7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

(2 customer reviews)

This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) with quality control system under CGMP manufacturing
regulations.

Category:

Description

7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) video

Product Name 7-Benzyloxy-4-chloro-6-methoxyquinazoline
IUPACName 4-chloro-6-methoxy-7-phenylmethoxyquinazoline
Synonyms 1. 162364-72-9
364B729
4CH-012812
4-chloro-6-(methyloxy)-7-[(phenylmethyl)oxy]quinazoline
2. 4-chloro-6-methoxy-7-(phenylmethoxy)quinazoline
4-chloro-6-methoxy-7-(phenylmethoxy)-Quinazoline
3. 4-Chloro-6-methoxy-7-benzyloxyquinazoline
4-chloro-6-methoxy-7-phenylmethoxyquinazoline
4. 4-chloro-7-benzyloxy -6-methoxyquinazoline
5. 7-(benzyloxy)-4-chloro-6-methoxyquinazoline
7-benzyloxy4-chloro-6-methoxyquinazoline
7-benzyloxy-4chloro-6-methoxyquinazoline
7-benzyloxy-4-chloro6-methoxyquinazoline
7-benzyloxy-4-chloro-6methoxyquinazoline
6. 7-Benzyloxy-4-chloro-6-methoxyquinazoline
7. 7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE
A23000
AB0044107
AC-22776
ACN-036693
AJ-37957
AK-25065
AKOS005255349
AM807898
AN-2283
ANW-50637
AS-18141
AX8027687
B-2144
BCP14424
BR-25065
CJ-08962
CS-B0926
CTK4D1206
DTXSID50443221
EN000147
FT-0648419
HP21522
I06-1382
KB-199862
KB-72337
LBGIYCBNJBHZSZ-UHFFFAOYSA-N
MolPort-006-389-900
OR17604
PB14384
QC-1060
QUINAZOLINE, 4-CHLORO-6-METHOXY
7-(PHENYLMETHOXY)-
Quinazoline,4-chloro-6-methoxy-7-(phenylmethoxy)-
SBB066214
SC-53239
SCHEMBL297514
ST2419013
TC-067611
W3540
ZINC2527305
ZX-AT015432
Assay 98%
Smiles CC = NC = 2 (C1 = CC (OC) = C (C = 2) OCC3 (= CC = CC = C3)))
Molecular Formula C16H13ClN2O2
Inchi Key LBGYCBNJBHZSZ-UHFFFAOYSA-N
Inchi 1S/C16H13ClN2O2/c1-20-14-7-12-13(18-10-19-16(12)17)8-15(14)21-9-11-5-3-2-4-6-11/h2-8,10H,9H2,1H3
CAS Number 162364-72-9
CAS Min 95.0%
CAS Max 100.0%
Melting Point 132 ° C
Molecular Weight 300.74 g/mol.
Spared Spectrum Authentic

 


=

2 reviews for 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

  1. APICMO

    Have you been looking for a place to buy small or large quantities of 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)? There is no need to look anymore. We at APICMO have an answer for you. We have the expertise to synthesize and manufacture 7-Benzyloxy-4-chloro-6-methoxyquinazoline in small and large quantities. Our products satisfy the regulatory requirements of CGMP.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline is a product under the category of Quinazolines.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline Description

    The relationship between depending on the capacity of phosphodiesterase10A (PDE 10A) inhibitor PQ-10, comprising of 32 elements to determine the affinity of molecular configurations and their properties. We tested their functions which could be positron of tomography (PET) ligands, how they could prevent PDE 10A as well as other PDEs. We also performed their durability in vitro. The findings showed that quinazoline’s second part or alkyloxy in 60r 7 affects both the chemicals and their PDE10A choice. There is an increase in the selection of PDE10A by PDE3Aas a result of introducing methoxy group for molecules or quinazoline’ssixth stage molecules. In the substitution of 6, 7-difluoride in its area of quinoxaline, we found similar conclusions. Finally, the highest prevention prospective has been shown by the fluorinated(R) -7- (fluoromethoxy) -6-methoxy-4- (3- (quinoxalin-2-yloxy) pyrrolidine-1-yl) quinazoline (16 a), 19 ad, (R) – tert -butyl-3- (6-fluoroquinoxalin-2-yloxy) pyrrolidine-1-carboxylate (29), 35 (IC50 PDE10A 11-65 nM).

    Because of PQ-10, the metabolism stability improved by conversion of fluoloethoxy to 7% of quinazolines. In health improvement,   we have recognized PDE10A  as constructive18F vaccine development purposes for positron emission tomography. With the aid of QSAR researches, we have developed dental fluorinateddialkoxybiarylfibers and examined them as inhibitors of PDE10A. The 7-fluoromethoxy mixture is seen as an alternative for continual development.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline has 11 synthesis routes:

     7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    179688-01-8

    6-methoxy-7-phen…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    100-39-0

    benzyl bromide

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    61032-41-5

    methyl 4-(benzyl…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    3943-74-6

    methylvanilate

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    61032-42-6

    methuyl-2-amino-4…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    205259-40-1

    benzyl 5-methoxy…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    162364-79-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    121-34-6

    vanillic acid

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    27883-60-9

    methyl 4-hydroxy…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    205259-41-2

    benzyl 2-amino-5…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    91203-74-6

    benzyl 3-methoxy…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    126234-79-9

    4-chloro-6-metho…

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    56441-97-5

    methyl 4-(benzyl…

     

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-metho…

    Precursor products

    The product has 11 precursor products. They are as follows:

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    7-Benzyloxy-4-chloro-6-methoxyquinazoline chemical formula

    7-Benzyloxy-4-chloro-6-methoxyquinazoline(162364-72-9)

    7-Benzyloxy-4-chloro-6-methoxyquinazolineSpecifications

     

    Chemical and physical properties of 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    Bonding

    Covalent Bond 1-unit
    Rotatable Bond 4-units
    Hydrogen Bond Acceptor count- 4 units
    Donor count- none

    Appearance

    7-Benzyloxy-4-chloro-6-methoxyquinazoline appears as a white powder

    Computed properties of 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    Name Of The Property Value
    StereocenterCount of The Undefined Bond 0
    StereocenterCount of The Defined Bond 0
    StereocenterCount of The Undefined Atom 0
    StereocenterCount of The Defined Atom 0
    Heavy Atom Count 21
    Formal Charge 0
    CanonicalisedCompound True
    Xlogp3-AA 3.9
    Exact Mass 300.067 g/mol.
    MonoisotopicMass 300.067 g/mol.
    The Surface Area of Topological Mass 44.2 A^2
    CACTVS Substructure Key Fingerprint AAADccB7MAAEAAAAAAAAAAAAAAAAAAAAAAA8YI
    AAAAAAAACx9AAAHgIAAAAADA6hniY31vYIFACgAyRj
    ZACCiCkxJqAJ2CA+7piNLqLF+9uGPCruwBtK6Cew0D
    MOIEABAgACQABAgAIEAASAAAAAAAAAAA==
    Complexity 325
    Molecular Weight 300.742 g/mol.

    Uses of 162364-79-9

    • 7-Benzyloxy-4-chloro-6-methoxyquinazoline is useful in product synthesis, development,and research.
    • It is useful in the development of vaccines.

    Safety measures for handling 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    7-Benzyloxy-4-chloro-6-methoxyquinazolinemight be hazardous to your health if you mishandled it. You should therefore treat the chemical cautiously to prevent exposing yourself to some risks associated with it.

    Risks associated with 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    APICMO hazard icons

    This compound causes the following risks:

    GHS classification symbol

    • Skin irritation
    • Irritation on the eyes
    • Irritates the respiratory tract
    • The substance is hazardous if swallowed.

    Personal protection equipment

    It is important to protect your body when dealing with the compound to avoid subjecting your body to the above risks. As such, ensure you have the following protective equipment when working with 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    Skin protection

    Ensure you put on protective clothing that covers your entire body.

    Cover your hands with protective gloves.

    Eye and face protection

    Protect your eyes with safety goggles. Wear face shields to protect your face.

    Respiratory protection

    Respiratory protections such as approved respirators should be ready for emergencies.

    Ensure the respiratory protective equipment have particle filters.

    First aid measures

    Any time you are working with 7-Benzyloxy-4-chloro-6-methoxyquinazoline, emergencies may occur at any time. These emergencies may expose your body to the hazards associated with the compound. Administering first aid will help to prevent adverse reactions in your body. Here are some of the first aid measures that you should always consider under different occasions.

    In case of 7-Benzyloxy-4-chloro-6-methoxyquinazolineIngestion

    • Upon ingestion ofthe chemical,
    • Drink plenty of water immediately after swallowing. The water must be cold and lean
    • It is not advisable to instigate vomiting.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline inhalation

    In case of the breath of the compound,

    • Move the victim outdoors or a well-ventilated area.
    • Make sure that the victim can relax and breathe without any barriers.
    • Seek medic’s advice if irritation prolongs.

    In case of contact with the sin

    • Clear the particles from the site of contact.
    • Use the copious amount of cold, clean water to wash the contacted part of the body thoroughly.
    • If corrosion persists, seek help from a medic.

    Eye contact with 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    Use plenty of running cold water to bathe the eyes for about 10 minutes

    Take out eye contact lens if you have them.

    Seek medic’s assistance in case of persistent irritations.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline Handling Precautions

    1. When in use:

    When working with7-Benzyloxy-4-chloro-6-methoxyquinazoline, consider the following precautions.

    • Obtain the appropriate instructions.
    • Read the instruction comprehensively before you start working with the product.
    • Ensure proper ventilation of the working area.
    • Avoid inhalation of the dust.
    • Do not let the chemical get into contact with your body or eyes.
    • Use a place with proper ventilation or outdoors.
    • Do not discharge the chemical into drains or rivers.
    • Avoid working with the substance in squeezed areas.
    • Do not mix the chemical with combustibles.
    • Avoid subjecting the chemical to friction or grinding.
    • Do not deal with the substance while pregnant or nursing.
    • Avoid smoking, drinking or eating while dealing with the chemical.

    After use:

    • Clean your face and the hands thoroughly with cold water and soap.
    • Take out contaminated clothes and do not take them out of working place or reuse them before cleaning.
    • Cautiously remove the gloves avoiding touching the contaminated areas.
    • Dispose of the gloves as required by the federal or local laws.
    • Store the remaining substance in a storage bottle and tightly close it.
    • Clear the working bench and clean it.
    • Collect the waste and pack well in closed disposal containers.

    2. Storage of 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    • Use a well-labeledoriginal container to store the chemical. Cork the storage bottle tightly.
    • Ensure proper ventilation of the storage area.
    • Do not keep under sunlight or hot surfaces. The temperature should not exceed 50 °C/ 122 °F.
    • Do not expose the chemical to water or moist places.
    • Keep away from children and unauthorized persons.

    3. Accident control measures

    Firefighting control

    7-Benzyloxy-4-chloro-6-methoxyquinazoline or its secondary products may include rigger fire. If this happens while dealing with the product, here are some firefighting measures you should consider:

    • Put off the fire with appropriate fire extinguishing media. These include dry chemical powder,carbon dioxide or foam.
    • Fight the fire wearing protective clothing. This is to avoid getting into contact with eyes and skin.
    • Wear self-contained breathing equipment.
    • Fight the fire from a safe distance.
    • In case of major fires or explosions, do not fight the fire. Evacuate the site.

    Some of the harmful fumes resulting from 7-Benzyloxy-4-chloro-6-methoxyquinazoline combustion are hydrogen chloride (HCl), carbon (ii) oxide, carbon monoxide and hydrogen oxides (HOx).

    Spillages

    In case of accidental spillages, collect the waste and pack in labeled disposal containers. Dispose of the waste according to the dictates of the local and federal waste disposal regulations.

    4. Shipping

    Under normal conditions, there are no dangers associated with transportation of 7-Benzyloxy-4-chloro-6-methoxyquinazoline.

    5. Stability and reactivity

    7-Benzyloxy-4-chloro-6-methoxyquinazoline is stable under the normal condition.

    The compound reacts with strong acids and oxidizing agents. Also, avoid heating the chemical.

    6. Waste disposal measures

    Package the waste in an appropriate waste container and submit to a licensed disposal company.

    Follow the regulations put in place by the state or the federal laws.

    Regulatory information

    The prime purpose for 7-Benzyloxy-4-chloro-6-methoxyquinazolineis to be used in research and development. Those involved in handling it must, therefore, bewell-trained persons with experience in laboratory practices. Qualified supervisors should be available to oversee the usage of the chemical. The product ought to be handled with respect and care under the appropriate conditions. The product is not for human consumption. We believe that the information provided in this document is correct to the best of our knowledge. It is therefore useful as a guide in combination with other sources of information.

    Technical service

    To ensure that we offer you the quality and reliable services, our team of experts is committed to research and development in fields such as chemical science, chromatography, life science, analytical science among others.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline pricing and bulk ordering

    If you are looking for a place to order large quantities of 7-Benzyloxy-4-chloro-6-methoxyquinazoline, our friendly customer care is ever ready to hear from you. You can contact our customer care service and make your bulk orders for your product synthesis, development or research.

    Bibliography:

    1. Marcel Lindemann Sonja, HinzWinnie,  Deuther-Conrad, Barbara Wenzel, Radio synthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radio ligand for PET imaging of the adenosine A 2B receptor, page 2-5.
    2. Pitt, M. J. In Bretherick’s Handbook of Reactive Chemical Hazards 6thed; Urben, P. G. Ed; Butterworth-Heinemann Ltd: Oxford, 1999; Vol.2, pp301-310.
    3. National Centre For Biotechnology Information, US. National Library of Medicine, Pubchem, 4,4-Difluorocyclohexanone, Sections 1-8.
  2. Apicmo

    The best 7-Benzyloxy-4-chloro-6-methoxyquinazoline and service i have ever had,Nice experience

Add a review

Your email address will not be published.