2-Oxa-6-azaspiro[3.4]octane (1408075-00-2)
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Description
2-Oxa-6-azaspiro[3.4]octane (1408075-00-2) video
It was studied the design and synthesis of novel azaspirocycle or azetidine substituted 4-anilinoquinazoline derivatives. The EGFR inhibitory activities and in vitro antitumor potency of these newly synthesized compounds against two lung cancer cell lines HCC827 and A549 were evaluated. Find out that most of the target compounds possess good inhibitory potency. In particular, compounds 21g with 2-oxa-6-azaspiro[3.4]octane substituent was found to possess higher EGFR inhibitory activities and similar antitumor potency comparing to the lead compound gefitinib with improved water solubility.
In addition, piperazine and morpholine are common modules in drugs. Design and synthesis of their surrogates may help to explore the chemical in medicinal chemistry. Through [3+2] cycloaddition, the improved synthesis of 6-benzyl-2,6-diazaspiro[3.4]octane oxalate and 2-oxa-6-azaspiro[3.4]octane as substitutes of piperazine and morpholine was provided, respectively. Multi-gram quantities of the compounds could be easily obtained in relatively high yields.
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2-Oxa-6-azaspiro[3.4]octane (1408075-00-2) Specifications
CAS | 1408075-00-2 |
CAS Min % | 95.0 |
CAS Max % | 97.0 |
MDL Number | MFCD22123302 |
InChI Key | ZHAIMJRKJKQNQI-UHFFFAOYSA-N |
Chemical Name or Material | 2-Oxa-6-azaspiro[3.4]octane |
Infrared Spectrum | N/A |
Physical Form | N/A |
Packaging | Standard packing |
Molecular Formula | C6H11NO |
Molecular Weight (g/mol) | 113.16 g/mol |
SMILES | C1CNCC12COC2 |
Color | white |
Melting Point | N/A |
Assay | ≥97% |
2-Oxa-6-azaspiro[3.4]octane (1408075-00-2) Safety and Handling
2-Oxa-6-azaspiro[3.4]octane Hazard description:
w Causes skin irritation [Warning Skin corrosion/irritation]
w Causes serious eye irritation [Warning Serious eye damage/eye irritation]
w May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
(1408075-00-2) Precautionary statement:
w Avoid breathing dust/fume/gas/mist/vapors/spray.
w Wash … thoroughly after handling.
w Use only outdoors or in a well-ventilated area.
w Wear protective gloves/protective clothing/eye protection/face protection.
w IF ON SKIN:Wash with plenty of water.
w IF INHALED: Remove person to fresh air and keep comfortable for breathing.
w IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
w Call a POISON CENTER or doctor/… if you feel unwell.
w Specific treatment (see … on this label).
w IF SKIN irritation occurs:Get medical advice/attention.
w If eye irritation persists:Get medical advice/attention.
w Take off contaminated clothing.
w Store in a well-ventilated place. Keep container tightly closed.
w Store locked up.
w Dispose of contents/container to …
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
Articles
Synthesis of azaspiro[3.4]octanes via [3+2] cycloadditionWang
Through [3+2] cycloaddition, the improved synthesis of 6-benzyl-2,6-diazaspiro[3.4]octane oxalate and 2-oxa-6-azaspiro[3.4]octane as substitutes of piperazine and morpholine was provided, respectively…
Chinese Journal of Organic Chemistry 2015.
Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors
In particular, compounds 21g with 2-oxa-6-azaspiro[3.4]octane substituent was found to possess higher EGFR inhibitory activities and similar antitumor potency comparing to the lead compound gefitinib with improved water solubility…
Bioorganic and Medicinal Chemistry Letters 2013.
2-Oxa-6-azaspiro[3.4]octane (1408075-00-2) Technical Service:
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
2-Oxa-6-azaspiro[3.4]octane (1408075-00-2) Bulk Ordering & Pricing:
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APICMO –
We do lab scale to large-scale manufacture and synthesis of 2-Oxa-6-azaspiro[3.4]octane among other chemicals. At APICMO, our products conform to the CMGP manufacturing regulations.
Chemical structure of 2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2)
2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) Product specification
· 2-oxa-6-azaspiro[3.4]octane
· 2-oxa-7azaspiro[3.4]octane
· 2-oxa-6-azaspiro[3.4]octa…
2-Oxa-6-azaspiro[3.4]octane(1408075-00-2) Chemical and Physical Properties.
Appearance
It is a liquid with a colorless to pale yellow color.
Bonding
Acceptors-2
Stability
2-Oxa-6-azaspiro[3.4]octane is stable under recommended storage conditions. Decomposition will not occur if it is used and stored according to specifications. Decomposition products include Carbon monoxide, carbon dioxide, and Nitrogen Oxides.
2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) computed properties
2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) uses
It is involved in the preparation of aza-spirocycle or azetidine substituted 4-anilinoquinazoline derivatives, which exhibits epidermal growth factor receptor (EGFR) inhibitory activities. Also used for scientific development and research.
Hazards associated with 2-Oxa-6-azaspiro[3.4]octane.
Safety measures when dealing with 2-Oxa-6-azaspiro[3.4]octane
1. Personal protection.
Avoid direct skin contact by wearing chemical resistant clothing. Avoid direct eye contact too and wear protective gloves. Wear suitable respiratory equipment if handling 2-Oxa-6-azaspiro[3.4]octane in an area that is not well ventilated. You are recommended to use the following protective gear when using the chemical:
2. 2-Oxa-6-azaspiro[3.4] octane engineering control.
3. First aid measures.
Skin Contact
In case of any contact with the skin, carefully wash with a lot of running water and a gentle soap. You may use cold water. Cover the affected area with an emollient. Seek medical attention. Wash any contaminated clothing before reuse.
Eye Contact
In case it splashes in your eyes, quickly get rid of contact lens if wearing any. With the eyes wide open, rinse the eyes with cold, clean water for at least 15 minutes. You can use cold water. If the burning and redness persist, seek the attention of a physician.
Ingestion
You should not induce vomiting. Give water to the victim to drink. Contact a physician.
Inhalation
Exposure to 2-Oxa-6-azaspiro[3.4]octane may irritate the upper respiratory tract whose symptoms are coughing, sneezing and nasal irritation. Get the victim outside or to somewhere with fresh air. If the victim’s breathing is difficult, administer oxygen. Seek medical attention.
4. When using 2-Oxa-6-azaspiro[3.4]octane
While using it consider the following:
5. After using 2-Oxa-6-azaspiro[3.4]octane
6. When out of use
7. 2.Oxa-6-azaspiro[3.4]octane storage and handling
Storage
Handling
While handling, it is Important to:
8. 2-Oxa-6-azaspiro[3.4]octane Accidental Measures.
Fire control
The suitable extinguishing agents include: Carbon dioxide, extinguishing powder and water spray. If you are fighting more massive fires, use water spray or alcohol-resistant foam. Advice for firefighters:
Spillages
Avoid coming into contact with any leaked material. You can stop any further leak if it does not harm you. Contain the spill with the liquid binding material (sand, diatomite, sawdust). Deposit the absorbent used in a container that is well labeled ready for disposal. Flush spill area. For large spills that you may not be able to contain you could either contact the supplier or emergency services.
9. Sensitivity and Reactivity.
2-Oxa-6-azaspiro[3.4]octane reacts with strong oxidizing agents, strong acids, reducing agents and bases. It decomposes under high temperatures producing Carbon monoxide, Carbon dioxide, and Nitrogen Oxides.
10.Chemical Disposal.
You should treat 2-Oxa-6-azaspiro[3.4]octane as special waste under adherence to official regulations. It must, therefore, be managed, handled and disposed of carefully in a manner that complies with the area, federal or state regulations.
11. 2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) Shipping Info
2-Oxa-6-azaspiro[3.4] octane is safe for either ground or air transportation.
Regulatory Info
2-Oxa-6-azaspiro[3.4]octane conforms to all local, federal and state laws.
2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) Bulk ordering and pricing.
Are you interested in a small amount or bulk buying? Get in touch with us. At APICMO, we assure you of satisfactory quality and competitive price.
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