Description

Tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride, its pharmaceutically acceptable salt, ester, solvate thereof , are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.

Its chemical names that tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride, tert-butyl-2,7-diazaspiro[3,5]nonane-7-carboxylate hydrochloride, tert-butyl 2,7-diazaspiro[3.5]nonan-7-carboxylate hydrochloride, tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate, 2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester hydrochloride.

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tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9) Specifications

CAS	1023301-84-9
CAS Min %	97.0
CAS Max %	98.0
MDL Number	MFCD13185086
InChI Key	HVLQURGQQISYSQ-UHFFFAOYSA-N
Chemical Name or Material	tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride
Infrared Spectrum	N/A
Physical Form	Of-white to beige powder
Packaging	Glass bottle
Molecular Formula	C12H23ClN2O2
Molecular Weight (g/mol)	261.76828
SMILES	Cl.O=C(OC(C)(C)C)N2(CCC1(CNC1)(CC2))
Color	beige
Melting Point	50.1 – 158 °C
Assay	≧98%

tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9) Safety and Handling

tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride Hazard description:

w May cause an allergic skin reaction

w Causes serious eye irritation

1023301-84-9 Precautionary statement:

w Avoid breathing dust/fume/gas/mist/vapours/spray.

w Wear protective gloves and eye/face protection.

w IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

w IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.

w Store locked up.

w Dispose of contents/container in accordance with local/regional/national/

international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

Articles

SUBSTITUTED PIPERIDINE COMPOUNDS

Piperidine compounds acceptable salts and solvates thereof in the pharmaceutically, are especially useful for treating cancer.

WO2016/40515, 2016

tert-Butyl2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride (1023301-84-9) Technical Service:

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