1 review for 2-Oxa-6-azaspiro[3.4]octane (1408075-00-2)

1. 

   APICMO – 12/10/2018

   We do lab scale to large-scale manufacture and synthesis of 2-Oxa-6-azaspiro[3.4]octane among other chemicals. At APICMO, our products conform to the CMGP manufacturing regulations.

   Chemical structure of 2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2)

   

   2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) Product specification

   Synonyms	· Hemioxalate salt · 2-oxa-6-azaspiro[3.4]octane · 2-oxa-7azaspiro[3.4]octane · 2-oxa-6-azaspiro[3.4]octa…
   Purity	95%
   Physical state	Liquid
   Monoisotopic mass (g/mol)	113.084
   Molecular weight (g/mol	113.16
   Molecular formula	C6H11NO
   Melting point (˚C)	140-149
   IUPAC name	2-oxa-7-azaspiro[3.4]octane
   Density (g/cm3)	1.08
   Chemical name	2-oxa-7-azaspiro[3.4]octane
   CAS no.	220290-68-6
   Boiling Point (˚C)	187

   2-Oxa-6-azaspiro[3.4]octane(1408075-00-2) Chemical and Physical Properties.

   Appearance

   It is a liquid with a colorless to pale yellow color.

   Bonding

   Covalent Bond	1 unit
   Hydrogen Bond	Donor-1 Acceptors-2
   Rotatable Bond	0 units

   Stability

   2-Oxa-6-azaspiro[3.4]octane is stable under recommended storage conditions. Decomposition will not occur if it is used and stored according to specifications. Decomposition products include Carbon monoxide, carbon dioxide, and Nitrogen Oxides.

   2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) computed properties

   Property Name	Property Value
   Isotope Atom Count	0
   Undefined Bond Stereocenter Unit	0
   Defined Bond Stereocenter Count	0
   Undefined Atom Stereocenter Count	0
   Defined Atom Stereocenter Count	0
   Heavy Atom Count	8
   Formal Charge	0
   Compound Is Canonilized	True
   XlogP3-AA	0.3
   Exact Mass	113.084 g/mol
   Monoisotopic Mass	113.084 g/mol
   Topological Polar Surface Area	21.3A^2
   Complexity	98.7
   Rotatable Bond Count	0
   Molecular weight	113g/mol

   2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) uses

   

   It is involved in the preparation of aza-spirocycle or azetidine substituted 4-anilinoquinazoline derivatives, which exhibits epidermal growth factor receptor (EGFR) inhibitory activities. Also used for scientific development and research.

   Hazards associated with 2-Oxa-6-azaspiro[3.4]octane.

   • It may cause skin irritation when in direct contact with the skin.
   • It may cause respiratory irritation if inhaled. It irritates the upper respiratory tract.
   • It causes severe eye irritation.
   • May be harmful by ingestion.
   • It is a combustible liquid.

   Safety measures when dealing with 2-Oxa-6-azaspiro[3.4]octane

   1. Personal protection.

   Avoid direct skin contact by wearing chemical resistant clothing. Avoid direct eye contact too and wear protective gloves. Wear suitable respiratory equipment if handling 2-Oxa-6-azaspiro[3.4]octane in an area that is not well ventilated. You are recommended to use the following protective gear when using the chemical:

   • Synthetic apron.
   • Gloves
   • Splash goggles.
   • Vapour respirator (if needed).
   • Facemask
   • Impervious boots.

   2. 2-Oxa-6-azaspiro[3.4] octane engineering control.

   • if general ventilation is not sufficient to control the amount of air supply in the room,  you can use local exhaust ventilation.
   • Use non-sparking ventilation systems, approved explosion-proof electrical systems.
   • Have eyewash and safety shower in case of contact or splash.

   3. First aid measures.

   Skin Contact

   In case of any contact with the skin, carefully wash with a lot of running water and a gentle soap. You may use cold water.  Cover the affected area with an emollient. Seek medical attention. Wash any contaminated clothing before reuse.

   Eye Contact

   In case it splashes in your eyes, quickly get rid of contact lens if wearing any. With the eyes wide open, rinse the eyes with cold, clean water for at least 15 minutes. You can use cold water. If the burning and redness persist, seek the attention of a physician.

   Ingestion

   You should not induce vomiting. Give water to the victim to drink. Contact a physician.

   Inhalation

   Exposure to 2-Oxa-6-azaspiro[3.4]octane may irritate the upper respiratory tract whose symptoms are coughing, sneezing and nasal irritation. Get the victim outside or to somewhere with fresh air. If the victim’s breathing is difficult, administer oxygen. Seek medical attention.

   4.  When using 2-Oxa-6-azaspiro[3.4]octane

   While using it consider the following:

   • Avoid breathing the fume/ vapor/mist.
   • After contact with skin, wash immediately.
   • Ensure sufficient ventilation during use.
   • Wear protective clothing and chemical resistant boots.
   • Avoid prolonged exposure.
   • Use caution while handling.
   • Do not inhale dust or vapor.
   • Use only in a chemical fume hood.
   • Eating, drinking or smoking is prohibited while using this product.
   • Have a safety shower and eye wash available.

   5. After using 2-Oxa-6-azaspiro[3.4]octane

   • Wash hands thoroughly after handling.
   • Dispose of contents or containers by the regulations.
   • Keep it tightly sealed.

   6. When out of use

   • Store locked up.
   • Store in cool, dry conditions.
   • Store in the original shipping container or a well-marked container.
   • Keep in a well-ventilated place.

   7. 2.Oxa-6-azaspiro[3.4]octane storage and handling

   Storage

   • Store in a dry area that has sufficient ventilation, temperature controlled, out of direct sunlight.
   • Follow all applicable health and safety regulations.
   • Keep away from unauthorized personnel.
   • Do not store it near heat or sources of fire.
   • Store it locked up in a container.
   • Keep away from incompatible chemicals, combustible and flammable materials heat, sparks, open flames, hot surfaces or oxidizing agents.
   • Store in a place that has no direct sunlight.

   Handling

   While handling, it is Important to:

   • Avoid any heat and ignition sources such as sparks, hot surfaces, and static discharge.
   • Work in an open or well-ventilated room.
   • Wear protective clothing to minimize inhaling the fumes, or getting the chemical in contact with skin or eyes.
   • Use ventilation systems that do not spark, approved explosion-proof equipment and intrinsically safe electrical systems.
   • Prevent the formation of aerosols.
   • Work in a fume chamber.

   8. 2-Oxa-6-azaspiro[3.4]octane Accidental Measures.

   Fire control

   The suitable extinguishing agents include: Carbon dioxide, extinguishing powder and water spray. If you are fighting more massive fires, use water spray or alcohol-resistant foam. Advice for firefighters:

   • Wear a self-contained respirator.
   • Wear a fully protective impervious suit.

   Spillages

   Avoid coming into contact with any leaked material. You can stop any further leak if it does not harm you. Contain the spill with the liquid binding material (sand, diatomite, sawdust). Deposit the absorbent used in a container that is well labeled ready for disposal. Flush spill area. For large spills that you may not be able to contain you could either contact the supplier or emergency services.

   9. Sensitivity and Reactivity.

   2-Oxa-6-azaspiro[3.4]octane reacts with strong oxidizing agents, strong acids, reducing agents and bases.  It decomposes under high temperatures producing Carbon monoxide, Carbon dioxide, and Nitrogen Oxides.

   10.Chemical Disposal.

   You should treat 2-Oxa-6-azaspiro[3.4]octane as special waste under adherence to official regulations. It must, therefore, be managed, handled and disposed of carefully in a manner that complies with the area, federal or state regulations.

   11. 2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) Shipping Info

   2-Oxa-6-azaspiro[3.4] octane is safe for either ground or air transportation.

   Regulatory Info

   2-Oxa-6-azaspiro[3.4]octane conforms to all local, federal and state laws.

   2-Oxa-6-azaspiro[3.4]octane ( 1408075-00-2) Bulk ordering and pricing.

   Are you interested in a small amount or bulk buying? Get in touch with us. At APICMO, we assure you of satisfactory quality and competitive price.

   Bibliography

   1. Ring Systems Handbook, Volume 1, American Chemical Society. Chemical Abstracts Service, American Chemical Society,2003, the University of California page 470-474
   2. Reactions and syntheses: -In the Organic Chemistry Laboratory, Lutz F. Tietze, TheophilEicher, Ulf  Diederichsen, Nina Schutzenmeister, Andreas Speicher, Page 258-270.
   3. Intermediate Chemistry, Third Edition, Ann M. Fabirkiewicz, John C. Stowell, Page 25-30

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