2-Chloro-5-methylpyrimidine : CAS (Chemical Abstracts Services) Registry Number 22536-61-4
Physical and Chemical Properties of 2-Chloro-5-methylpyrimidine
2- Chloro-5 methylpyrimidine has a light yellow crystalline powder appearance at room temperature . Some would describe the color shade as off-white. It has no odor and a molecular weight of 128.56 grams per mole. Its chemical formula is noted as C5H5CIN2 and the Simplified Molecular – Input line Entry System (SMILES) as CC1=CN=C(CL)N=C1. The compound has a melting point that ranges between 89-92 degrees centigrade,and a boiling point of 239 .2 degrees at 750mm/hg. The solid is slightly soluble in water. It is typically manufactured and sold as a pharmaceutical intermediate with an average assay (purity) between 97% and 98%, the lowest noted as 95%. The density of a single mole of 2-Chloro-5-methylpyrimidine (22536-61-4) is approximately 1.169 grams per mole at 25 degrees centigrade. Enthalpy of vaporization is 45.68 KJ/mol and the vapour pressure is measured at approximately 0.0626 mmHg at 25 degrees Celsius. Common synonyms used for for 2-chloro-5-methylprimidine are: Pyrimidine, 2-Chloro-5-methylpyrimidine, 2- chloro-5-methyl-(8Cl,9Cl) and 5- methyl-2- chloropyrimidine.
Preparation of 2-Chloro-5-methylpyrimidine (22536-61-4)
2- chloro-5 methylpyrimidine can be synthesized using a number of methods. Common practice for the preparation has been to obtain it as 25% of the product that results from the reaction between phosphorus oxychloride and 3- methylpyridine 1- oxide. However, to obtain an even higher yield, 2-Chloro-5-methylpyrimidine (22536-61-4) can be prepared by reacting phosphorus oxychloride with 3- methylpyridine 1 – Oxide. The improvement involves carrying out the reaction with a basic organic nitrogen compound present and a diluent (preferably an inert organic solvent)all performed in a temperature range between -50 degrees and +50 degrees Celsius. Yields of even up to 70% can be obtained using different methods. Theoretical yields of over 96% have also been documented, though these have disadvantages proven a little difficult to bypass, making execution, especially on a large scale near impossible. Choice of preparation method selected may be affected by amount that one wants to produce and ease of separation from other by products. Nonetheless, depending on your ultimate use of the product, you can always find out the process used in preparation, or select the appropriate method you would like to use should you be carrying out the preparation yourself.
What exactly is a Pyramidine?
Simply put, they are aromatic compounds with Carbon and Nitrogen atoms in a six membered ring. The ring is fairly stable. Pyramidine derivatives, have for a long time now played a crucial role in the development of drugs either on their own or in conjuction with other compounds. They have been used, and continue to be used in a wide range of pharmaceuticals including, but not limited to , drugs for the treatment of high blood pressure, anti epilepsy medication, general anaesthetics , anti malarial drugs and even in the synthesis of HIV Medication. Our focus in this article is on 2-chloro-5 methylpyramidine and its uses as an intermediate
Uses and applications of 2- Chloro-5- methylpyramidine
It is typically used in organic synthesis; commonly used as a pesticide intermediate such as acetamiprid, imidacloprid , as a herbicide as well as bactericide. It is also used as a pharmaceutical intermediate, catalytic agent and petrochemical additive. 2- Chloro-5- methylpyramidine been used in the making of new neonicotinoid compounds that have insecticidal activity. Other uses in Agro product synthesis include the making of: Imidacloprid, Acetamiprid, Nitenpyram, NTN32693. These have proven efficiency in both residential and industrial farms to destroy insects hazardous to fruit, vegetable or cereal crops.
Other chemical compounds that 2-Chloro-5 methylpyramidine can be used to make include:
1- (5′-methyl-2, 2′-bipyridin-5-yl-2,5-dimethyl-1H-pyrrole
Storage and Transportation
2-Chloro-5 methylpyramidine is known to be chemically stable when stored under recommended conditions: At room temperature. Do not attempt to use aluminium or galvanized containers, as the compound will react with these to produce hydrogen gas which can ultimately form an explosive mixture with air. Make sure you check containers regularly to detect and tend to any spills or leaks early.
Due to its stability and non hazardous nature, 2- chloro-5- methylpyramidine can be transported by either air or sea. It is highly reactive with hydrogen oxides, carbon oxides, and nitrogen oxides, thus it is advised to select transport or storage options with no exposure to any of these compounds. Containers should be kept tightly closed, in a cool dry and well ventilated place
Proper Handling, Safety Precautions, Disposal and Fire Fighting Measures
Always wear protective gear such as chemical resistant gloves and safety goggles when dealing with 2-Chloro-5-methylpyrimidine (22536-61-4) to avoid any contact with the eyes or skin. Avoid inhaling the mist, vapor or gas : Always use it in a well ventilated space. Continuous inhalation has been proven to have adverse health effects. As always, strive to practice good industrial hygiene and safety.
Nonetheless, In case of accidental swallowing: Rinse mouth with water and consult a physician. In the case of inhalation: Move the affected person(s) to fresh air and if they are not breathing, proceed to administer artificial respiration, and consult a medical practitioner. For accidental skin contact, wash the affected area thoroughly with soap and water for a minimum of fifteen minutes and remove any contaminated clothing or shoes. 2- chloro-5- methylpyrimidine can burn the skin or cause sensitivity. Proceed to contact a medical practitioner.
2- chloro-5- methyl pyrimidine should be disposed off as special waste. This implies that special arrangements need to be put in place, using a licensed disposal company in liaison with your local waste disposal authority to ensure compliance with both national and regional legislation. The compound should not be released into drains, and in case of a sand spill, vermiculite into a sealed container and dispose appropriately.
To extinguish fires as a result of 2-Chloro-5-methylpyrimidine (22536-61-4) combustion one can use dry chemical fire extinguishers, Carbon (IV) oxide, polymer foam or alcohol resistant extinguishers. If necessary, one should wear protective fire fighting equipment and breathing apparatus to reduce the risk of burns.
In terms of occupational exposure limit values, 2- chloro-5- methylpyramid has no such limitations put in place. General precaution such as chemical fume hoods for engineers are recommended during handling.