12. Shipping info for 166108-71-0

    166108-71-0 is safe for all modes of transport.

    13. Technical Service for 166108-71-0

    Our team of experts is experienced in all areas of life science, chemical synthesis, chromatography, material science and research analysis.

    14. Bulk Ordering and Pricing for 166108-71-0


    If you need to be supplied with large quantities of [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid for your research or development, contact the customer care and place your order.



    1. Journal of the American Chemical Society, , vol. 133, # 32 p. 12382 – 12385
    2. National Centre For Biotechnology Information, US. National Library of Medicine, Pubchem,5-Hydroxy-2-methylpyrimidine , Sections 1-7.
    3. Knut Rurack, Ramon Martinez-Manez, John Wiley & Sons, The Supramolecular Chemistry of Organic-Inorganic Hybrid Materials, page 700-702.



  2. Rated 5 out of 5


    The best [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid and service i have ever had,Nice experience

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