Quinazoline is an organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water. Also known as 1,3-diazanaphthalene, quinazoline received its name from being an aza derivative of quinoline. Though the parent quinazoline molecule is rarely mentioned by itself in technical literature, substituted derivatives have been synthesized for medicinal purposes such as antimalarial and anticancer agents,
Aapproved afatinib, a drug developed by Boehringer Ingelheim.
Erlotinib, a drug manufactured by Astellas, to treat NSCLC patients with tumors caused by mutations of EGFR.
GlaxoSmithKline’s drug lapatinib was treat advanced-stage or metastatic breast cancer in combination with Roche’s capecitabine.
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2-Chloro-4-Amino-6,7-Dimethoxyquinazoline (23680-84-4)
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2,4-Dichloro-6,7-dimethoxy-quinazoline (27631-29-4)
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4-Chloroquinazoline (5190-68-1)
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6-BroMo-4-chloroquinazoline.HCl salt (38267-96-8)
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6-Bromoquinazolin-2(1H)-one (162012-72-8)
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6-Bromoquinazolin-2(1H)-one (79885-37-3)
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7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)
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7-Bromo-6-chloro-3H-quinazolin-4-one (17518-98-8)
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