Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate (136790-77-7)

The ability to produce, synthesize and manufacture large quantities of Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate (136790-77-7) with quality control system under CGMP manufacturing regulations.

SKU: 136790-77-7 Category:

Description

Lubiprostone Heptanoate CAS number is 136790-77-7 which is a senior intermediate of Lubiprostone, the synthesis is very difficult. There are three ways to synthesize Lubiprostone Heptanoate, the first is to use p-phenylbenzoylcolicide as raw material, synthesize the fluorine-containing lower side chain and then synthesize the carboxyl group-containing upper side chain The used reagent is methyl ester. The second is based on the coriolide protection base as the starting material, let its hydroxyl was protected by Dihydropyran, the use of the upper side chain is acid, and the lower side chain does not protect the hydroxyl group. The above step of two ways are longer and the upper side of the chain is expensive, and use the toxic reagents ethanol thallium. The third is based on (-) coriolide as raw material, dissolved in DMF, followed by adding imidazole and DMF solution containing tert-butyl dimethyl chlorosilane, through the reaction to selectively protect the primary hydroxyl. This idea owns low price of starting material, low toxicity of the use of reagents,good, safety, the reaction step is shorter than the before two ideas.

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Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate (136790-77-7) Specifications

CAS 136790-77-7
CAS Min % 95%
CAS Max % 100%
MDL Number No Data Available
InChI Key No Data Available
Chemical Name or Material Lubiprostone Intermediate ≥98%Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate16,16-difluoro-9,15-dihydroxy-11-[(tetrahydro-2H-pyran-
Infrared Spectrum No Data Available
Physical Form Viscous oily solid
Packaging Glass bottle
Molecular Formula C32H48F2O6
Molecular Weight (g/mol) 566.72
SMILES No Data Available
Color Yellowish
Melting Point No Data Available
Assay 98%

Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate (136790-77-7) Safety and HandlingAPICMO hazard icons

(136790-77-7) GHS H Statement

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Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate GHS P Statement

No Data Available.

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Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate (136790-77-7) Articles

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Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate (136790-77-7) Bulk Ordering & Pricing:

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