1-Boc-3-cyanoazetidine (142253-54-1)

(2 customer reviews)

This product(s) resides on a APICMO contract.

The ability to produce, synthesize and manufacture large quantities of 1-Boc-3-cyanoazetidine (142253-54-1) with quality control system under CGMP manufacturing
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SKU: 142253-54-1 Category:

Description

1-Boc-3-cyanoazetidine (142253-54-1) video

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1-Boc-3-cyanoazetidine (142253-54-1) Specifications

CAS 142253-54-1
CAS Min % 95.0
CAS Max % 100.0
MDL Number MFCD06796640
InChI Key WEFREESWPHICPL-UHFFFAOYSA-N
Chemical Name or Material 1-Boc-3-cyanoazetidine; 142253-54-1; Tert-butyl 3-cyanoazetidine-1-carboxylate; 1-n-boc-3-cyano-azetidine; 1-(n-boc)-3-cyanoazetidine; 1-N-Boc-3-cyanoazetidine
Infrared Spectrum Authentic
Physical Form Cream
Packaging Sealed foil bag
Molecular Formula C9H14N2O2
Molecular Weight (g/mol) 182.223 g/mol
SMILES CC(C)(C)OC(=O)N1CC(C1)C#N
Color No data available
Melting Point 68-71°C
Assay 98%

1-Boc-3-cyanoazetidine (142253-54-1) Safety and HandlingAPICMO hazard icons

(142253-54-1) Hazard description:

  • Harmful if swallowed [Warning Acute toxicity, oral]
  • Causes skin irritation [Warning Skin corrosion/irritation]
  • Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
  • Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

1-Boc-3-cyanoazetidine Precautionary statement:

  • Avoid breathing dust/fume/gas/mist/vapors/spray.
  • Wear protective gloves/protective clothing/eye protection/face protection.
  • IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
  • Store locked up.
  • Dispose of contents/container in accordance with local/regional/national/international regulations.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

1-Boc-3-cyanoazetidine (142253-54-1) Articles

Not data available

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

1-Boc-3-cyanoazetidine (142253-54-1) Bulk Ordering & Pricing:

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2 reviews for 1-Boc-3-cyanoazetidine (142253-54-1)

  1. APICMO

    At Apicmo.com, we synthesis, process and manufacture best qualities of 1432253-54-1(1-Boc-3-cyanoazetidine) in strict adherence to manufacturing regulations stipulated under the quality control system of CGMP. Our production is exclusively done through skilful application of modern technology. We are effective in producing all (small and large) quantities of 1-Boc-3-cyanoazetidine, (1432253-54-1).

    Chemical Structure Of 1-Boc-3-Cyanoazetidine (142253-54-1)

    1-Boc-3-cyanoazetidine powder (142253-54-1) -APICMO Azetidines

     1-Boc-3-cyanoazetidine Applications

    CAS No.: 1432253-54-1 indentifies 1-Boc-3-cyanoazetidine. It is commonly identified by the chemical name 1-Boc-3-cyanoazetidine, and its molecular formula is C9H14N2O2.

    1-Boc-3-cyanoazetidine is used as reactant/ reagent for preparation of substituted pyridines through nucleophilic aromatic substitution of cyanopyridines with disubstituted esters and nitriles.   1432253-54-1 is also a vital reagent/reactant in preparation and SAR (Specific absorption rate) of pyridinylmethanol derivatives as TRPV3 antagonists.

    1-Boc-3-cyanoazetidine (1432253-54-1) Synonyms

    The other names for 1-Boc-3-cyanoazetidine are:

    • 1-(N-Boc)-3-cyanoazetidine;
    • tert-butyl 3-cyanoazetidine-1-carboxylate

    1-Boc-3-cyanoazetidine (1432253-54-1) computed properties

    Property Name Property Value
    Covalently-Bonded Unit Count 1
    Isotope Atom Count 0
    Defined Atom Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Heavy Atom Count 13
    Formal Charge 0
    Compound Is Canonicalized True
    XLogP3 0.6
    Monoisotopic Mass 182.106 g/mol
    Exact Mass 186.106 g/mol
    Topological Polar Surface Area 53.3 A^2
    CACTVS Substructure Key Fingerprint AAADccBzMAAAAAAAAAAAAAAAAABYAAA
    AAAAAAAAAAAAAAAAAAAAAHgAAAAAAD
    UTBgAQCCAMABAAYBAAAGAAAAAAAAAA
    AAAAIAAAAgAAAAAAMAAAABgAAAAAAAAA
    AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA==
    Complexity 253
    Rotatable Bond Count 2
    Hydrogen Bond Acceptor Count 3
    Hydrogen Bond Donor Count 0
    Molecular Weight 182.223 g/mol

     

    1-Boc-3-cyanoazetidine (1432253-54-1) safety procedures

    The precautionary measures outlined by apicmo.com should be strictly adhered to when dealing with 1-Boc-3-cyanoazetidine (1432253-54-1). Be vigilant to;

    § Avoid inhaling any gases, dust, fumes, mist, and vapour or sprays related to 1-Boc-3-cyanoazetidine by engaging protective nose masks.  1-Boc-3-cyanoazetidine should only be used outdoors or in a well-ventilated room.

    § Fully shield your skin, face and eyes always by wearing protective gears. Cover your face using facial masks, quality industrial gloves for your hands and special/contact lenses for your eyes to ensure maximum protection.

    1-Boc-3-cyanoazetidine (1432253-54-1) Hazards identification

    § 1-Boc-3-cyanoazetidine (1432253-54-1) is very harmful if swallowed. Seek medical attention immediately.

    § If it gets in the eye, 1-Boc-3-cyanoazetidine (1432253-54-1) causes critical eye irritation. Cautiously Rinse the eyes with plentiful amounts of water for several minutes. Eradicate easy to remove contact lenses if available, persist in rinsing for a few more minutes.

    § In case of skin contact, 1-Boc-3-cyanoazetidine has serious skin irritation /corrosion.

    § Inhalation of 1-Boc-3-cyanoazetidine (1432253-54-1) causes respiratory irritation. Fumes, gases, dust, sprays, vapours or mist of 1-Boc-3-cyanoazetidine (1432253-54-1) should be avoided fully. Contact a poison centre or physician instantly after you encounter acute respiratory symptoms.

    § 1-Boc-3-cyanoazetidine has toxic effects on aquatic life with lifelong effects.

    §  Do not release 1-Boc-3-cyanoazetidine to the environment.

     

    1-Boc-3-cyanoazetidine (1432253-54-1) Information of ingredients/Composition

    Raw Materials: Sodium hydroxide, Hydrochloric acid, Methanol, Tetrahydrofuran, Dichloromethane, Thionyl chloride, Toluene, Ammonia, Lithium aluminium hydride, Palladium, Acetonitrile, Formaldehyde, Di-tert-butyl dicarbonate, Diethyl malonate, Phosphorus pentoxide, Ethyldiisopropylamine

    Ingredient name: 1-Boc-3-cyanoazetidine.

    1-Boc-3-cyanoazetidine (142253-54-1)

    1-Boc-3-cyanoazetidine (1432253-54-1) Synthesis route

    1-Boc-3-cyanoazetidine (142253-54-1)

    6-Chloro-5-azaindole

     1-Boc-3-cyanoazetidine (142253-54-1)

     

    1-Boc-3-cyanoazetidine (1432253-54-1) First aid measures

    Eye contact: Remove goggles to expose skin. Immediately search for and remove contact lenses where applicable and wash eye skin continuously for about 15 or more minutes with copious amounts of water. Using your fingers, separate the eyelids gently to assure enough water flushes the eye.  Pursue medical attention in case of interminable irritation.

    Inhalation: Quickly remove to well a ventilated uncontaminated room or exposed fresh air. Administer oxygen if breathing in difficulty then seek medical attention.

    Ingestion: Do not prompt vomiting.  Rinse out mouth with and drink large amounts of water immediately. Seek medical attention.

    Skin contact: Immediately take off contaminated shoes and attire, and subsequently cleanse the skin for not less than 20 minutes with sufficient amounts of water. Seek medical care promptly if irritation carries on.

    Fire fighting measures

    In occurrence of a fire while dealing with 1-Boc-3-cyanoazetidine (1432253-54-1), exclusively or conjointly with other chemicals /materials, either alcohol, carbon dioxide polymer foam or dry chemical powder fire extinguishers can be used. 1-Boc-3-cyanoazetidine emits toxic gases under fire conditions. Thus, suitable safeguarding gear and self-contained breathing gadgetry should be put on.

    Accidental release measures for 1-Boc-3-cyanoazetidine (1432253-54-1)

    Personal precautions: invariably put on suitable personal protective equipment with satisfactory performance and is acceptable with state/ local/ national standards.

    Hand precaution: Selectively have fit gauntlets /gloves on.

    Respiratory precaution: You should at all times wear approved respirator/ mask whenever dealing with 1-Boc-3-cyanoazetidine (1432253-54-1).

    Eye protection: safeguard your eyes by having appropriate eye protection set on.

    Skin protection: Cautiously wear appropriate protective attire.

    Methods for cleaning up 1-Boc-3-cyanoazetidine (1432253-54-1)

    In case of spillage, intermix 1-Boc-3-cyanoazetidine (1432253-54-1) with a dormant absorbent materialand, clean off and lock in a firmly lidded container for disposal.

    Environmental precautions

    Under no circumstances should you allow 1-Boc-3-cyanoazetidine (1432253-54-1) into water courses or drains.

    1-Boc-3-cyanoazetidine (1432253-54-1) Storage and Handling

    Handling:

    Ø Be cautious when handling 1-Boc-3-cyanoazetidine.

    Ø Avoid prolonged exposure. Limit exposure to any chemical.

    Ø Avoid breathing vapor or dust.

    Ø Do not get on skin, in eyes or on clothing.

    Ø Have eye wash and safety shower available.

    Ø Keep container tightly sealed.

    Ø Ensure adequate ventilation during use.

    Ø Use only in a chemical fume hood.

    Ø To the best of our knowledge, the health hazards of this product have not been fully investigated.

    Handling of 1-Boc-3-cyanoazetidine (1432253-54-1) should only be by or under very strict supervision of personnel fully qualified and certified in the handling and use of probably toxic chemicals, with ability to consider the health, fire, and chemical hazard data as indicated in this particular content.

    Storage: carefully store in tightly sealed vessels, refrigerated.

    Personal protection / Exposure Controls

    Engineering Controls: Use 1-Boc-3-cyanoazetidine (1432253-54-1) while in a well ventilated room or enclosed in a chemical fume chamber.

    Personal protective equipment: Always put on safety protective goggles, protective clothing, chemical-resistant gloves, and chemical-resistant boots.

    General hygiene measures:  assure a thorough clean out after handling. Cleanse contaminated attire after and before reuse.

    Physical and chemical properties

    Appearance: White powder or crystalline powder

    Boiling point: 290.154ºC at 760 mmHg

    Melting point: 68-71°C

    Storage: Keep refrigerated

    Molecular formula: C9H14N2O2

    Molecular weight: 182.22

    1-Boc-3-cyanoazetidine Stability and reactivity

    Conditions to avoid: Avoid indirect or direct flames, sparks and heat.

    Materials to avoid: Avoid contact with strong oxidizing agents, strong acids and bases.

    Probable hazardous decomposition products: Nitrogen oxides, Carbon monoxide, and carbon dioxide.

    Toxicological information

    Acute toxicity: 1-Boc-3-cyanoazetidine is harmful when swallowed.

    Skin corrosion/ irritation: 1-Boc-3-cyanoazetidine causes skin irritation.

    Eye damage/irritation: causes serious eye irritation with probable eye damage in adverse.

    Respiratory or skin sensitization: irritant to upper respiratory tract and mucous membranes.

    Carcinogenicity: EPA, IARC, NTP, OSHA or ACGIH has no classification data on carcinogenic properties 1-Boc-3-cyanoazetidine.

    Reproductive toxicity: No effects known.

    Specific target organ system toxicity – repeated exposure: No effects known.

    1-Boc-3-cyanoazetidine Ecological information

    Toxicity: Has long lasting effects toxic to aquatic life.

    Additional information

    The toxicological, chemical and physical properties of 1-Boc-3-cyanoazetidine have not been investigated in depth.

    Other adverse effects:  There is no further relevant information available.

    Disposal consideration

    In accordance with national and regional regulation, 1-Boc-3-cyanoazetidine should be disposed by a licensed disposal company as special waste, in appropriate collaboration with local/ state waste disposal authority.

    1-Boc-3-cyanoazetidine (1432253-54-1) Transportation information

    It’s non-hazardous to transport 1-Boc-3-cyanoazetidine  on air or ground. Shipping 1432253-54-1 is classed non-hazardous.

    Regulatory Information

    No chemicals in 1-Boc-3-cyanoazetidine that require reporting as per SARA Title III, Section 302, or have CAS numbers that are beyond the threshold reporting levels stipulated by SARA Title III, Section 313.

    Adhere to all local, federal or state laws.

    Other Information

    All the information herein is to the best of our knowledge considered accurate, but not the complete information and is just given as a guide. The end user is exclusively responsible for resultant injuries or damages from handling or contacting this product.

    Technical Service

    At Apicmo, we conduct thorough research in diverse areas including chemical synthesis, life science, material science and chromatography among others through our skilled and experienced team of scientists.

    1-Boc-3-cyanoazetidine (1432253-54-1) Bulk Ordering and Pricing

    Do you require large quantities of 1-Boc-3-cyanoazetidine for research, development or industrial manufacturing? Place your order now by contacting our very welcoming and friendly customer service team.

    BIBLIOGRAPHY

    1. National Centre For Biotechnology Information, US. National Library Of Medicine, Pubchem 1-Boc-3-cyanoazetidine (1432253-54-1)Sections 1-9.
    2. Alfred Hassner, John Wiley & Sons,Small Ring Heterocycles, 15 Sep 2009, Part 2, Page 12-15.
    3. Robert E. Gawley, John Wiley & Sons, 16 Apr 2010,Stereochemical Aspects of Organolithium Compounds , page 24-26.
  2. Apicmo

    The best 1-Boc-3-cyanoazetidine and service i have ever had,Nice experience

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